ENSG00000106344

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223073 ENSG00000106344 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM28 protein_coding protein_coding 34.06422 25.58069 41.73994 0.2100605 0.05596645 0.7061553 3.196984 3.1509092 3.103798 0.1560582 0.03423404 -0.02166413 0.10208750 0.1231000 0.07433333 -0.04876667 2.907069e-04 1.004194e-05 FALSE TRUE
ENST00000415472 ENSG00000106344 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM28 protein_coding protein_coding 34.06422 25.58069 41.73994 0.2100605 0.05596645 0.7061553 4.128195 5.0129165 3.648507 0.3073402 0.37314783 -0.45727009 0.13540417 0.1958333 0.08743333 -0.10840000 1.004194e-05 1.004194e-05 FALSE TRUE
ENST00000481788 ENSG00000106344 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM28 protein_coding processed_transcript 34.06422 25.58069 41.73994 0.2100605 0.05596645 0.7061553 3.537608 4.5788662 2.886089 0.6829947 0.16289503 -0.66403168 0.11162917 0.1790000 0.06913333 -0.10986667 1.915443e-04 1.004194e-05 FALSE TRUE
ENST00000488249 ENSG00000106344 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM28 protein_coding retained_intron 34.06422 25.58069 41.73994 0.2100605 0.05596645 0.7061553 2.224452 0.9968607 2.439087 0.1668944 0.13004979 1.28237964 0.06590417 0.0391000 0.05843333 0.01933333 2.267841e-01 1.004194e-05   FALSE
MSTRG.30626.6 ENSG00000106344 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM28 protein_coding   34.06422 25.58069 41.73994 0.2100605 0.05596645 0.7061553 8.586197 3.3093560 13.577944 0.9709807 1.37156746 2.03335186 0.23071667 0.1291333 0.32523333 0.19610000 1.307272e-02 1.004194e-05 FALSE TRUE
MSTRG.30626.9 ENSG00000106344 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM28 protein_coding   34.06422 25.58069 41.73994 0.2100605 0.05596645 0.7061553 7.759240 5.4390869 10.273658 0.2470050 0.77119962 0.91626715 0.22219167 0.2126667 0.24616667 0.03350000 5.788598e-01 1.004194e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106344 E001 0.6277178 0.0231607878 4.507429e-01 5.917921e-01 7 128265002 128265038 37 - 0.263 0.140 -1.128
ENSG00000106344 E002 1.1341212 0.0168103023 1.448035e-01 2.545593e-01 7 128265533 128265588 56 - 0.192 0.463 1.777
ENSG00000106344 E003 1.3953985 0.0121072482 3.633993e-02 8.422735e-02 7 128266021 128266211 191 - 0.508 0.140 -2.541
ENSG00000106344 E004 8.0296397 0.0023102378 3.665249e-01 5.108670e-01 7 128280967 128281152 186 - 0.995 0.916 -0.296
ENSG00000106344 E005 4.0376311 0.0067132221 1.557272e-01 2.694005e-01 7 128281698 128281873 176 - 0.577 0.802 0.944
ENSG00000106344 E006 1.6712696 0.0147644022 3.098050e-01 4.521419e-01 7 128283971 128284014 44 - 0.325 0.517 1.041
ENSG00000106344 E007 101.5527474 0.0003424539 6.474648e-04 2.707015e-03 7 128297685 128303609 5925 - 1.939 2.084 0.489
ENSG00000106344 E008 11.5073161 0.0304618508 3.502359e-02 8.169657e-02 7 128303610 128303664 55 - 0.943 1.242 1.080
ENSG00000106344 E009 601.4724184 0.0055526112 4.852985e-20 3.095567e-18 7 128303665 128306998 3334 - 2.574 2.935 1.202
ENSG00000106344 E010 109.7440417 0.0002837698 2.629837e-04 1.228825e-03 7 128306999 128307453 455 - 1.971 2.120 0.499
ENSG00000106344 E011 334.2235867 0.0068365295 3.360781e-01 4.799050e-01 7 128307454 128310396 2943 - 2.533 2.516 -0.057
ENSG00000106344 E012 19.0144057 0.0011214654 5.817324e-01 7.062317e-01 7 128310397 128310412 16 - 1.267 1.334 0.235
ENSG00000106344 E013 38.6381194 0.0005460567 2.400219e-04 1.133442e-03 7 128310413 128310479 67 - 1.475 1.707 0.790
