ENSG00000106100

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222823 ENSG00000106100 HEK293_OSMI2_2hA HEK293_TMG_2hB NOD1 protein_coding protein_coding 2.626845 3.069034 1.830981 0.1171509 0.07332326 -0.7420035 0.9277105 1.34290734 0.5965527 0.17312634 0.30362716 -1.157358 0.33967917 0.43703333 0.3131000 -0.1239333 7.910483e-01 7.469749e-08 FALSE TRUE
ENST00000434755 ENSG00000106100 HEK293_OSMI2_2hA HEK293_TMG_2hB NOD1 protein_coding nonsense_mediated_decay 2.626845 3.069034 1.830981 0.1171509 0.07332326 -0.7420035 0.1930179 0.04176097 0.2429755 0.02341024 0.08427431 2.289061 0.08826250 0.01386667 0.1364000 0.1225333 2.541277e-02 7.469749e-08 TRUE TRUE
MSTRG.29665.12 ENSG00000106100 HEK293_OSMI2_2hA HEK293_TMG_2hB NOD1 protein_coding   2.626845 3.069034 1.830981 0.1171509 0.07332326 -0.7420035 0.1693162 0.64661106 0.0000000 0.11374238 0.00000000 -6.036967 0.04667917 0.20873333 0.0000000 -0.2087333 7.469749e-08 7.469749e-08 FALSE TRUE
MSTRG.29665.3 ENSG00000106100 HEK293_OSMI2_2hA HEK293_TMG_2hB NOD1 protein_coding   2.626845 3.069034 1.830981 0.1171509 0.07332326 -0.7420035 0.1410357 0.04392493 0.2462410 0.02582923 0.10606797 2.248477 0.06532083 0.01463333 0.1339667 0.1193333 5.624374e-02 7.469749e-08 TRUE TRUE
MSTRG.29665.4 ENSG00000106100 HEK293_OSMI2_2hA HEK293_TMG_2hB NOD1 protein_coding   2.626845 3.069034 1.830981 0.1171509 0.07332326 -0.7420035 0.2758911 0.00000000 0.3514073 0.00000000 0.28788040 5.175554 0.13037500 0.00000000 0.2051000 0.2051000 2.538769e-01 7.469749e-08 FALSE TRUE
MSTRG.29665.5 ENSG00000106100 HEK293_OSMI2_2hA HEK293_TMG_2hB NOD1 protein_coding   2.626845 3.069034 1.830981 0.1171509 0.07332326 -0.7420035 0.3145461 0.71966469 0.1217887 0.17901244 0.12178866 -2.469007 0.10915417 0.23830000 0.0648000 -0.1735000 2.104605e-01 7.469749e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106100 E001 0.2955422 0.0287653594 0.7482594298   7 30423509 30423913 405 - 0.148 0.101 -0.632
ENSG00000106100 E002 0.0000000       7 30423914 30424088 175 -      
ENSG00000106100 E003 0.1472490 0.0425201282 0.3243287827   7 30424089 30424262 174 - 0.148 0.000 -11.702
ENSG00000106100 E004 0.1472490 0.0425201282 0.3243287827   7 30424263 30424526 264 - 0.148 0.000 -11.702
ENSG00000106100 E005 0.0000000       7 30424527 30424529 3 -      
ENSG00000106100 E006 0.3697384 0.0274424043 0.3453261101 0.489436323 7 30424530 30424533 4 - 0.000 0.183 10.831
ENSG00000106100 E007 60.0029323 0.0191069555 0.0059892867 0.018581972 7 30424534 30425208 675 - 1.619 1.829 0.712
ENSG00000106100 E008 49.7766932 0.0005667172 0.0040811060 0.013371034 7 30425209 30425710 502 - 1.587 1.733 0.496
ENSG00000106100 E009 0.6234634 0.0188136513 0.5584027028 0.686643409 7 30428504 30428609 106 - 0.148 0.251 0.953
ENSG00000106100 E010 20.0249282 0.0010035778 0.4658891999 0.605483373 7 30429374 30429457 84 - 1.335 1.280 -0.193
ENSG00000106100 E011 17.9039297 0.0021893243 0.8040201189 0.875297089 7 30433096 30433179 84 - 1.235 1.256 0.073
ENSG00000106100 E012 0.2924217 0.0290785164 0.1079791761   7 30433180 30433414 235 - 0.258 0.000 -12.689
