ENSG00000106012

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402050 ENSG00000106012 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCE protein_coding protein_coding 9.277695 11.27733 7.956997 0.6792886 0.2869004 -0.5025964 3.7700860 4.352918 3.500085 1.1788709 0.25632022 -0.3137876 0.3972708 0.3755333 0.4395667 0.06403333 7.859368e-01 5.586753e-18 FALSE TRUE
ENST00000427817 ENSG00000106012 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCE protein_coding protein_coding 9.277695 11.27733 7.956997 0.6792886 0.2869004 -0.5025964 0.8246649 0.000000 1.028683 0.0000000 0.08597961 6.6986116 0.0947250 0.0000000 0.1301333 0.13013333 5.586753e-18 5.586753e-18 FALSE FALSE
ENST00000438376 ENSG00000106012 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCE protein_coding protein_coding 9.277695 11.27733 7.956997 0.6792886 0.2869004 -0.5025964 2.6101113 3.925334 1.836269 0.7448967 0.21014865 -1.0918738 0.2855000 0.3591667 0.2323333 -0.12683333 5.127816e-01 5.586753e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106012 E001 0.0000000       7 2558972 2558978 7 +      
ENSG00000106012 E002 4.7299708 0.1348086971 1.714304e-01 2.900558e-01 7 2558979 2559020 42 + 0.908 0.611 -1.204
ENSG00000106012 E003 8.1118758 0.0871226107 2.997180e-02 7.190342e-02 7 2559021 2559047 27 + 1.145 0.770 -1.406
ENSG00000106012 E004 8.1118758 0.0871226107 2.997180e-02 7.190342e-02 7 2559048 2559051 4 + 1.145 0.770 -1.406
ENSG00000106012 E005 9.7234340 0.0970214294 2.014806e-02 5.179430e-02 7 2559052 2559056 5 + 1.227 0.826 -1.479
ENSG00000106012 E006 13.7567973 0.1432146106 1.648124e-01 2.814448e-01 7 2559057 2559078 22 + 1.305 1.030 -0.983
ENSG00000106012 E007 24.0630528 0.0817457037 2.413554e-01 3.757808e-01 7 2559079 2559137 59 + 1.480 1.306 -0.601
ENSG00000106012 E008 21.0196505 0.0768913145 5.640377e-01 6.914292e-01 7 2559138 2559148 11 + 1.371 1.284 -0.305
ENSG00000106012 E009 34.9347992 0.0255012826 6.686025e-02 1.381536e-01 7 2559149 2559217 69 + 1.635 1.462 -0.593
ENSG00000106012 E010 0.3634088 0.3492154339 4.831424e-01   7 2559424 2559426 3 + 0.000 0.179 16.485
ENSG00000106012 E011 1.0987209 0.0175599511 8.444338e-01 9.031732e-01 7 2559427 2559520 94 + 0.264 0.304 0.276
ENSG00000106012 E012 0.0000000       7 2566559 2566602 44 +      
ENSG00000106012 E013 23.1325908 0.0370543850 3.125998e-01 4.551268e-01 7 2567116 2567163 48 + 1.416 1.313 -0.359
ENSG00000106012 E014 40.4063914 0.0009860226 1.888986e-01 3.123744e-01 7 2568954 2568999 46 + 1.628 1.562 -0.227
ENSG00000106012 E015 0.1482932 0.0420779998 7.871308e-01   7 2571402 2571525 124 + 0.000 0.098 16.489
ENSG00000106012 E016 36.8713829 0.0006103290 2.674790e-02 6.546741e-02 7 2571526 2571545 20 + 1.624 1.503 -0.412
ENSG00000106012 E017 45.6555839 0.0005227502 3.955998e-02 9.021607e-02 7 2571546 2571604 59 + 1.706 1.607 -0.338
ENSG00000106012 E018 51.3512060 0.0015696830 4.613855e-02 1.022903e-01 7 2571605 2571654 50 + 1.754 1.658 -0.323
ENSG00000106012 E019 70.7623207 0.0004784541 6.434044e-01 7.559712e-01 7 2572192 2572326 135 + 1.833 1.821 -0.038
