ENSG00000105875

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354475 ENSG00000105875 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR91 protein_coding protein_coding 15.84266 16.5354 12.37747 0.7549424 0.06874783 -0.4175478 1.5710052 3.2168667 0.7847011 0.5621331 0.1148566 -2.0216498 0.09935000 0.19796667 0.06330000 -0.13466667 6.163168e-03 4.527346e-06 FALSE TRUE
ENST00000474411 ENSG00000105875 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR91 protein_coding retained_intron 15.84266 16.5354 12.37747 0.7549424 0.06874783 -0.4175478 1.0685173 0.9524484 1.0130849 0.1339088 0.1727161 0.0881448 0.06760833 0.05783333 0.08193333 0.02410000 5.625042e-01 4.527346e-06 FALSE TRUE
ENST00000682339 ENSG00000105875 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR91 protein_coding retained_intron 15.84266 16.5354 12.37747 0.7549424 0.06874783 -0.4175478 0.2397037 0.0000000 0.7273760 0.0000000 0.2470812 6.2043286 0.01653333 0.00000000 0.05866667 0.05866667 4.527346e-06 4.527346e-06 TRUE TRUE
MSTRG.30741.12 ENSG00000105875 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR91 protein_coding   15.84266 16.5354 12.37747 0.7549424 0.06874783 -0.4175478 1.8956869 2.5644090 1.0202848 0.7926154 0.5106148 -1.3211980 0.11740833 0.15406667 0.08210000 -0.07196667 7.169404e-01 4.527346e-06 TRUE TRUE
MSTRG.30741.13 ENSG00000105875 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR91 protein_coding   15.84266 16.5354 12.37747 0.7549424 0.06874783 -0.4175478 3.6187003 3.9740591 2.4296339 0.9773679 0.2369840 -0.7075744 0.23218333 0.24033333 0.19653333 -0.04380000 8.481039e-01 4.527346e-06 FALSE TRUE
MSTRG.30741.20 ENSG00000105875 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR91 protein_coding   15.84266 16.5354 12.37747 0.7549424 0.06874783 -0.4175478 3.7016222 3.0643337 4.0006315 0.3566120 0.2174723 0.3835557 0.23844583 0.18530000 0.32333333 0.13803333 4.756655e-03 4.527346e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105875 E001 2.6401484 0.0460480720 1.414001e-01 2.499564e-01 7 135183839 135183851 13 - 0.701 0.452 -1.139
ENSG00000105875 E002 8.8324444 0.0019434566 1.075372e-01 2.019028e-01 7 135183852 135183889 38 - 0.848 1.040 0.722
ENSG00000105875 E003 16.6412574 0.0249229523 7.680813e-03 2.297912e-02 7 135183890 135184001 112 - 0.994 1.329 1.197
ENSG00000105875 E004 106.7761265 0.0125790245 5.496158e-02 1.179250e-01 7 135184002 135185271 1270 - 1.922 2.059 0.458
ENSG00000105875 E005 142.4127801 0.0023424045 4.944459e-03 1.577675e-02 7 135185272 135185774 503 - 2.059 2.175 0.387
ENSG00000105875 E006 34.6843540 0.0013565375 2.704215e-03 9.386492e-03 7 135185775 135185781 7 - 1.394 1.597 0.697
ENSG00000105875 E007 111.0689925 0.0048164875 2.301847e-04 1.092435e-03 7 135185782 135185923 142 - 1.899 2.088 0.636
ENSG00000105875 E008 252.7504165 0.0044710559 4.048191e-03 1.327582e-02 7 135185924 135186315 392 - 2.306 2.423 0.393
ENSG00000105875 E009 10.5935799 0.1145106116 6.353374e-01 7.496716e-01 7 135186316 135186971 656 - 1.012 1.065 0.194
ENSG00000105875 E010 157.0684883 0.0002331332 3.513344e-03 1.176437e-02 7 135186972 135187169 198 - 2.118 2.211 0.313
ENSG00000105875 E011 57.2159991 0.0043048203 6.222380e-05 3.424288e-04 7 135187170 135188412 1243 - 1.872 1.657 -0.726
ENSG00000105875 E012 5.6441573 0.0030650395 1.440126e-01 2.534770e-01 7 135188413 135188432 20 - 0.917 0.737 -0.701
ENSG00000105875 E013 68.9172710 0.0006612371 9.491203e-03 2.751503e-02 7 135188433 135188449 17 - 1.741 1.866 0.424
ENSG00000105875 E014 99.8924669 0.0003452686 9.841317e-04 3.905010e-03 7 135188450 135188545 96 - 1.892 2.024 0.441
