ENSG00000106025

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222747 ENSG00000106025 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN12 protein_coding protein_coding 21.21807 34.89358 18.78686 1.733252 0.4937411 -0.8928831 4.030499 2.360546 5.634021 0.4527806 0.4311744 1.251504 0.2118167 0.0674000 0.29956667 0.23216667 1.037254e-10 1.037254e-10 FALSE TRUE
ENST00000415871 ENSG00000106025 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN12 protein_coding protein_coding 21.21807 34.89358 18.78686 1.733252 0.4937411 -0.8928831 1.237232 0.000000 1.597924 0.0000000 0.8653679 7.329055 0.0664750 0.0000000 0.08683333 0.08683333 1.365273e-01 1.037254e-10 FALSE TRUE
MSTRG.30575.10 ENSG00000106025 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN12 protein_coding   21.21807 34.89358 18.78686 1.733252 0.4937411 -0.8928831 6.368633 15.314152 2.816116 1.6474304 0.8224845 -2.438914 0.2838208 0.4365000 0.14943333 -0.28706667 5.437899e-04 1.037254e-10   FALSE
MSTRG.30575.9 ENSG00000106025 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN12 protein_coding   21.21807 34.89358 18.78686 1.733252 0.4937411 -0.8928831 8.306915 16.197728 6.531564 0.2904528 0.8677236 -1.308974 0.3709167 0.4674667 0.34743333 -0.12003333 2.473900e-01 1.037254e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106025 E001 97.256720 0.0227918999 1.052160e-09 1.554004e-08 7 120787320 120788321 1002 - 2.228 1.720 -1.708
ENSG00000106025 E002 26.022771 0.0400099755 4.921934e-07 4.358038e-06 7 120788322 120788373 52 - 1.709 1.077 -2.200
ENSG00000106025 E003 87.363707 0.0127230232 2.177233e-23 2.009110e-21 7 120788374 120788897 524 - 2.238 1.550 -2.320
ENSG00000106025 E004 36.413234 0.0006421749 2.316385e-32 4.614429e-30 7 120806549 120806692 144 - 1.883 1.122 -2.621
ENSG00000106025 E005 19.417106 0.0106973993 4.336748e-18 2.210936e-16 7 120810463 120810488 26 - 1.648 0.750 -3.235
ENSG00000106025 E006 25.044171 0.0021578239 1.299083e-29 2.105281e-27 7 120810489 120810570 82 - 1.759 0.827 -3.301
ENSG00000106025 E007 1.668152 0.0079732913 9.993987e-03 2.874789e-02 7 120814005 120814247 243 - 0.653 0.189 -2.683
ENSG00000106025 E008 17.205711 0.0064320928 6.388927e-16 2.477206e-14 7 120815729 120815750 22 - 1.579 0.771 -2.912
ENSG00000106025 E009 22.549337 0.0055434708 4.513068e-19 2.590870e-17 7 120815751 120815803 53 - 1.688 0.893 -2.811
ENSG00000106025 E010 39.637122 0.0005474915 4.562203e-33 9.581992e-31 7 120838777 120838912 136 - 1.913 1.181 -2.513
ENSG00000106025 E011 29.024210 0.0016205627 2.141459e-26 2.629248e-24 7 120840027 120840109 83 - 1.793 1.011 -2.721
ENSG00000106025 E012 201.549928 0.0031480430 1.837402e-40 6.555373e-38 7 120855111 120855381 271 - 1.967 2.409 1.476
ENSG00000106025 E013 281.032461 0.0003013753 3.936073e-38 1.204648e-35 7 120856698 120856833 136 - 2.279 2.509 0.768
ENSG00000106025 E014 2.448327 0.0318553646 1.524220e-01 2.649700e-01 7 120857039 120857085 47 - 0.689 0.419 -1.260
ENSG00000106025 E015 2.455714 0.2465422154 5.031455e-01 6.391205e-01 7 120857086 120857199 114 - 0.655 0.451 -0.945
ENSG00000106025 E016 5.858151 0.0028788760 3.716024e-01 5.160684e-01 7 120857233 120857353 121 - 0.782 0.861 0.309
ENSG00000106025 E017 224.891269 0.0017264589 4.056383e-27 5.288848e-25 7 120857820 120857988 169 - 2.150 2.421 0.903
ENSG00000106025 E018 33.778830 0.0018202509 4.688533e-15 1.619082e-13 7 120857989 120858144 156 - 1.141 1.666 1.822
ENSG00000106025 E019 32.130214 0.0007052506 2.859360e-11 5.526393e-10 7 120858204 120858233 30 - 1.198 1.619 1.458
ENSG00000106025 E020 57.275921 0.0099703311 4.944802e-10 7.745807e-09 7 120858234 120858402 169 - 1.462 1.854 1.332