ENSG00000106012 E020 0.1482932 0.0420779998 7.871308e-01   7 2572714 2572821 108 + 0.000 0.098 16.489
ENSG00000106012 E021 47.6880619 0.0004683805 8.188230e-01 8.855247e-01 7 2573418 2573488 71 + 1.661 1.658 -0.010
ENSG00000106012 E022 64.1981106 0.0003844868 3.624950e-01 5.069117e-01 7 2578242 2578355 114 + 1.808 1.776 -0.109
ENSG00000106012 E023 60.2940273 0.0022702780 2.710500e-03 9.405034e-03 7 2578476 2578526 51 + 1.851 1.710 -0.475
ENSG00000106012 E024 0.7739347 0.0148601055 3.061648e-01 4.483385e-01 7 2580110 2580250 141 + 0.353 0.178 -1.315
ENSG00000106012 E025 0.3332198 0.0315308002 7.001299e-01   7 2582027 2582077 51 + 0.152 0.098 -0.728
ENSG00000106012 E026 75.6167162 0.0003987988 2.760416e-05 1.655961e-04 7 2582580 2582650 71 + 1.959 1.797 -0.546
ENSG00000106012 E027 72.5589792 0.0003507711 5.018082e-04 2.166550e-03 7 2583637 2583709 73 + 1.926 1.790 -0.458
ENSG00000106012 E028 62.1908842 0.0004305424 5.647531e-05 3.140046e-04 7 2584236 2584285 50 + 1.878 1.706 -0.582
ENSG00000106012 E029 2.4681056 0.0063084035 9.114141e-01 9.477540e-01 7 2584286 2584666 381 + 0.491 0.516 0.121
ENSG00000106012 E030 102.0574625 0.0003454543 1.139586e-02 3.210899e-02 7 2586208 2586371 164 + 2.036 1.954 -0.274
ENSG00000106012 E031 60.8628738 0.0004015164 4.014305e-01 5.451325e-01 7 2587822 2587877 56 + 1.731 1.779 0.165
ENSG00000106012 E032 0.0000000       7 2589905 2589906 2 +      
ENSG00000106012 E033 92.7834410 0.0023411712 1.088429e-01 2.038330e-01 7 2589907 2590106 200 + 1.890 1.970 0.270
ENSG00000106012 E034 64.0982044 0.0012916506 1.187838e-01 2.182153e-01 7 2593022 2593126 105 + 1.731 1.816 0.288
ENSG00000106012 E035 62.9778395 0.0004729674 4.865033e-03 1.555423e-02 7 2594886 2594976 91 + 1.677 1.821 0.489
ENSG00000106012 E036 1.4329743 0.0095248212 7.727539e-02 1.551215e-01 7 2596899 2597137 239 + 0.546 0.245 -1.728
ENSG00000106012 E037 1.6219638 0.0084493999 6.410113e-01 7.541213e-01 7 2598126 2598384 259 + 0.353 0.442 0.492
ENSG00000106012 E038 82.4302142 0.0003844730 9.857643e-07 8.188998e-06 7 2598465 2598632 168 + 1.731 1.952 0.746
ENSG00000106012 E039 0.4428904 0.4897278176 5.157005e-01 6.503309e-01 7 2598633 2598736 104 + 0.000 0.186 16.378
ENSG00000106012 E040 38.8629862 0.0005979285 9.887486e-04 3.920046e-03 7 2601441 2601464 24 + 1.417 1.631 0.732
ENSG00000106012 E041 7.3075039 0.0025398108 2.354320e-02 5.887028e-02 7 2601465 2601949 485 + 0.679 0.982 1.188
ENSG00000106012 E042 67.1997549 0.0006796225 3.272253e-04 1.489580e-03 7 2604881 2604991 111 + 1.677 1.858 0.612
ENSG00000106012 E043 83.2138905 0.0007303942 2.469051e-04 1.162440e-03 7 2605876 2605997 122 + 1.782 1.949 0.564
ENSG00000106012 E044 90.6483281 0.0002978044 6.755278e-02 1.392868e-01 7 2607124 2607227 104 + 1.878 1.959 0.272
ENSG00000106012 E045 13.4645885 0.0013131007 2.137623e-03 7.651121e-03 7 2607228 2607562 335 + 0.887 1.216 1.203
ENSG00000106012 E046 955.0852143 0.0095720404 2.602033e-01 3.976825e-01 7 2610044 2614733 4690 + 2.920 2.971 0.167