ENSG00000106263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360876 ENSG00000106263 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3B protein_coding protein_coding 248.8812 335.0827 224.0836 21.10509 5.651949 -0.5804591 70.191909 70.28601 77.54722 14.2181484 3.0504062 0.1418184 0.27772500 0.21136667 0.34666667 0.1353000000 1.302341e-01 8.521915e-37 FALSE TRUE
ENST00000431643 ENSG00000106263 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3B protein_coding protein_coding 248.8812 335.0827 224.0836 21.10509 5.651949 -0.5804591 2.506351 0.00000 11.51345 0.0000000 2.1840854 10.1703571 0.01155000 0.00000000 0.05113333 0.0511333333 8.521915e-37 8.521915e-37 FALSE FALSE
MSTRG.29398.12 ENSG00000106263 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3B protein_coding   248.8812 335.0827 224.0836 21.10509 5.651949 -0.5804591 29.164524 71.69866 15.65568 14.6281510 3.5946053 -2.1945405 0.11205417 0.21220000 0.06926667 -0.1429333333 1.363959e-03 8.521915e-37 FALSE TRUE
MSTRG.29398.4 ENSG00000106263 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3B protein_coding   248.8812 335.0827 224.0836 21.10509 5.651949 -0.5804591 80.767227 126.01054 51.36419 9.9772241 1.1077049 -1.2945432 0.31828333 0.37523333 0.22956667 -0.1456666667 1.475028e-13 8.521915e-37 FALSE TRUE
MSTRG.29398.5 ENSG00000106263 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3B protein_coding   248.8812 335.0827 224.0836 21.10509 5.651949 -0.5804591 13.347258 18.39884 12.26665 0.7978318 0.4467439 -0.5844822 0.05403333 0.05513333 0.05480000 -0.0003333333 1.000000e+00 8.521915e-37 FALSE TRUE
MSTRG.29398.6 ENSG00000106263 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3B protein_coding   248.8812 335.0827 224.0836 21.10509 5.651949 -0.5804591 18.997748 28.11267 12.29017 1.5942760 0.3393735 -1.1930547 0.07640000 0.08420000 0.05483333 -0.0293666667 8.406518e-05 8.521915e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106263 E001 0.000000       7 2353944 2353946 3 +      
ENSG00000106263 E002 0.000000       7 2353947 2354085 139 +      
ENSG00000106263 E003 4.758577 0.0034593355 4.265035e-03 1.388473e-02 7 2354086 2354195 110 + 0.969 0.574 -1.596
ENSG00000106263 E004 7.737238 0.0021434584 2.304636e-01 3.630068e-01 7 2354524 2354717 194 + 1.010 0.857 -0.578
ENSG00000106263 E005 7.379141 0.0022626221 8.434456e-02 1.663714e-01 7 2354718 2354770 53 + 1.029 0.813 -0.818
ENSG00000106263 E006 5.956377 0.0033334592 9.226758e-05 4.856179e-04 7 2354771 2354826 56 + 1.099 0.600 -1.954
ENSG00000106263 E007 43.165591 0.0587415073 5.095304e-10 7.962469e-09 7 2354827 2354866 40 + 2.007 1.167 -2.879
ENSG00000106263 E008 63.270004 0.0620353269 1.502407e-09 2.155282e-08 7 2354867 2354874 8 + 2.164 1.348 -2.767
ENSG00000106263 E009 90.684023 0.0977717911 8.666299e-07 7.295287e-06 7 2354875 2354881 7 + 2.310 1.526 -2.641
ENSG00000106263 E010 325.386874 0.0496788471 2.513951e-11 4.906866e-10 7 2354882 2355116 235 + 2.857 2.090 -2.558
ENSG00000106263 E011 379.657496 0.0293282927 6.636467e-07 5.727047e-06 7 2355117 2355233 117 + 2.803 2.355 -1.492
ENSG00000106263 E012 1246.515156 0.0064142515 7.044818e-11 1.275317e-09 7 2355234 2355420 187 + 3.235 2.951 -0.944
ENSG00000106263 E013 1971.103073 0.0028760290 2.490096e-09 3.430596e-08 7 2360710 2360902 193 + 3.375 3.192 -0.608
ENSG00000106263 E014 1977.366064 0.0031313487 5.396253e-06 3.812433e-05 7 2362645 2362764 120 + 3.355 3.206 -0.497
ENSG00000106263 E015 1.361909 0.0098532393 5.859807e-01 7.096248e-01 7 2363021 2363069 49 + 0.284 0.376 0.573
ENSG00000106263 E016 1799.829674 0.0016414847 1.294955e-09 1.880175e-08 7 2363070 2363127 58 + 3.315 3.165 -0.500
