ENSG00000105993

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262177 ENSG00000105993 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB6 protein_coding protein_coding 99.4104 80.24082 129.3046 9.633437 4.224281 0.6882977 48.732657 48.0450050 46.07333 4.8253521 0.3874323 -0.06044164 0.5326875 0.6026333 0.3569000 -0.24573333 5.822489e-06 4.362053e-49 FALSE TRUE
ENST00000417758 ENSG00000105993 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB6 protein_coding protein_coding 99.4104 80.24082 129.3046 9.633437 4.224281 0.6882977 6.184013 0.3192767 15.57135 0.2005268 2.3984629 5.56437562 0.0494125 0.0037000 0.1195333 0.11583333 8.714188e-05 4.362053e-49 FALSE FALSE
ENST00000429029 ENSG00000105993 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB6 protein_coding protein_coding 99.4104 80.24082 129.3046 9.633437 4.224281 0.6882977 24.042692 23.8249941 30.44535 4.9410138 1.7658825 0.35361420 0.2350542 0.2920333 0.2366667 -0.05536667 4.713084e-01 4.362053e-49 FALSE TRUE
ENST00000488001 ENSG00000105993 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB6 protein_coding processed_transcript 99.4104 80.24082 129.3046 9.633437 4.224281 0.6882977 13.996382 0.0000000 30.29556 0.0000000 4.0836757 11.56536689 0.1119750 0.0000000 0.2331333 0.23313333 4.362053e-49 4.362053e-49 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105993 E001 0.0000000       7 157335381 157335406 26 +      
ENSG00000105993 E002 0.4417471 0.6975961722 3.235906e-01 4.668910e-01 7 157336362 157336773 412 + 0.287 0.000 -10.256
ENSG00000105993 E003 0.4386386 0.1265813860 6.232686e-01 7.398918e-01 7 157336966 157337003 38 + 0.211 0.126 -0.900
ENSG00000105993 E004 1.4027854 0.0095204701 1.036678e-01 1.960818e-01 7 157337004 157337009 6 + 0.504 0.224 -1.699
ENSG00000105993 E005 2.5433380 0.0060833639 1.600308e-01 2.751471e-01 7 157337010 157337022 13 + 0.648 0.430 -1.028
ENSG00000105993 E006 2.5433380 0.0060833639 1.600308e-01 2.751471e-01 7 157337023 157337023 1 + 0.648 0.430 -1.028
ENSG00000105993 E007 2.9850850 0.0051218376 4.787492e-02 1.054023e-01 7 157337024 157337024 1 + 0.731 0.430 -1.376
ENSG00000105993 E008 14.0591475 0.0189519596 1.752890e-03 6.449403e-03 7 157337025 157337045 21 + 1.329 0.989 -1.219
ENSG00000105993 E009 21.2170215 0.0079559765 6.778016e-04 2.817869e-03 7 157337046 157337054 9 + 1.474 1.191 -0.989
ENSG00000105993 E010 136.1760143 0.0003046256 7.946596e-08 8.230599e-07 7 157337055 157337144 90 + 2.213 2.060 -0.512
ENSG00000105993 E011 1.1102619 0.0122445811 6.715416e-01 7.777377e-01 7 157337145 157337150 6 + 0.288 0.371 0.522
ENSG00000105993 E012 0.0000000       7 157337525 157337542 18 +      
ENSG00000105993 E013 0.3332198 0.0265789002 9.920536e-01   7 157337543 157337560 18 + 0.118 0.126 0.109
ENSG00000105993 E014 0.7750806 0.0193821709 1.898654e-01 3.135902e-01 7 157337561 157337628 68 + 0.353 0.126 -1.891
ENSG00000105993 E015 0.7750806 0.0193821709 1.898654e-01 3.135902e-01 7 157337629 157337811 183 + 0.353 0.126 -1.891
ENSG00000105993 E016 0.6695470 0.0171864746 2.944737e-01 4.355684e-01 7 157339821 157340057 237 + 0.118 0.304 1.692
