ENSG00000105939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242351 ENSG00000105939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3HAV1 protein_coding protein_coding 10.62364 12.51945 9.54806 0.9664818 0.1468887 -0.3905338 8.978275 10.299517 8.8169164 0.8253469 0.18173308 -0.2239952 0.8421167 0.8227667 0.92330000 0.1005333 4.151607e-04 7.774485e-07 FALSE TRUE
ENST00000460845 ENSG00000105939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3HAV1 protein_coding protein_coding 10.62364 12.51945 9.54806 0.9664818 0.1468887 -0.3905338 1.426403 2.189473 0.5225995 0.2431577 0.01785516 -2.0460349 0.1355458 0.1749667 0.05473333 -0.1202333 7.774485e-07 7.774485e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105939 E001 1053.289887 0.0085863201 1.183140e-24 1.250097e-22 7 139043515 139045915 2401 - 2.736 3.189 1.505
ENSG00000105939 E002 28.979285 0.0073353101 6.045662e-02 1.273965e-01 7 139045916 139045951 36 - 1.295 1.589 1.015
ENSG00000105939 E003 406.146221 0.0104439856 1.338397e-03 5.104490e-03 7 139045952 139047853 1902 - 2.601 2.616 0.049
ENSG00000105939 E004 53.278002 0.0093369580 6.711650e-06 4.641026e-05 7 139053451 139053581 131 - 1.798 1.653 -0.492
ENSG00000105939 E005 51.143155 0.0076615638 7.608262e-07 6.486195e-06 7 139053965 139054095 131 - 1.790 1.626 -0.554
ENSG00000105939 E006 44.500967 0.0005058196 2.571848e-14 7.961256e-13 7 139055205 139055295 91 - 1.764 1.513 -0.852
ENSG00000105939 E007 42.798790 0.0096302289 7.363058e-23 6.437052e-21 7 139060338 139061035 698 - 0.883 1.902 3.569
ENSG00000105939 E008 69.461629 0.0003648974 2.684992e-03 9.328829e-03 7 139061036 139061138 103 - 1.834 1.863 0.096
ENSG00000105939 E009 79.519273 0.0003693295 2.693838e-07 2.516839e-06 7 139064879 139064999 121 - 1.929 1.881 -0.160
ENSG00000105939 E010 82.995738 0.0003823777 1.819646e-07 1.757553e-06 7 139073856 139074030 175 - 1.948 1.903 -0.154
ENSG00000105939 E011 73.500536 0.0006789848 4.905570e-07 4.344563e-06 7 139076286 139076409 124 - 1.900 1.846 -0.183
ENSG00000105939 E012 53.754448 0.0004611241 2.638829e-06 1.999833e-05 7 139078552 139078653 102 - 1.770 1.700 -0.238
ENSG00000105939 E013 9.215077 0.0019290169 6.970732e-01 7.972957e-01 7 139079104 139079469 366 - 0.961 1.062 0.369
ENSG00000105939 E014 178.191844 0.0139176329 6.426422e-08 6.774993e-07 7 139079470 139080243 774 - 2.327 2.169 -0.529
ENSG00000105939 E015 66.717380 0.0136581010 3.038244e-09 4.117506e-08 7 139083780 139084032 253 - 1.944 1.687 -0.869
ENSG00000105939 E016 40.215928 0.0015712730 6.091472e-16 2.367688e-14 7 139089624 139089759 136 - 1.745 1.426 -1.090
ENSG00000105939 E017 67.468397 0.0013289140 6.322931e-15 2.147088e-13 7 139109024 139109720 697 - 1.926 1.727 -0.671
ENSG00000105939 E018 0.000000       7 139131898 139132122 225 -