ENSG00000106263 E017 2606.975510 0.0010290732 4.021853e-10 6.412455e-09 7 2363632 2363760 129 + 3.461 3.335 -0.419
ENSG00000106263 E018 1429.821456 0.0004308168 2.588794e-07 2.426716e-06 7 2364372 2364396 25 + 3.178 3.088 -0.299
ENSG00000106263 E019 2822.321748 0.0002332669 6.055786e-09 7.787473e-08 7 2364397 2364529 133 + 3.464 3.388 -0.253
ENSG00000106263 E020 2796.454328 0.0004959093 6.190933e-03 1.911711e-02 7 2366317 2366448 132 + 3.444 3.390 -0.181
ENSG00000106263 E021 42.913904 0.0096253763 2.322405e-08 2.673793e-07 7 2366449 2366524 76 + 1.850 1.432 -1.421
ENSG00000106263 E022 1246.477450 0.0017291720 1.747842e-01 2.944261e-01 7 2366525 2366529 5 + 3.092 3.040 -0.172
ENSG00000106263 E023 1838.032848 0.0008764346 1.308769e-01 2.353735e-01 7 2366530 2366591 62 + 3.256 3.210 -0.152
ENSG00000106263 E024 33.057239 0.0006454827 6.389133e-19 3.601315e-17 7 2366592 2366743 152 + 1.802 1.249 -1.898
ENSG00000106263 E025 21.995574 0.0008974551 1.332647e-13 3.720942e-12 7 2366934 2366998 65 + 1.634 1.079 -1.933
ENSG00000106263 E026 1519.380032 0.0008595464 2.833100e-02 6.866441e-02 7 2366999 2367045 47 + 3.182 3.124 -0.192
ENSG00000106263 E027 4.179235 0.0048620062 1.426143e-03 5.393754e-03 7 2367046 2367119 74 + 0.947 0.486 -1.928
ENSG00000106263 E028 3151.904799 0.0007190437 5.166615e-02 1.121217e-01 7 2369472 2369682 211 + 3.453 3.460 0.021
ENSG00000106263 E029 1974.018430 0.0005309418 2.386149e-08 2.739856e-07 7 2371777 2371849 73 + 3.213 3.272 0.195
ENSG00000106263 E030 23.666153 0.0011029293 1.322451e-29 2.141320e-27 7 2371850 2372190 341 + 1.759 0.909 -2.987
ENSG00000106263 E031 2518.669897 0.0002271329 1.082802e-09 1.595625e-08 7 2372673 2372795 123 + 3.330 3.375 0.150
ENSG00000106263 E032 14.733760 0.0066902880 5.267040e-06 3.729350e-05 7 2373118 2374527 1410 + 1.414 0.968 -1.591
ENSG00000106263 E033 2169.520125 0.0005297707 4.992177e-02 1.090348e-01 7 2374528 2374606 79 + 3.291 3.299 0.025
ENSG00000106263 E034 15.509602 0.0014123644 6.719501e-03 2.049275e-02 7 2374607 2375388 782 + 1.338 1.088 -0.888
ENSG00000106263 E035 3149.787954 0.0010972436 1.569127e-01 2.709836e-01 7 2375389 2375527 139 + 3.455 3.459 0.014
ENSG00000106263 E036 75.101141 0.0175359108 2.927441e-09 3.981013e-08 7 2375975 2376949 975 + 2.120 1.641 -1.613
ENSG00000106263 E037 2753.916294 0.0017749604 1.396278e-01 2.475141e-01 7 2376950 2377075 126 + 3.391 3.402 0.039
ENSG00000106263 E038 6.690717 0.0498328375 1.363819e-01 2.430087e-01 7 2377824 2378686 863 + 1.010 0.776 -0.896
ENSG00000106263 E039 4.617276 0.0635865966 4.532546e-01 5.939995e-01 7 2378687 2378688 2 + 0.627 0.771 0.598
ENSG00000106263 E040 1958.152565 0.0015777342 1.914315e-03 6.960201e-03 7 2378689 2378766 78 + 3.218 3.265 0.155
ENSG00000106263 E041 28.209797 0.0007220921 2.029228e-04 9.763804e-04 7 2378767 2379133 367 + 1.595 1.335 -0.894
ENSG00000106263 E042 2633.541679 0.0013470269 1.277438e-07 1.271378e-06 7 2379134 2379242 109 + 3.320 3.402 0.272
ENSG00000106263 E043 3067.530135 0.0013544717 2.534577e-14 7.852297e-13 7 2379394 2379511 118 + 3.354 3.479 0.415
ENSG00000106263 E044 216.434409 0.0040907804 1.535501e-06 1.224619e-05 7 2379512 2380180 669 + 2.435 2.223 -0.707
ENSG00000106263 E045 49.206156 0.0005113813 6.227639e-01 7.394918e-01 7 2380181 2380203 23 + 1.695 1.653 -0.141
ENSG00000106263 E046 1211.100271 0.0001374252 3.030274e-71 4.744433e-68 7 2380204 2380278 75 + 2.884 3.099 0.716
ENSG00000106263 E047 1024.864674 0.0003396320 5.666629e-52 3.847763e-49 7 2380279 2380283 5 + 2.806 3.027 0.736
ENSG00000106263 E048 2451.397330 0.0009911012 1.741010e-35 4.391865e-33 7 2380284 2380414 131 + 3.203 3.397 0.647
ENSG00000106263 E049 2782.971143 0.0015175344 1.746623e-22 1.473909e-20 7 2380415 2380913 499 + 3.271 3.449 0.590