ENSG00000105856

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222574 ENSG00000105856 HEK293_OSMI2_2hA HEK293_TMG_2hB HBP1 protein_coding protein_coding 4.057941 1.901501 5.179331 0.2089063 0.3567433 1.440842 0.83229769 0.2640518 0.9812362 0.08790401 0.33378707 1.8547805 0.2288750 0.1468667 0.19900000 0.05213333 0.87809243 0.01980935 FALSE TRUE
ENST00000464009 ENSG00000105856 HEK293_OSMI2_2hA HEK293_TMG_2hB HBP1 protein_coding protein_coding 4.057941 1.901501 5.179331 0.2089063 0.3567433 1.440842 0.05511451 0.0000000 0.2893957 0.00000000 0.16494192 4.9039818 0.0092625 0.0000000 0.05366667 0.05366667 0.36772913 0.01980935 FALSE FALSE
ENST00000468410 ENSG00000105856 HEK293_OSMI2_2hA HEK293_TMG_2hB HBP1 protein_coding protein_coding 4.057941 1.901501 5.179331 0.2089063 0.3567433 1.440842 2.31179952 1.3083365 3.1243164 0.27718459 0.42296766 1.2494321 0.5518750 0.6752667 0.59790000 -0.07736667 0.69960138 0.01980935 FALSE TRUE
ENST00000498408 ENSG00000105856 HEK293_OSMI2_2hA HEK293_TMG_2hB HBP1 protein_coding protein_coding 4.057941 1.901501 5.179331 0.2089063 0.3567433 1.440842 0.38391077 0.3041428 0.2824071 0.04199377 0.03378063 -0.1034418 0.1129750 0.1646333 0.05463333 -0.11000000 0.01980935 0.01980935 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105856 E001 0.2944980 0.3512718606 0.6646919710   7 107168961 107168989 29 + 0.155 0.000 -10.621
ENSG00000105856 E002 1.1812264 0.1033739993 0.2884627598 0.429059139 7 107168990 107168999 10 + 0.399 0.173 -1.624
ENSG00000105856 E003 1.3327418 0.0376972651 0.1861829551 0.308952362 7 107169000 107169002 3 + 0.435 0.173 -1.812
ENSG00000105856 E004 8.0602881 0.0073152203 0.2188811257 0.349055293 7 107169003 107169027 25 + 0.992 0.838 -0.584
ENSG00000105856 E005 3.9312358 0.1151936366 0.4444301388 0.586008592 7 107169028 107169185 158 + 0.724 0.544 -0.779
ENSG00000105856 E006 0.1472490 0.0434947780 1.0000000000   7 107169720 107169766 47 + 0.085 0.000 -12.073
ENSG00000105856 E007 0.1472490 0.0434947780 1.0000000000   7 107169767 107169768 2 + 0.085 0.000 -12.073
ENSG00000105856 E008 0.1472490 0.0434947780 1.0000000000   7 107169769 107169772 4 + 0.085 0.000 -12.073
ENSG00000105856 E009 0.8962933 0.0615472378 0.0882168947 0.172405026 7 107169773 107170130 358 + 0.360 0.000 -14.396
ENSG00000105856 E010 0.0000000       7 107173457 107173591 135 +      
ENSG00000105856 E011 0.4375944 0.0332750094 0.3162711291 0.459022122 7 107174448 107174745 298 + 0.216 0.000 -13.561
ENSG00000105856 E012 0.0000000       7 107179626 107179816 191 +      
ENSG00000105856 E013 0.4502799 0.0263559148 0.3155921248 0.458352675 7 107179817 107179877 61 + 0.216 0.000 -13.572
ENSG00000105856 E014 0.4502799 0.0263559148 0.3155921248 0.458352675 7 107179878 107179878 1 + 0.216 0.000 -13.572
ENSG00000105856 E015 8.8699127 0.0019718177 0.0958146682 0.184108420 7 107179879 107179917 39 + 1.038 0.839 -0.747
ENSG00000105856 E016 20.7594055 0.0009520673 0.0444801178 0.099254701 7 107179918 107180062 145 + 1.373 1.211 -0.569
ENSG00000105856 E017 35.3365156 0.0009510340 0.0465664150 0.103059201 7 107182373 107182601 229 + 1.580 1.455 -0.428
ENSG00000105856 E018 30.4422824 0.0008021709 0.2016436132 0.328226929 7 107185801 107185942 142 + 1.502 1.416 -0.296
ENSG00000105856 E019 30.0326803 0.0006702943 0.0224298906 0.056571260 7 107186361 107186463 103 + 1.520 1.364 -0.536
ENSG00000105856 E020 15.7826367 0.0011680411 0.2695242758 0.408019508 7 107186464 107186472 9 + 1.240 1.139 -0.356
ENSG00000105856 E021 28.8446296 0.0045147085 0.1567525646 0.270768852 7 107186569 107186681 113 + 1.484 1.374 -0.380
ENSG00000105856 E022 28.7392512 0.0008076405 0.4170728289 0.560452800 7 107189292 107189448 157 + 1.432 1.484 0.180
ENSG00000105856 E023 0.4418608 0.0348231660 0.3164173362 0.459178036 7 107189876 107190172 297 + 0.216 0.000 -13.559
ENSG00000105856 E024 19.4392341 0.0010715620 0.0725892054 0.147659314 7 107190173 107190317 145 + 1.234 1.373 0.486
ENSG00000105856 E025 9.4859972 0.0018128560 0.6275089076 0.743304613 7 107195834 107195847 14 + 0.983 1.035 0.192
ENSG00000105856 E026 23.7970930 0.0009006728 0.1749415571 0.294597037 7 107195848 107195981 134 + 1.344 1.440 0.331
ENSG00000105856 E027 34.4742494 0.0009089466 0.2592601999 0.396649250 7 107195982 107196151 170 + 1.511 1.578 0.229
ENSG00000105856 E028 2.9506376 0.0098824725 0.0174250131 0.045880064 7 107196152 107196289 138 + 0.399 0.773 1.709
ENSG00000105856 E029 2.7668700 0.0077333977 0.0343140324 0.080360601 7 107196290 107196369 80 + 0.399 0.735 1.556
ENSG00000105856 E030 7.0888961 0.0024340249 0.0006252056 0.002625656 7 107196370 107197122 753 + 0.707 1.107 1.528
ENSG00000105856 E031 29.5034167 0.0059679175 0.7317852250 0.823377356 7 107200160 107200301 142 + 1.478 1.454 -0.084
ENSG00000105856 E032 3.0386849 0.0062482264 0.1140089872 0.211366142 7 107200302 107201404 1103 + 0.668 0.394 -1.311
ENSG00000105856 E033 77.2333043 0.0029031713 0.0011016918 0.004308675 7 107201414 107202522 1109 + 1.825 1.965 0.470