ENSG00000106070

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335866 ENSG00000106070 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB10 protein_coding protein_coding 21.51795 24.22176 22.15163 0.9185101 0.6352912 -0.1288347 2.3365088 2.0673311 3.0829913 0.6020667 0.1709332 0.5742716 0.10725000 0.08386667 0.13966667 0.05580000 2.392179e-01 7.111347e-07 FALSE TRUE
ENST00000398810 ENSG00000106070 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB10 protein_coding protein_coding 21.51795 24.22176 22.15163 0.9185101 0.6352912 -0.1288347 1.1180771 1.5610191 2.7678647 0.8436110 0.4849157 0.8222756 0.05084583 0.06253333 0.12390000 0.06136667 6.306262e-01 7.111347e-07 FALSE TRUE
ENST00000398812 ENSG00000106070 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB10 protein_coding protein_coding 21.51795 24.22176 22.15163 0.9185101 0.6352912 -0.1288347 11.6334605 13.8821782 8.5302101 0.3939988 0.3744049 -0.7019293 0.54401667 0.57603333 0.38663333 -0.18940000 1.407414e-02 7.111347e-07 FALSE TRUE
ENST00000402497 ENSG00000106070 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB10 protein_coding protein_coding 21.51795 24.22176 22.15163 0.9185101 0.6352912 -0.1288347 0.9525308 0.4383181 1.7340313 0.1347905 0.2949887 1.9598314 0.04337083 0.01783333 0.07826667 0.06043333 4.996816e-04 7.111347e-07 FALSE TRUE
ENST00000428711 ENSG00000106070 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB10 protein_coding protein_coding 21.51795 24.22176 22.15163 0.9185101 0.6352912 -0.1288347 1.3284384 3.0983225 0.7563126 0.2458859 0.1169647 -2.0201314 0.05872083 0.12790000 0.03450000 -0.09340000 7.111347e-07 7.111347e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106070 E001 0.1482932 0.0414564504 5.706112e-01   7 50590063 50590067 5 - 0.000 0.115 9.156
ENSG00000106070 E002 1.7711994 0.1105471379 3.116934e-03 1.061028e-02 7 50590068 50590068 1 - 0.000 0.629 14.383
ENSG00000106070 E003 3.3095039 0.1182599618 1.689341e-01 2.867953e-01 7 50590069 50590078 10 - 0.437 0.755 1.435
ENSG00000106070 E004 668.9146835 0.0058251458 6.792140e-08 7.128811e-07 7 50590079 50591122 1044 - 2.683 2.899 0.722
ENSG00000106070 E005 621.9194303 0.0017537971 4.488779e-01 5.901005e-01 7 50591123 50592347 1225 - 2.788 2.791 0.011
ENSG00000106070 E006 176.0258975 0.0002364435 3.326715e-05 1.956162e-04 7 50592348 50592579 232 - 2.292 2.202 -0.303
ENSG00000106070 E007 84.3042849 0.0003735969 7.931311e-02 1.584230e-01 7 50592580 50592609 30 - 1.953 1.906 -0.158
ENSG00000106070 E008 135.1600986 0.0003083049 5.531067e-01 6.823145e-01 7 50592610 50592689 80 - 2.105 2.144 0.132
ENSG00000106070 E009 86.2987077 0.0003166921 1.957119e-01 3.208521e-01 7 50592690 50592705 16 - 1.893 1.964 0.238
ENSG00000106070 E010 101.6086003 0.0002805312 6.247527e-01 7.410174e-01 7 50592706 50592720 15 - 1.984 2.022 0.129
ENSG00000106070 E011 99.1352024 0.0002712674 7.878320e-01 8.640893e-01 7 50592721 50592727 7 - 1.990 2.001 0.038
ENSG00000106070 E012 98.2492192 0.0002852399 7.954669e-01 8.694029e-01 7 50592728 50592734 7 - 1.987 1.998 0.040