ENSG00000106344 E014 254.4276994 0.0004155710 4.654811e-12 1.022660e-10 7 128310480 128310779 300 - 2.311 2.499 0.629
ENSG00000106344 E015 262.7380277 0.0006682006 5.985082e-03 1.856984e-02 7 128310780 128310931 152 - 2.376 2.469 0.309
ENSG00000106344 E016 0.4720498 0.2018431438 7.781069e-01 8.572262e-01 7 128313088 128313174 87 - 0.192 0.141 -0.536
ENSG00000106344 E017 216.4317821 0.0002026708 1.550543e-01 2.684816e-01 7 128313175 128313274 100 - 2.309 2.369 0.200
ENSG00000106344 E018 317.2749932 0.0002185875 4.866798e-01 6.243991e-01 7 128314764 128315020 257 - 2.484 2.523 0.131
ENSG00000106344 E019 134.9039825 0.0002303895 1.081557e-01 2.028109e-01 7 128317659 128317733 75 - 2.144 2.120 -0.081
ENSG00000106344 E020 195.7486985 0.0012934567 6.508713e-01 7.618513e-01 7 128317957 128318101 145 - 2.288 2.299 0.034
ENSG00000106344 E021 77.8129070 0.0032846524 7.900624e-01 8.657136e-01 7 128318102 128318106 5 - 1.892 1.902 0.036
ENSG00000106344 E022 220.6983451 0.0003622755 4.970740e-01 6.336239e-01 7 128321266 128321424 159 - 2.342 2.350 0.027
ENSG00000106344 E023 0.8104664 0.0157497281 4.679054e-01 6.073425e-01 7 128321425 128321425 1 - 0.192 0.331 1.041
ENSG00000106344 E024 131.4320518 0.0002359699 8.590113e-01 9.130377e-01 7 128323527 128323558 32 - 2.114 2.133 0.066
ENSG00000106344 E025 140.6407762 0.0002175813 9.808381e-02 1.876028e-01 7 128323559 128323591 33 - 2.163 2.138 -0.082
ENSG00000106344 E026 228.8003179 0.0006850439 1.866867e-01 3.095763e-01 7 128324559 128324694 136 - 2.368 2.359 -0.028
ENSG00000106344 E027 147.0750531 0.0019264464 1.383404e-01 2.457986e-01 7 128325818 128325891 74 - 2.186 2.160 -0.086
ENSG00000106344 E028 182.1890212 0.0002378884 5.937089e-01 7.160571e-01 7 128330819 128330928 110 - 2.260 2.272 0.038
ENSG00000106344 E029 181.2771737 0.0002049452 1.594136e-02 4.260122e-02 7 128333290 128333362 73 - 2.278 2.239 -0.130
ENSG00000106344 E030 118.6066558 0.0002818317 8.762915e-03 2.569111e-02 7 128335543 128335544 2 - 2.103 2.042 -0.206
ENSG00000106344 E031 117.2695484 0.0002702828 1.135989e-02 3.202717e-02 7 128335545 128335546 2 - 2.097 2.039 -0.197
ENSG00000106344 E032 262.5274869 0.0012415137 1.641675e-02 4.364996e-02 7 128335547 128335679 133 - 2.438 2.397 -0.139
ENSG00000106344 E033 14.5896225 0.0012272940 1.631671e-01 2.792860e-01 7 128335680 128335846 167 - 1.233 1.133 -0.356
ENSG00000106344 E034 298.9169060 0.0014397095 2.640699e-05 1.591856e-04 7 128335847 128336042 196 - 2.515 2.425 -0.301
ENSG00000106344 E035 143.4192363 0.0025714416 1.104255e-04 5.699279e-04 7 128337131 128337202 72 - 2.212 2.086 -0.421
ENSG00000106344 E036 2.1423770 0.0084349530 3.545389e-01 4.988549e-01 7 128337203 128337204 2 - 0.544 0.403 -0.711
ENSG00000106344 E037 99.8124160 0.0018980338 6.366975e-05 3.494016e-04 7 128338250 128338279 30 - 2.062 1.921 -0.474
ENSG00000106344 E038 137.5892607 0.0006020226 1.254523e-06 1.020374e-05 7 128338280 128338342 63 - 2.198 2.066 -0.440
ENSG00000106344 E039 127.6320776 0.0002261680 1.015986e-06 8.414232e-06 7 128338726 128338801 76 - 2.166 2.035 -0.437
ENSG00000106344 E040 152.0533889 0.0005881827 9.827699e-06 6.545821e-05 7 128339227 128339321 95 - 2.233 2.122 -0.371
ENSG00000106344 E041 212.2197388 0.0002058356 7.836043e-13 1.957946e-11 7 128339633 128339791 159 - 2.393 2.239 -0.516
ENSG00000106344 E042 4.7179592 0.0038949605 2.721460e-04 1.266421e-03 7 128341118 128341219 102 - 0.929 0.402 -2.298
ENSG00000106344 E043 158.3746716 0.0015604286 1.880848e-09 2.647944e-08 7 128343676 128343908 233 - 2.277 2.096 -0.607