ENSG00000105879

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222597 ENSG00000105879 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLL1 protein_coding protein_coding 17.20942 8.888205 29.66936 0.3951618 2.230631 1.737874 1.333571 0.9064122 2.046356 0.45324519 0.2252934 1.166022 0.07874583 0.10446667 0.06933333 -0.03513333 1.0000000000 0.0005055457 FALSE TRUE
ENST00000415884 ENSG00000105879 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLL1 protein_coding protein_coding 17.20942 8.888205 29.66936 0.3951618 2.230631 1.737874 1.652560 0.6347304 4.120997 0.63473042 1.2318052 2.679722 0.09978750 0.06890000 0.14660000 0.07770000 0.2546288314 0.0005055457 FALSE FALSE
ENST00000432748 ENSG00000105879 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLL1 protein_coding nonsense_mediated_decay 17.20942 8.888205 29.66936 0.3951618 2.230631 1.737874 1.442903 0.5934121 2.421234 0.19079900 0.4830891 2.010473 0.07370000 0.06516667 0.08396667 0.01880000 0.8113316039 0.0005055457 FALSE FALSE
ENST00000440859 ENSG00000105879 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLL1 protein_coding protein_coding 17.20942 8.888205 29.66936 0.3951618 2.230631 1.737874 8.116022 5.4357855 12.741305 0.03106837 0.6491517 1.227433 0.51329583 0.61413333 0.43113333 -0.18300000 0.0005055457 0.0005055457 FALSE TRUE
ENST00000479443 ENSG00000105879 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLL1 protein_coding retained_intron 17.20942 8.888205 29.66936 0.3951618 2.230631 1.737874 1.020841 0.2806601 1.874055 0.28066005 0.3703979 2.696436 0.05461250 0.03000000 0.06250000 0.03250000 0.2917097253 0.0005055457   FALSE
ENST00000487517 ENSG00000105879 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLL1 protein_coding retained_intron 17.20942 8.888205 29.66936 0.3951618 2.230631 1.737874 2.486297 0.0000000 4.678152 0.00000000 2.8515433 8.872876 0.10589167 0.00000000 0.14500000 0.14500000 0.2854692345 0.0005055457 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105879 E001 34.6475532 0.0154325783 4.378807e-01 0.5797607016 7 107743949 107744141 193 + 1.540 1.495 -0.155
ENSG00000105879 E002 15.2561686 0.0330723375 5.730080e-01 0.6990176694 7 107744142 107744144 3 + 1.200 1.151 -0.173
ENSG00000105879 E003 16.6515671 0.0250499474 3.913072e-01 0.5352256923 7 107744145 107744154 10 + 1.244 1.166 -0.275
ENSG00000105879 E004 63.3598815 0.0004270336 5.460297e-05 0.0003047391 7 107744155 107744176 22 + 1.835 1.658 -0.596
ENSG00000105879 E005 6.6688739 0.0026321137 5.104264e-01 0.6456432932 7 107744437 107744837 401 + 0.827 0.930 0.393
ENSG00000105879 E006 140.5741216 0.0035382571 8.600745e-04 0.0034736506 7 107748880 107749047 168 + 2.162 2.043 -0.399
ENSG00000105879 E007 1.5177822 0.0085372070 1.183916e-01 0.2176256585 7 107749048 107749316 269 + 0.463 0.176 -1.929
ENSG00000105879 E008 7.1653401 0.0058869492 3.588660e-01 0.5032403740 7 107752545 107752617 73 + 0.914 0.814 -0.385
ENSG00000105879 E009 61.9721700 0.0044146984 2.979397e-03 0.0102024050 7 107753411 107753413 3 + 1.821 1.668 -0.515
ENSG00000105879 E010 123.9691318 0.0013053101 5.088277e-02 0.1107425764 7 107753414 107753511 98 + 2.090 2.041 -0.165
ENSG00000105879 E011 91.9556642 0.0003164134 4.929268e-01 0.6300268249 7 107753895 107753978 84 + 1.948 1.945 -0.010
ENSG00000105879 E012 0.2998086 0.0293992683 5.571768e-01   7 107753979 107754183 205 + 0.083 0.176 1.238
ENSG00000105879 E013 96.5341595 0.0003788345 4.886144e-01 0.6261603107 7 107755418 107755491 74 + 1.967 1.964 -0.010
ENSG00000105879 E014 0.2966881 0.0269157606 5.267867e-01   7 107755492 107755592 101 + 0.153 0.000 -8.782
ENSG00000105879 E015 228.9440861 0.0006587567 5.429881e-01 0.6736837458 7 107758143 107758530 388 + 2.335 2.344 0.027
ENSG00000105879 E016 257.1574431 0.0011375512 1.289168e-01 0.2326543912 7 107758531 107758995 465 + 2.365 2.428 0.210
ENSG00000105879 E017 738.1053815 0.0030325311 3.474067e-04 0.0015698122 7 107758996 107761667 2672 + 2.811 2.905 0.315