ENSG00000106070 E013 117.7947307 0.0002477967 4.999344e-01 6.361999e-01 7 50592735 50592762 28 - 2.045 2.088 0.145
ENSG00000106070 E014 116.2828023 0.0002879098 7.780546e-01 8.572262e-01 7 50592763 50592781 19 - 2.045 2.075 0.102
ENSG00000106070 E015 185.6672843 0.0027304401 4.047671e-01 5.484684e-01 7 50592782 50592878 97 - 2.235 2.284 0.165
ENSG00000106070 E016 174.6946975 0.0002299527 5.649362e-01 6.921526e-01 7 50592879 50592951 73 - 2.237 2.242 0.018
ENSG00000106070 E017 214.3397779 0.0001771502 7.533283e-01 8.393072e-01 7 50592952 50593098 147 - 2.321 2.335 0.045
ENSG00000106070 E018 108.3427936 0.0002849904 2.491228e-01 3.848803e-01 7 50595437 50595469 33 - 2.000 2.061 0.204
ENSG00000106070 E019 124.2719952 0.0003148751 2.401882e-01 3.743495e-01 7 50595470 50595530 61 - 2.061 2.120 0.199
ENSG00000106070 E020 5.2305177 0.0032494063 3.925898e-03 1.293455e-02 7 50595531 50595840 310 - 0.489 0.920 1.809
ENSG00000106070 E021 145.7636148 0.0002298879 4.359019e-02 9.762651e-02 7 50603998 50604085 88 - 2.186 2.147 -0.127
ENSG00000106070 E022 119.6814256 0.0002449404 5.634894e-02 1.203321e-01 7 50604311 50604377 67 - 2.101 2.060 -0.136
ENSG00000106070 E023 1.9197728 0.0073878517 1.456154e-01 2.556934e-01 7 50604909 50605289 381 - 0.578 0.346 -1.191
ENSG00000106070 E024 158.2354723 0.0004183731 1.519264e-01 2.642854e-01 7 50605290 50605406 117 - 2.210 2.190 -0.069
ENSG00000106070 E025 125.8900846 0.0002563065 1.922267e-01 3.165492e-01 7 50606337 50606414 78 - 2.112 2.091 -0.068
ENSG00000106070 E026 2.1452965 0.0225839483 3.932632e-01 5.371604e-01 7 50606415 50607068 654 - 0.578 0.450 -0.613
ENSG00000106070 E027 149.5390085 0.0004367879 1.039612e-01 1.965366e-01 7 50612741 50612839 99 - 2.188 2.161 -0.093
ENSG00000106070 E028 143.4273642 0.0028715160 9.315948e-01 9.609068e-01 7 50614770 50614880 111 - 2.145 2.161 0.053
ENSG00000106070 E029 134.7254068 0.0035068251 5.367933e-01 6.685022e-01 7 50616210 50616347 138 - 2.101 2.147 0.154
ENSG00000106070 E030 14.3615586 0.0012243289 8.217509e-09 1.029141e-07 7 50617881 50618070 190 - 0.742 1.354 2.257
ENSG00000106070 E031 111.4814102 0.0002886765 7.187481e-01 8.137444e-01 7 50618071 50618139 69 - 2.042 2.051 0.030
ENSG00000106070 E032 134.3572762 0.0008429082 9.175680e-02 1.778736e-01 7 50619170 50619285 116 - 2.145 2.110 -0.117
ENSG00000106070 E033 163.1467327 0.0013820382 7.113367e-01 8.083178e-01 7 50626822 50626978 157 - 2.205 2.213 0.028
ENSG00000106070 E034 136.4112928 0.0008471975 9.102430e-01 9.469381e-01 7 50669722 50669863 142 - 2.117 2.141 0.080
ENSG00000106070 E035 136.0919579 0.0005615167 2.425360e-01 3.771338e-01 7 50674436 50674613 178 - 2.142 2.126 -0.053
ENSG00000106070 E036 75.0570428 0.0010095736 6.575350e-02 1.362919e-01 7 50674614 50674650 37 - 1.910 1.853 -0.192
ENSG00000106070 E037 55.1935418 0.0036071061 4.073533e-02 9.238819e-02 7 50674651 50674658 8 - 1.794 1.702 -0.309
ENSG00000106070 E038 81.4128581 0.0024470361 5.687080e-03 1.778387e-02 7 50703821 50703908 88 - 1.967 1.863 -0.351
ENSG00000106070 E039 10.3266660 0.0018072131 7.624603e-03 2.283584e-02 7 50705140 50705323 184 - 1.183 0.935 -0.906
