ENSG00000106236

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265634 ENSG00000106236 HEK293_OSMI2_2hA HEK293_TMG_2hB NPTX2 protein_coding protein_coding 14.31181 18.93336 11.44405 0.3966516 0.2762768 -0.7258343 5.9426999 5.538016 6.1850170 1.4238894 0.4022351 0.1591363 0.42217083 0.28970000 0.5416667 0.251966667 0.046099707 0.005620857 FALSE TRUE
MSTRG.30281.2 ENSG00000106236 HEK293_OSMI2_2hA HEK293_TMG_2hB NPTX2 protein_coding   14.31181 18.93336 11.44405 0.3966516 0.2762768 -0.7258343 0.7599167 0.981877 0.7146165 0.5492938 0.5315853 -0.4529436 0.05163333 0.05263333 0.0605000 0.007866667 1.000000000 0.005620857 FALSE FALSE
MSTRG.30281.3 ENSG00000106236 HEK293_OSMI2_2hA HEK293_TMG_2hB NPTX2 protein_coding   14.31181 18.93336 11.44405 0.3966516 0.2762768 -0.7258343 7.1728724 11.811424 4.2227404 0.7835143 0.2448513 -1.4817399 0.49609167 0.62606667 0.3695333 -0.256533333 0.005620857 0.005620857 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106236 E001 24.821587 0.0344103919 4.412935e-05 2.519642e-04 7 98617285 98617625 341 + 1.609 1.192 -1.445
ENSG00000106236 E002 19.201818 0.0207923564 6.023602e-06 4.210743e-05 7 98617626 98617676 51 + 1.510 1.077 -1.520
ENSG00000106236 E003 74.332668 0.0091004184 3.167064e-03 1.075908e-02 7 98617677 98617887 211 + 1.939 1.793 -0.492
ENSG00000106236 E004 36.506855 0.0215551536 6.977223e-01 7.977858e-01 7 98619643 98619648 6 + 1.542 1.545 0.009
ENSG00000106236 E005 45.939217 0.0121835053 9.622774e-01 9.802055e-01 7 98619649 98619666 18 + 1.622 1.651 0.099
ENSG00000106236 E006 123.979115 0.0003725001 3.407961e-01 4.847312e-01 7 98619667 98619859 193 + 2.069 2.067 -0.009
ENSG00000106236 E007 7.407363 0.0034774718 5.638084e-01 6.912241e-01 7 98619860 98620175 316 + 0.831 0.927 0.367
ENSG00000106236 E008 165.258703 0.0002850784 1.930197e-02 4.999003e-02 7 98624922 98625166 245 + 2.220 2.185 -0.119
ENSG00000106236 E009 173.302150 0.0002534715 9.846944e-02 1.881694e-01 7 98627165 98627344 180 + 2.227 2.211 -0.052
ENSG00000106236 E010 709.122762 0.0031242182 5.333620e-07 4.692511e-06 7 98628402 98629869 1468 + 2.747 2.864 0.388