ENSG00000106100 E013 20.7765001 0.0155750925 0.0469179546 0.103678079 7 30435998 30436081 84 - 1.181 1.370 0.663
ENSG00000106100 E014 12.0596156 0.0025659516 0.0003030895 0.001392019 7 30437573 30437656 84 - 0.797 1.195 1.478
ENSG00000106100 E015 16.1708743 0.0011580951 0.8269880446 0.891165184 7 30446141 30446224 84 - 1.203 1.223 0.068
ENSG00000106100 E016 0.7374030 0.0158090277 0.0651894320 0.135350733 7 30446225 30446966 742 - 0.418 0.101 -2.631
ENSG00000106100 E017 9.1709406 0.0201107983 0.8294097782 0.892881015 7 30446967 30447014 48 - 1.013 0.992 -0.078
ENSG00000106100 E018 12.4851138 0.0015167634 0.9602550333 0.978982340 7 30447015 30447050 36 - 1.119 1.115 -0.014
ENSG00000106100 E019 2.9904061 0.0051176390 0.3608159486 0.505176994 7 30447051 30447148 98 - 0.667 0.526 -0.629
ENSG00000106100 E020 3.3569103 0.0049289394 0.3375178139 0.481398361 7 30447149 30447977 829 - 0.703 0.558 -0.629
ENSG00000106100 E021 14.0256730 0.0013508828 0.1125923737 0.209341725 7 30448298 30448381 84 - 1.245 1.106 -0.495
ENSG00000106100 E022 34.7901875 0.0006469759 0.7376810390 0.827783989 7 30451216 30451718 503 - 1.524 1.544 0.070
ENSG00000106100 E023 11.2947543 0.0080046734 0.4831201171 0.621186757 7 30451719 30451853 135 - 1.119 1.049 -0.254
ENSG00000106100 E024 24.7807089 0.0588659254 0.2617337146 0.399415731 7 30451854 30452378 525 - 1.462 1.338 -0.426
ENSG00000106100 E025 16.4879284 0.0011424559 0.1678694237 0.285420054 7 30452379 30452663 285 - 1.293 1.180 -0.398
ENSG00000106100 E026 7.0886321 0.0672229766 0.4261547757 0.569004298 7 30452664 30452697 34 - 0.977 0.832 -0.551
ENSG00000106100 E027 9.5187574 0.0065962924 0.7490177076 0.836085805 7 30452698 30452833 136 - 1.030 0.995 -0.128
ENSG00000106100 E028 21.8871947 0.0010809611 0.1890833435 0.312580979 7 30452834 30453040 207 - 1.403 1.309 -0.328
ENSG00000106100 E029 18.3885866 0.0841504021 0.3901670206 0.534179150 7 30455137 30455311 175 - 1.351 1.224 -0.443
ENSG00000106100 E030 9.5177153 0.0584079094 0.9218702064 0.954696774 7 30456721 30456742 22 - 1.014 1.016 0.009
ENSG00000106100 E031 10.3061322 0.0095899275 0.8257024411 0.890260888 7 30456743 30456784 42 - 1.030 1.057 0.099
ENSG00000106100 E032 19.4014027 0.0010465813 0.6901826569 0.791938668 7 30456785 30457042 258 - 1.310 1.280 -0.106
ENSG00000106100 E033 6.0400442 0.0028759393 0.7691304247 0.850839187 7 30459152 30459240 89 - 0.850 0.813 -0.144
ENSG00000106100 E034 12.4629223 0.0223006891 0.0243324523 0.060501235 7 30459901 30460041 141 - 1.255 0.998 -0.927
ENSG00000106100 E035 1.7068484 0.0082302366 0.0003674625 0.001648231 7 30463536 30463608 73 - 0.703 0.101 -3.951
ENSG00000106100 E036 8.3705978 0.0753846434 0.1299170848 0.234047185 7 30463609 30463698 90 - 1.092 0.850 -0.901
ENSG00000106100 E037 0.0000000       7 30463986 30464061 76 -      
ENSG00000106100 E038 1.5823248 0.0100188232 0.4949755313 0.631854646 7 30475848 30475988 141 - 0.481 0.363 -0.631
ENSG00000106100 E039 7.4504305 0.0481563651 0.4040191990 0.547740952 7 30478606 30478806 201 - 0.978 0.852 -0.479