ENSG00000106077

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222800 ENSG00000106077 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD11 protein_coding protein_coding 28.53674 53.07857 18.22534 2.559026 1.341822 -1.541664 10.8381938 22.63146215 6.5068202 0.82667766 0.41366746 -1.7967270 0.36609167 0.427100000 0.36173333 -0.06536667 0.48514281 0.02657595 FALSE  
ENST00000395147 ENSG00000106077 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD11 protein_coding protein_coding 28.53674 53.07857 18.22534 2.559026 1.341822 -1.541664 5.9044915 14.17642680 3.6418000 0.30532595 0.20432102 -1.9578316 0.17182500 0.268100000 0.20043333 -0.06766667 0.02657595 0.02657595 FALSE  
ENST00000412965 ENSG00000106077 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD11 protein_coding nonsense_mediated_decay 28.53674 53.07857 18.22534 2.559026 1.341822 -1.541664 1.9088372 3.42103516 1.4164699 0.53410699 0.09878063 -1.2661946 0.07040000 0.064033333 0.07900000 0.01496667 0.66045205 0.02657595 TRUE  
ENST00000458339 ENSG00000106077 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD11 protein_coding protein_coding 28.53674 53.07857 18.22534 2.559026 1.341822 -1.541664 1.8497015 3.52929089 1.5137220 0.30622021 0.16295542 -1.2158606 0.06285417 0.066400000 0.08423333 0.01783333 0.59122879 0.02657595 FALSE  
ENST00000462381 ENSG00000106077 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD11 protein_coding retained_intron 28.53674 53.07857 18.22534 2.559026 1.341822 -1.541664 3.0503079 3.91824021 1.9810266 0.26521591 0.51201266 -0.9803706 0.11653750 0.073700000 0.10723333 0.03353333 0.58623540 0.02657595    
ENST00000486114 ENSG00000106077 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD11 protein_coding retained_intron 28.53674 53.07857 18.22534 2.559026 1.341822 -1.541664 0.7798591 0.05140093 1.1658394 0.05140093 0.64801755 4.2592866 0.03929583 0.001066667 0.06073333 0.05966667 0.25126737 0.02657595 FALSE  
ENST00000497897 ENSG00000106077 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD11 protein_coding retained_intron 28.53674 53.07857 18.22534 2.559026 1.341822 -1.541664 1.7155028 1.31607036 0.7814784 0.40079501 0.24301961 -0.7445354 0.07099583 0.025166667 0.04236667 0.01720000 0.66149741 0.02657595 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106077 E001 203.805246 0.0058168079 0.003452789 0.011589456 7 73736094 73736289 196 - 2.080 2.231 0.504
ENSG00000106077 E002 383.122971 0.0039561158 0.143793137 0.253173157 7 73736290 73736535 246 - 2.429 2.488 0.199
ENSG00000106077 E003 188.431405 0.0002082297 0.180593123 0.301924127 7 73736536 73736563 28 - 2.198 2.162 -0.121
ENSG00000106077 E004 295.466440 0.0003244565 0.812137292 0.880843726 7 73736564 73736662 99 - 2.365 2.364 -0.001
ENSG00000106077 E005 218.127398 0.0015918985 0.857055837 0.911680539 7 73736663 73736691 29 - 2.234 2.235 0.004
ENSG00000106077 E006 25.491901 0.0190376538 0.034346334 0.080426660 7 73736857 73736928 72 - 1.484 1.277 -0.719
ENSG00000106077 E007 309.486133 0.0010269427 0.775633708 0.855459650 7 73736929 73737068 140 - 2.385 2.384 -0.002
ENSG00000106077 E008 170.914656 0.0019304521 0.402491736 0.546236932 7 73737069 73737110 42 - 2.091 2.131 0.133
ENSG00000106077 E009 46.430746 0.0136862412 0.902686935 0.942036784 7 73737111 73737220 110 - 1.549 1.569 0.069
ENSG00000106077 E010 182.302129 0.0003639280 0.653681969 0.764088881 7 73737221 73737360 140 - 2.134 2.155 0.068
ENSG00000106077 E011 92.217078 0.0006475036 0.887990820 0.932409555 7 73737361 73737391 31 - 1.848 1.860 0.040
ENSG00000106077 E012 27.735976 0.0011062609 0.006694554 0.020431801 7 73737392 73737561 170 - 1.502 1.304 -0.684
ENSG00000106077 E013 118.581301 0.0004154212 0.669700354 0.776394371 7 73737562 73737567 6 - 1.975 1.963 -0.040
ENSG00000106077 E014 189.586958 0.0041353131 0.398252249 0.541985095 7 73737568 73737645 78 - 2.134 2.178 0.146
ENSG00000106077 E015 151.287566 0.0007824023 0.336441177 0.480293066 7 73737646 73737669 24 - 2.095 2.066 -0.100
ENSG00000106077 E016 173.307960 0.0003204608 0.683259181 0.786509671 7 73737670 73737713 44 - 2.136 2.128 -0.028
ENSG00000106077 E017 145.991280 0.0002606351 0.399089269 0.542828684 7 73737714 73737735 22 - 2.078 2.053 -0.083
ENSG00000106077 E018 8.282490 0.0592299685 0.026814174 0.065606746 7 73737736 73737875 140 - 1.124 0.796 -1.230
ENSG00000106077 E019 13.620482 0.0439409288 0.001094558 0.004285553 7 73737876 73738072 197 - 1.375 0.953 -1.510
ENSG00000106077 E020 6.359233 0.0392173891 0.013275517 0.036559585 7 73738073 73738142 70 - 1.058 0.691 -1.418
ENSG00000106077 E021 107.151476 0.0002942051 0.937460251 0.964661645 7 73738328 73738332 5 - 1.918 1.926 0.029
ENSG00000106077 E022 201.723123 0.0002562864 0.462970749 0.602823579 7 73738333 73738442 110 - 2.210 2.193 -0.057
ENSG00000106077 E023 71.562598 0.0086166742 0.744638963 0.832893186 7 73738443 73738463 21 - 1.765 1.751 -0.046
ENSG00000106077 E024 2.825656 0.0838478573 0.000195133 0.000942997 7 73738464 73738510 47 - 0.955 0.270 -3.220
ENSG00000106077 E025 118.735917 0.0053052278 0.527980225 0.660900054 7 73738646 73738852 207 - 1.934 1.975 0.140