ENSG00000105993 E017 128.5765565 0.0002485204 4.838232e-07 4.289739e-06 7 157358547 157358572 26 + 2.186 2.040 -0.486
ENSG00000105993 E018 237.2948704 0.0001711864 8.306101e-10 1.249854e-08 7 157358573 157358637 65 + 2.445 2.317 -0.429
ENSG00000105993 E019 481.5005269 0.0001235673 2.029091e-19 1.215703e-17 7 157363161 157363270 110 + 2.753 2.620 -0.444
ENSG00000105993 E020 529.3208863 0.0001220533 1.295995e-16 5.498820e-15 7 157366502 157366561 60 + 2.786 2.672 -0.382
ENSG00000105993 E021 446.5968584 0.0005332308 3.597713e-07 3.274761e-06 7 157367373 157367483 111 + 2.698 2.611 -0.291
ENSG00000105993 E022 1.4435834 0.0090734310 3.528600e-01 4.971093e-01 7 157368608 157368736 129 + 0.459 0.304 -0.891
ENSG00000105993 E023 1.4102740 0.0138367044 1.757974e-02 4.622258e-02 7 157368737 157368800 64 + 0.545 0.127 -2.890
ENSG00000105993 E024 3.1244101 0.0162115909 1.932476e-04 9.349108e-04 7 157368801 157368942 142 + 0.842 0.224 -3.143
ENSG00000105993 E025 1.2210941 0.0108647759 3.093444e-02 7.378452e-02 7 157369131 157369251 121 + 0.504 0.126 -2.699
ENSG00000105993 E026 1.4382729 0.0090317296 1.042015e-01 1.968930e-01 7 157369360 157369475 116 + 0.504 0.224 -1.698
ENSG00000105993 E027 0.3666179 0.0329894591 9.761417e-01 9.890803e-01 7 157370764 157370789 26 + 0.118 0.127 0.112
ENSG00000105993 E028 0.3666179 0.0329894591 9.761417e-01 9.890803e-01 7 157370790 157370868 79 + 0.118 0.127 0.112
ENSG00000105993 E029 0.9159869 0.0142688473 1.042644e-01 1.969821e-01 7 157372147 157372227 81 + 0.409 0.126 -2.213
ENSG00000105993 E030 16.3622023 0.0485619980 2.763164e-02 6.727755e-02 7 157378125 157381820 3696 + 1.367 1.075 -1.033
ENSG00000105993 E031 2.6291755 0.0099014835 1.670306e-01 2.843333e-01 7 157381821 157381986 166 + 0.648 0.430 -1.027
ENSG00000105993 E032 2.1756864 0.0077665682 8.528002e-01 9.087815e-01 7 157381987 157382245 259 + 0.504 0.481 -0.113
ENSG00000105993 E033 203.1311261 0.0002296694 2.111175e-05 1.301982e-04 7 157382246 157382248 3 + 2.360 2.265 -0.316
ENSG00000105993 E034 583.1787256 0.0001154588 6.739793e-09 8.580294e-08 7 157382249 157382377 129 + 2.807 2.735 -0.241
ENSG00000105993 E035 3.9910344 0.3828554612 2.882298e-01 4.287868e-01 7 157382378 157382743 366 + 0.801 0.552 -1.056
ENSG00000105993 E036 701.9161102 0.0004224506 1.133319e-06 9.301385e-06 7 157384867 157385008 142 + 2.884 2.819 -0.214
ENSG00000105993 E037 472.4633071 0.0022052558 4.510359e-02 1.003870e-01 7 157385541 157385611 71 + 2.701 2.657 -0.145
ENSG00000105993 E038 184.9438089 0.0218063918 5.817050e-02 1.234939e-01 7 157385612 157386324 713 + 2.172 2.343 0.571
ENSG00000105993 E039 356.7325971 0.0020316510 4.720851e-01 6.111429e-01 7 157409795 157410001 207 + 2.562 2.550 -0.040
ENSG00000105993 E040 184.2163385 0.0156446553 2.151955e-02 5.468416e-02 7 157410002 157415529 5528 + 2.181 2.331 0.500
ENSG00000105993 E041 176.2482618 0.0030836160 4.878409e-01 6.254738e-01 7 157416016 157416024 9 + 2.260 2.248 -0.041
ENSG00000105993 E042 2165.0377227 0.0001152306 1.810112e-138 1.558729e-134 7 157416025 157417439 1415 + 3.225 3.423 0.657
ENSG00000105993 E043 1.2242146 0.0105152375 1.709017e-01 2.893500e-01 7 157421215 157421249 35 + 0.460 0.224 -1.477