ENSG00000106330

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223054 ENSG00000106330 HEK293_OSMI2_2hA HEK293_TMG_2hB MOSPD3 protein_coding protein_coding 13.32956 24.04514 7.73055 0.9504845 0.2973993 -1.635837 1.6892008 2.391909 1.8881208 0.2201684 0.4388099 -0.3396099 0.15452083 0.10053333 0.2457667 0.14523333 5.120197e-02 1.142142e-06 FALSE TRUE
ENST00000393950 ENSG00000106330 HEK293_OSMI2_2hA HEK293_TMG_2hB MOSPD3 protein_coding protein_coding 13.32956 24.04514 7.73055 0.9504845 0.2973993 -1.635837 9.2697398 17.666844 4.5409312 0.8303966 0.4183236 -1.9576271 0.66381667 0.73486667 0.5858333 -0.14903333 3.418569e-02 1.142142e-06 FALSE TRUE
ENST00000462372 ENSG00000106330 HEK293_OSMI2_2hA HEK293_TMG_2hB MOSPD3 protein_coding nonsense_mediated_decay 13.32956 24.04514 7.73055 0.9504845 0.2973993 -1.635837 0.5420878 1.259808 0.0000000 0.3517305 0.0000000 -6.9884671 0.02935417 0.05183333 0.0000000 -0.05183333 1.142142e-06 1.142142e-06   FALSE
ENST00000497456 ENSG00000106330 HEK293_OSMI2_2hA HEK293_TMG_2hB MOSPD3 protein_coding retained_intron 13.32956 24.04514 7.73055 0.9504845 0.2973993 -1.635837 0.9240413 1.127177 0.8350914 0.4840803 0.1966035 -0.4282770 0.07722917 0.04666667 0.1076667 0.06100000 3.467345e-01 1.142142e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106330 E001 0.9565815 0.0791235858 0.2109465248 0.339655495 7 100612102 100612157 56 + 0.001 0.303 9.697
ENSG00000106330 E002 4.9465322 0.0038071892 0.1377496067 0.244943211 7 100612158 100612181 24 + 0.858 0.644 -0.868
ENSG00000106330 E003 7.9065327 0.0231367768 0.0826648992 0.163721508 7 100612182 100612183 2 + 1.039 0.807 -0.878
ENSG00000106330 E004 16.5963103 0.0018988278 0.0135346413 0.037160290 7 100612184 100612241 58 + 1.320 1.094 -0.802
ENSG00000106330 E005 0.0000000       7 100612372 100612429 58 +      
ENSG00000106330 E006 0.8062992 0.0535024400 0.3695636082 0.513963012 7 100612430 100612485 56 + 0.000 0.227 11.036
ENSG00000106330 E007 0.3697384 0.0274424043 1.0000000000 1.000000000 7 100612540 100612540 1 + 0.000 0.127 10.247
ENSG00000106330 E008 6.0754118 0.0028591272 0.3176050137 0.460500033 7 100612541 100612555 15 + 0.614 0.774 0.670
ENSG00000106330 E009 43.8047452 0.0009266402 0.3880309086 0.532146803 7 100612556 100612602 47 + 1.489 1.548 0.201
ENSG00000106330 E010 86.9182716 0.0004205394 0.1608305897 0.276204544 7 100612603 100612729 127 + 1.774 1.841 0.227
ENSG00000106330 E011 111.2345877 0.0002908335 0.9775481396 0.990037168 7 100612730 100612814 85 + 1.938 1.938 0.000
ENSG00000106330 E012 55.2688120 0.0005593416 0.4761304448 0.614811704 7 100612815 100612824 10 + 1.604 1.646 0.145
ENSG00000106330 E013 80.3012465 0.0011244630 0.6238903850 0.740365451 7 100612825 100612915 91 + 1.774 1.799 0.086
ENSG00000106330 E014 88.3184872 0.0004136156 0.3254294695 0.468872961 7 100612916 100612996 81 + 1.871 1.828 -0.145
ENSG00000106330 E015 2.8515656 0.0055195406 0.0000490814 0.000277107 7 100612997 100613193 197 + 0.927 0.306 -2.867
ENSG00000106330 E016 99.3386274 0.0003776117 0.7333084454 0.824542566 7 100613194 100613269 76 + 1.899 1.886 -0.046
ENSG00000106330 E017 95.6175250 0.0002950652 0.6571547070 0.766577308 7 100613477 100613506 30 + 1.889 1.871 -0.061
ENSG00000106330 E018 224.2059361 0.0002087220 0.8017271909 0.873664415 7 100613507 100613706 200 + 2.234 2.242 0.026
ENSG00000106330 E019 3.8267079 0.0087862979 0.0297749051 0.071520704 7 100613707 100613789 83 + 0.858 0.529 -1.385
ENSG00000106330 E020 156.7819884 0.0017132930 0.2646300216 0.402596777 7 100614867 100615031 165 + 2.053 2.096 0.146
ENSG00000106330 E021 0.4772466 0.0220333537 0.6184503458 0.736069158 7 100615032 100615032 1 + 0.210 0.127 -0.868
ENSG00000106330 E022 55.5330376 0.0468324339 0.9396666321 0.966097688 7 100615152 100615384 233 + 1.656 1.644 -0.039