ENSG00000106070 E040 15.7782688 0.0019678974 5.118053e-02 1.112577e-01 7 50710875 50710990 116 - 1.296 1.149 -0.520
ENSG00000106070 E041 4.5807341 0.1622798750 2.728418e-01 4.118007e-01 7 50726013 50726035 23 - 0.859 0.617 -0.988
ENSG00000106070 E042 3.9375996 0.0649742614 6.292616e-01 7.446571e-01 7 50726912 50727118 207 - 0.714 0.645 -0.288
ENSG00000106070 E043 6.4586988 0.1754781688 6.273636e-01 7.431723e-01 7 50727340 50727435 96 - 0.900 0.830 -0.269
ENSG00000106070 E044 9.9819143 0.0017450007 1.857413e-01 3.084271e-01 7 50727793 50727890 98 - 1.096 0.979 -0.428
ENSG00000106070 E045 0.1515154 0.0433497671 4.162136e-01   7 50729300 50729399 100 - 0.130 0.000 -12.523
ENSG00000106070 E046 19.8647569 0.0009227219 9.760410e-03 2.817303e-02 7 50732272 50732368 97 - 1.410 1.234 -0.613
ENSG00000106070 E047 0.0000000       7 50747579 50747664 86 -      
ENSG00000106070 E048 23.7008142 0.0007936330 3.944530e-02 9.000656e-02 7 50755887 50755891 5 - 1.460 1.336 -0.426
ENSG00000106070 E049 44.6739620 0.0088922672 1.679685e-03 6.217857e-03 7 50755892 50756056 165 - 1.761 1.565 -0.663
ENSG00000106070 E050 0.1472490 0.0435289629 4.163992e-01   7 50756057 50756064 8 - 0.130 0.000 -12.520
ENSG00000106070 E051 0.3268771 0.0292462612 8.962648e-01   7 50761658 50761720 63 - 0.130 0.116 -0.190
ENSG00000106070 E052 1.1373304 0.0109596188 8.902714e-01 9.338880e-01 7 50761721 50762014 294 - 0.310 0.346 0.224
ENSG00000106070 E053 0.7696683 0.0158545212 5.194186e-01 6.535362e-01 7 50779135 50779162 28 - 0.310 0.206 -0.777
ENSG00000106070 E054 0.0000000       7 50779457 50779508 52 -      
ENSG00000106070 E055 1.3577314 0.0113432846 8.044037e-01 8.755738e-01 7 50779509 50779591 83 - 0.379 0.346 -0.189
ENSG00000106070 E056 1.2137046 0.0125779020 5.466594e-01 6.767894e-01 7 50779592 50779717 126 - 0.379 0.282 -0.603
ENSG00000106070 E057 1.2910239 0.0102833212 9.419374e-02 1.816904e-01 7 50779718 50779743 26 - 0.489 0.207 -1.775
ENSG00000106070 E058 0.9986021 0.0121953136 3.029203e-01 4.448335e-01 7 50779744 50779775 32 - 0.379 0.207 -1.190
ENSG00000106070 E059 6.6822247 0.0492923321 1.268146e-01 2.297141e-01 7 50780627 50780736 110 - 1.001 0.769 -0.887
ENSG00000106070 E060 0.2998086 0.0293777256 8.928119e-01   7 50781021 50781129 109 - 0.130 0.115 -0.194
ENSG00000106070 E061 0.1515154 0.0433497671 4.162136e-01   7 50781130 50781225 96 - 0.130 0.000 -12.523
ENSG00000106070 E062 0.0000000       7 50781226 50781308 83 -      
ENSG00000106070 E063 0.0000000       7 50781309 50781416 108 -      
ENSG00000106070 E064 0.0000000       7 50781417 50781500 84 -      
ENSG00000106070 E065 0.1817044 0.0397975452 5.687563e-01   7 50782424 50782910 487 - 0.000 0.116 11.531
ENSG00000106070 E066 2.2531194 0.1168082872 2.843285e-01 4.245599e-01 7 50792442 50792460 19 - 0.616 0.403 -1.034
ENSG00000106070 E067 24.4877283 0.0287048602 1.307918e-02 3.609496e-02 7 50792461 50793223 763 - 1.527 1.289 -0.824
ENSG00000106070 E068 23.6341826 0.0037155954 6.737865e-10 1.032146e-08 7 50793224 50793462 239 - 1.594 1.139 -1.580