ENSG00000106066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265394 ENSG00000106066 HEK293_OSMI2_2hA HEK293_TMG_2hB CPVL protein_coding protein_coding 35.08729 17.93067 48.36299 3.271162 1.099248 1.430968 6.428491 4.335674 6.944505 0.74899673 1.316185 0.678368 0.1889167 0.2433333 0.1444 -0.098933333 0.13100476 0.04997532 FALSE TRUE
ENST00000396276 ENSG00000106066 HEK293_OSMI2_2hA HEK293_TMG_2hB CPVL protein_coding protein_coding 35.08729 17.93067 48.36299 3.271162 1.099248 1.430968 21.756004 11.198430 29.349448 2.62138577 1.630855 1.389241 0.6085875 0.6140333 0.6061 -0.007933333 0.95489412 0.04997532 FALSE TRUE
MSTRG.29645.2 ENSG00000106066 HEK293_OSMI2_2hA HEK293_TMG_2hB CPVL protein_coding   35.08729 17.93067 48.36299 3.271162 1.099248 1.430968 6.229156 2.149628 11.236411 0.08425043 0.621130 2.380610 0.1757958 0.1286000 0.2324 0.103800000 0.04997532 0.04997532 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106066 E001 2.5390861 0.0103784108 0.4672235053 0.6067388108 7 28995235 28995459 225 - 0.586 0.466 -0.570
ENSG00000106066 E002 4.2740471 0.0037977660 0.2369952568 0.3707028007 7 28995460 28995630 171 - 0.766 0.590 -0.742
ENSG00000106066 E003 2.5484476 0.0068328698 0.4271890006 0.5700133769 7 28995631 28995633 3 - 0.505 0.640 0.615
ENSG00000106066 E004 2.9150655 0.0053373910 0.3512237503 0.4954405623 7 28995634 28995636 3 - 0.534 0.686 0.671
ENSG00000106066 E005 171.7537449 0.0073556460 0.0205906208 0.0527296134 7 28995637 28995882 246 - 2.181 2.289 0.359
ENSG00000106066 E006 326.3179257 0.0004806915 0.0001001983 0.0005227548 7 29030577 29030759 183 - 2.470 2.560 0.301
ENSG00000106066 E007 304.7934559 0.0014390897 0.0044141698 0.0143039398 7 29064061 29064234 174 - 2.442 2.526 0.279
ENSG00000106066 E008 157.5266895 0.0009211265 0.2275281746 0.3594440468 7 29066023 29066041 19 - 2.172 2.217 0.153
ENSG00000106066 E009 229.2517785 0.0002240836 0.7962886778 0.8699647707 7 29066042 29066121 80 - 2.344 2.356 0.040
ENSG00000106066 E010 279.3963495 0.0002403385 0.6971382999 0.7973323800 7 29071773 29071904 132 - 2.436 2.433 -0.011
ENSG00000106066 E011 216.8506635 0.0001831203 0.6170074337 0.7349043242 7 29072301 29072382 82 - 2.329 2.322 -0.022
ENSG00000106066 E012 140.0665000 0.0002253264 0.4756307556 0.6143339634 7 29072383 29072397 15 - 2.143 2.127 -0.055
ENSG00000106066 E013 152.1422120 0.0002113713 0.2477387872 0.3832734743 7 29072398 29072423 26 - 2.182 2.153 -0.098
ENSG00000106066 E014 187.5279607 0.0002642968 0.6046600598 0.7251029209 7 29086484 29086550 67 - 2.264 2.255 -0.030
ENSG00000106066 E015 212.0356565 0.0002274744 0.7969410427 0.8704365482 7 29092623 29092702 80 - 2.315 2.314 -0.005
ENSG00000106066 E016 197.4307645 0.0002534296 0.0100572250 0.0289011922 7 29095084 29095142 59 - 2.305 2.240 -0.217
ENSG00000106066 E017 285.7775481 0.0003582318 0.0147312169 0.0398848787 7 29096103 29096217 115 - 2.460 2.407 -0.177
ENSG00000106066 E018 0.1817044 0.0545898739 0.2179256611   7 29096293 29096455 163 - 0.000 0.171 10.782
ENSG00000106066 E019 303.4826619 0.0024642660 0.4242283835 0.5672037050 7 29112704 29112822 119 - 2.479 2.447 -0.106
ENSG00000106066 E020 0.1482932 0.0411597534 0.2210376282   7 29112823 29112921 99 - 0.000 0.170 10.777
ENSG00000106066 E021 0.0000000       7 29113682 29113768 87 -      
ENSG00000106066 E022 143.8863214 0.0002525987 0.9594877156 0.9785654212 7 29120893 29120904 12 - 2.147 2.151 0.013
ENSG00000106066 E023 185.8270860 0.0002320314 0.2709866515 0.4096750390 7 29120905 29120930 26 - 2.268 2.244 -0.082
ENSG00000106066 E024 267.8152899 0.0001789920 0.3675968863 0.5119650878 7 29120931 29121041 111 - 2.422 2.407 -0.050
ENSG00000106066 E025 151.2594804 0.0009725692 0.2932598793 0.4343053138 7 29121042 29121071 30 - 2.179 2.149 -0.103
ENSG00000106066 E026 18.4878903 0.0009661898 0.0121154956 0.0338132631 7 29146341 29146428 88 - 1.344 1.131 -0.753
ENSG00000106066 E027 108.6804074 0.0005349288 0.1597181051 0.2747486868 7 29146429 29146537 109 - 2.041 1.992 -0.161
ENSG00000106066 E028 0.0000000       7 29181290 29181412 123 -      
ENSG00000106066 E029 0.0000000       7 29184421 29184548 128 -      
ENSG00000106066 E030 0.0000000       7 29185513 29185597 85 -      
ENSG00000106066 E031 0.0000000       7 29186447 29186547 101 -      
ENSG00000106066 E032 0.0000000       7 29195077 29195357 281 -      
ENSG00000106066 E033 0.0000000       7 29195358 29195451 94 -