ENSG00000106078

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265136 ENSG00000106078 HEK293_OSMI2_2hA HEK293_TMG_2hB COBL protein_coding protein_coding 4.190107 5.375627 3.977221 0.3149671 0.1505092 -0.4337309 1.74624352 2.9740956 1.6968388 0.2901544 0.1162079 -0.805967 0.39717083 0.5510 0.42566667 -0.12533333 0.10992481 0.03058275 FALSE TRUE
ENST00000395542 ENSG00000106078 HEK293_OSMI2_2hA HEK293_TMG_2hB COBL protein_coding protein_coding 4.190107 5.375627 3.977221 0.3149671 0.1505092 -0.4337309 1.15274992 0.3695926 1.5173545 0.3695926 0.1823201 2.008511 0.31310000 0.0632 0.38606667 0.32286667 0.07008109 0.03058275 FALSE TRUE
ENST00000431948 ENSG00000106078 HEK293_OSMI2_2hA HEK293_TMG_2hB COBL protein_coding protein_coding 4.190107 5.375627 3.977221 0.3149671 0.1505092 -0.4337309 0.84724375 1.9519762 0.1549060 0.2405963 0.1549060 -3.572592 0.17702500 0.3701 0.03666667 -0.33343333 0.03058275 0.03058275 FALSE TRUE
MSTRG.29859.1 ENSG00000106078 HEK293_OSMI2_2hA HEK293_TMG_2hB COBL protein_coding   4.190107 5.375627 3.977221 0.3149671 0.1505092 -0.4337309 0.05696641 0.0000000 0.3426483 0.0000000 0.2178623 5.140158 0.01296667 0.0000 0.08753333 0.08753333 0.17045420 0.03058275 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106078 E001 0.3697384 0.0251165331 3.320220e-01 4.756474e-01 7 51016212 51016212 1 - 0.000 0.187 10.006
ENSG00000106078 E002 179.4473436 0.0042894252 5.802031e-12 1.254053e-10 7 51016213 51017191 979 - 2.039 2.321 0.944
ENSG00000106078 E003 53.1255506 0.0103496068 1.575356e-04 7.807014e-04 7 51017192 51017279 88 - 1.516 1.798 0.957
ENSG00000106078 E004 41.9743802 0.0109106904 8.384049e-03 2.474887e-02 7 51017280 51017343 64 - 1.467 1.680 0.726
ENSG00000106078 E005 64.2894552 0.0004598653 5.042570e-04 2.175982e-03 7 51017344 51017568 225 - 1.675 1.849 0.587
ENSG00000106078 E006 26.7798917 0.0135939090 4.281548e-01 5.709504e-01 7 51025109 51025231 123 - 1.362 1.448 0.298
ENSG00000106078 E007 18.3878836 0.0082382233 9.421829e-02 1.817271e-01 7 51025232 51025372 141 - 1.157 1.327 0.599
ENSG00000106078 E008 36.9402461 0.0006800745 6.520159e-02 1.353700e-01 7 51026546 51026665 120 - 1.484 1.606 0.418
ENSG00000106078 E009 47.8313622 0.0012415856 4.727768e-01 6.118304e-01 7 51027712 51027869 158 - 1.642 1.692 0.173
ENSG00000106078 E010 152.2027473 0.0002595140 1.430075e-01 2.521292e-01 7 51027870 51028878 1009 - 2.184 2.156 -0.093
ENSG00000106078 E011 68.9660661 0.0101684520 7.782195e-01 8.572936e-01 7 51028879 51029179 301 - 1.823 1.822 -0.005
ENSG00000106078 E012 71.9075844 0.0040419690 9.642626e-02 1.849955e-01 7 51029180 51029591 412 - 1.887 1.817 -0.237
ENSG00000106078 E013 29.5709331 0.0243204598 3.640844e-03 1.212934e-02 7 51030812 51030909 98 - 1.625 1.348 -0.953
ENSG00000106078 E014 3.3547191 0.0363582294 9.978379e-01 1.000000e+00 7 51030910 51035955 5046 - 0.617 0.627 0.044
ENSG00000106078 E015 45.5000386 0.0005893464 4.147555e-04 1.830969e-03 7 51043383 51043692 310 - 1.748 1.579 -0.573
ENSG00000106078 E016 1.8067782 0.1087936102 5.026928e-01 6.387276e-01 7 51064399 51065449 1051 - 0.526 0.411 -0.578
ENSG00000106078 E017 0.7342825 0.0163968824 5.056343e-03 1.608579e-02 7 51070828 51072715 1888 - 0.472 0.000 -15.380
ENSG00000106078 E018 0.7437457 0.0147610750 7.041959e-02 1.440456e-01 7 51072716 51073385 670 - 0.410 0.104 -2.544
ENSG00000106078 E019 16.0249918 0.0011271102 1.140184e-01 2.113795e-01 7 51083058 51083228 171 - 1.289 1.169 -0.425
ENSG00000106078 E020 20.7564486 0.0176172035 9.982807e-02 1.902211e-01 7 51085166 51085304 139 - 1.410 1.262 -0.518
ENSG00000106078 E021 25.3590272 0.0008308809 2.406626e-02 5.995031e-02 7 51136158 51136331 174 - 1.489 1.348 -0.486
ENSG00000106078 E022 2.1630010 0.0076515528 3.228725e-01 4.662207e-01 7 51172456 51172530 75 - 0.574 0.418 -0.763
ENSG00000106078 E023 18.9557512 0.0010162727 5.745302e-04 2.438677e-03 7 51184102 51184199 98 - 1.424 1.169 -0.892
ENSG00000106078 E024 0.0000000       7 51187914 51187958 45 -      
ENSG00000106078 E025 34.8730971 0.0010291273 3.583834e-03 1.196550e-02 7 51190850 51190997 148 - 1.634 1.475 -0.543
ENSG00000106078 E026 33.2832634 0.0126778685 7.643654e-03 2.288313e-02 7 51190998 51191078 81 - 1.630 1.436 -0.665
ENSG00000106078 E027 43.0808899 0.0052288959 6.137022e-04 2.583530e-03 7 51193379 51193589 211 - 1.739 1.542 -0.668
ENSG00000106078 E028 24.9707913 0.0009108368 6.033588e-04 2.545361e-03 7 51219741 51219944 204 - 1.521 1.299 -0.770
ENSG00000106078 E029 0.0000000       7 51316379 51316592 214 -      
ENSG00000106078 E030 12.9544261 0.0014323090 2.722080e-03 9.438475e-03 7 51316593 51316818 226 - 1.271 1.007 -0.946