ENSG00000105875 E015 21.7337258 0.0008945464 4.763030e-05 2.697664e-04 7 135188546 135189343 798 - 1.500 1.211 -1.008
ENSG00000105875 E016 105.1495444 0.0008722982 1.191240e-03 4.611485e-03 7 135189344 135189452 109 - 1.914 2.046 0.442
ENSG00000105875 E017 2.1873146 0.0196854497 1.185662e-01 2.178895e-01 7 135189453 135190522 1070 - 0.626 0.365 -1.292
ENSG00000105875 E018 0.1482932 0.0412374788 7.215239e-01   7 135193215 135193230 16 - 0.001 0.101 7.566
ENSG00000105875 E019 119.1103208 0.0003685868 1.656076e-02 4.397485e-02 7 135193231 135193346 116 - 1.997 2.087 0.300
ENSG00000105875 E020 81.2351877 0.0004242619 5.164293e-01 6.510117e-01 7 135193347 135193399 53 - 1.874 1.908 0.114
ENSG00000105875 E021 12.5679220 0.0014236103 1.134968e-01 2.106247e-01 7 135193400 135193477 78 - 1.202 1.061 -0.506
ENSG00000105875 E022 3.2690110 0.0202212038 1.149330e-01 2.127441e-01 7 135193478 135193558 81 - 0.766 0.526 -1.037
ENSG00000105875 E023 100.2076327 0.0017894824 3.634136e-01 5.078191e-01 7 135193578 135193672 95 - 2.008 1.980 -0.093
ENSG00000105875 E024 18.0189693 0.0107955811 5.650468e-04 2.402946e-03 7 135193673 135194355 683 - 1.435 1.125 -1.089
ENSG00000105875 E025 85.4135207 0.0003155070 5.905200e-01 7.133663e-01 7 135194934 135195002 69 - 1.927 1.913 -0.045
ENSG00000105875 E026 82.1107919 0.0003452340 2.643731e-01 4.023384e-01 7 135195003 135195084 82 - 1.927 1.890 -0.122
ENSG00000105875 E027 64.3947285 0.0004963975 3.068089e-01 4.489972e-01 7 135196144 135196184 41 - 1.824 1.786 -0.128
ENSG00000105875 E028 55.4574893 0.0030532682 2.012089e-01 3.277003e-01 7 135196185 135196219 35 - 1.771 1.709 -0.210
ENSG00000105875 E029 87.6396295 0.0031570265 3.421433e-01 4.861400e-01 7 135196220 135196337 118 - 1.951 1.913 -0.128
ENSG00000105875 E030 7.5222277 0.0022932100 5.203290e-03 1.648325e-02 7 135197044 135197423 380 - 1.090 0.777 -1.178
ENSG00000105875 E031 6.6338164 0.0649187118 5.622482e-02 1.201008e-01 7 135197424 135197992 569 - 1.046 0.734 -1.196
ENSG00000105875 E032 104.8733227 0.0077271225 7.489645e-01 8.360481e-01 7 135197993 135198151 159 - 1.988 2.010 0.074
ENSG00000105875 E033 0.5932745 0.0203136912 6.564215e-01 7.659975e-01 7 135198152 135201343 3192 - 0.257 0.183 -0.622
ENSG00000105875 E034 120.3678585 0.0047774961 8.063205e-01 8.768844e-01 7 135204268 135204433 166 - 2.064 2.059 -0.017
ENSG00000105875 E035 3.5513913 0.0065758647 1.774604e-03 6.518408e-03 7 135204434 135204465 32 - 0.872 0.411 -2.032
ENSG00000105875 E036 21.0657166 0.0009345330 8.739901e-19 4.866984e-17 7 135204466 135205927 1462 - 1.633 0.961 -2.364
ENSG00000105875 E037 117.8930811 0.0019698182 2.866629e-01 4.270895e-01 7 135205928 135206058 131 - 2.075 2.040 -0.117
ENSG00000105875 E038 93.3206753 0.0003134072 7.082965e-04 2.928901e-03 7 135207120 135207202 83 - 2.026 1.909 -0.393
ENSG00000105875 E039 139.7975438 0.0018100484 2.559033e-07 2.402027e-06 7 135208791 135208998 208 - 2.232 2.057 -0.586
ENSG00000105875 E040 114.3606221 0.0009657371 3.949641e-03 1.300170e-02 7 135209576 135209755 180 - 2.099 2.003 -0.322
ENSG00000105875 E041 4.6157455 0.2051649563 1.747317e-02 4.598450e-02 7 135210044 135210832 789 - 0.976 0.471 -2.110
ENSG00000105875 E042 2.1830508 0.0096908170 4.031150e-04 1.786575e-03 7 135210833 135211066 234 - 0.766 0.183 -3.202
ENSG00000105875 E043 1.9680621 0.0093231712 6.543217e-05 3.580432e-04 7 135211067 135211379 313 - 0.766 0.101 -4.203
ENSG00000105875 E044 66.1798056 0.0004862381 7.109212e-02 1.451528e-01 7 135211380 135211555 176 - 1.850 1.777 -0.245