ENSG00000106261

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324306 ENSG00000106261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN1 protein_coding protein_coding 10.32407 5.435535 13.73955 0.3739526 0.6017587 1.336238 5.5126317 0.0000000 8.71804324 0.00000000 0.30961678 9.7695144 0.45152083 0.00000000 0.637300000 0.63730000 2.979896e-33 2.979896e-33 FALSE TRUE
ENST00000482979 ENSG00000106261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN1 protein_coding retained_intron 10.32407 5.435535 13.73955 0.3739526 0.6017587 1.336238 0.7503245 0.7049275 0.49476670 0.08634947 0.15590305 -0.5021802 0.09156667 0.13246667 0.035233333 -0.09723333 3.184180e-03 2.979896e-33 FALSE TRUE
ENST00000535170 ENSG00000106261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN1 protein_coding protein_coding 10.32407 5.435535 13.73955 0.3739526 0.6017587 1.336238 0.8247603 2.0607773 0.03023163 0.07729376 0.03023163 -5.6856985 0.12636250 0.38226667 0.002366667 -0.37990000 4.825816e-32 2.979896e-33 FALSE TRUE
MSTRG.30316.4 ENSG00000106261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN1 protein_coding   10.32407 5.435535 13.73955 0.3739526 0.6017587 1.336238 1.7055297 0.4197833 2.98316674 0.12051773 0.28101606 2.7999914 0.14542917 0.07566667 0.217733333 0.14206667 3.777525e-03 2.979896e-33 TRUE TRUE
MSTRG.30316.7 ENSG00000106261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZKSCAN1 protein_coding   10.32407 5.435535 13.73955 0.3739526 0.6017587 1.336238 0.4150033 1.5120899 0.00000000 0.09446753 0.00000000 -7.2499098 0.07468333 0.28216667 0.000000000 -0.28216667 1.836481e-27 2.979896e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106261 E001 0.3729606 0.0256319077 4.663857e-01 6.059410e-01 7 100015572 100015592 21 + 0.064 0.221 2.054
ENSG00000106261 E002 0.3729606 0.0256319077 4.663857e-01 6.059410e-01 7 100015593 100015595 3 + 0.064 0.221 2.054
ENSG00000106261 E003 0.5244761 0.2331592579 7.808557e-01 8.592134e-01 7 100015596 100015598 3 + 0.121 0.224 1.070
ENSG00000106261 E004 0.9726796 0.2876382899 7.011055e-01 8.003975e-01 7 100015599 100015605 7 + 0.256 0.224 -0.250
ENSG00000106261 E005 1.1199286 0.0781331969 4.590803e-01 5.993109e-01 7 100015606 100015608 3 + 0.292 0.222 -0.528
ENSG00000106261 E006 1.4488820 0.0156374130 7.449200e-01 8.330944e-01 7 100015609 100015609 1 + 0.326 0.367 0.246
ENSG00000106261 E007 10.4784533 0.0019013253 1.610662e-02 4.297376e-02 7 100015610 100015620 11 + 1.012 0.882 -0.484
ENSG00000106261 E008 34.7715252 0.0006447409 1.414022e-05 9.070298e-05 7 100015621 100015726 106 + 1.505 1.372 -0.461
ENSG00000106261 E009 0.7342825 0.0167639177 1.576393e-01 2.719757e-01 7 100016822 100016930 109 + 0.255 0.000 -13.916
ENSG00000106261 E010 1.9219509 0.0075936546 4.012732e-01 5.449697e-01 7 100019231 100019349 119 + 0.415 0.367 -0.269
ENSG00000106261 E011 0.8094091 0.0159876961 5.346529e-01 6.666645e-01 7 100023408 100023418 11 + 0.170 0.367 1.467
ENSG00000106261 E012 31.8254672 0.0006292261 4.472030e-08 4.870023e-07 7 100023419 100023461 43 + 1.485 1.228 -0.895
ENSG00000106261 E013 50.5287579 0.0007513046 1.210414e-06 9.877179e-06 7 100023462 100023551 90 + 1.660 1.550 -0.377
ENSG00000106261 E014 94.0355753 0.0013162467 6.373852e-04 2.671181e-03 7 100023552 100023836 285 + 1.894 1.927 0.111
ENSG00000106261 E015 53.4715459 0.0007935689 1.755834e-02 4.617209e-02 7 100023837 100023932 96 + 1.643 1.694 0.171
ENSG00000106261 E016 68.0163959 0.0022609015 2.154550e-03 7.703558e-03 7 100024154 100024307 154 + 1.755 1.774 0.063
ENSG00000106261 E017 10.5275471 0.0055698561 3.445301e-12 7.747204e-11 7 100024308 100024960 653 + 0.588 1.488 3.371
ENSG00000106261 E018 51.6022582 0.0024306210 9.996672e-10 1.482574e-08 7 100029861 100029952 92 + 1.685 1.460 -0.769
ENSG00000106261 E019 58.4726201 0.0004500965 7.231785e-09 9.145184e-08 7 100030249 100030375 127 + 1.726 1.581 -0.494
ENSG00000106261 E020 21.9123652 0.0018423547 1.027471e-05 6.811947e-05 7 100030851 100031100 250 + 1.332 1.088 -0.862
ENSG00000106261 E021 144.1562701 0.0004420998 4.117422e-28 5.860505e-26 7 100033305 100033825 521 + 2.128 1.891 -0.794
ENSG00000106261 E022 79.0576128 0.0025784916 2.463728e-10 4.060425e-09 7 100033826 100034077 252 + 1.858 1.694 -0.554
ENSG00000106261 E023 1600.0354560 0.0055585279 4.948401e-18 2.509261e-16 7 100034078 100041689 7612 + 3.044 3.330 0.953
ENSG00000106261 E024 3.5603064 0.0186650268 2.802709e-07 2.609548e-06 7 100044784 100044979 196 + 0.170 1.090 4.558