ENSG00000105835

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222553 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding protein_coding 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 3.5716639 1.4461783 6.418295 0.1073843 0.6008809 2.1422491 0.10031667 0.12410000 0.09643333 -0.02766667 3.846405e-01 2.328489e-25 FALSE TRUE
ENST00000489358 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding protein_coding 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 7.1952924 0.0000000 15.675293 0.0000000 1.6763590 10.6151968 0.10734583 0.00000000 0.23560000 0.23560000 2.328489e-25 2.328489e-25 FALSE TRUE
ENST00000679894 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding processed_transcript 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 0.4136023 1.1852176 0.000000 1.1852176 0.0000000 -6.9011294 0.03426250 0.08926667 0.00000000 -0.08926667 5.420938e-01 2.328489e-25 FALSE TRUE
ENST00000680129 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding nonsense_mediated_decay 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 4.1367316 1.8919991 8.430005 0.6573176 0.7947338 2.1497274 0.11867917 0.16110000 0.12606667 -0.03503333 8.438743e-01 2.328489e-25 FALSE TRUE
ENST00000680152 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding nonsense_mediated_decay 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 1.5688552 2.9799757 1.763731 0.4271821 0.8920507 -0.7533462 0.09117083 0.26300000 0.02550000 -0.23750000 1.296041e-01 2.328489e-25 TRUE TRUE
ENST00000680786 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding protein_coding 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 1.3308614 0.0000000 3.599937 0.0000000 1.9176290 8.4958300 0.03045417 0.00000000 0.05596667 0.05596667 3.674953e-01 2.328489e-25 FALSE TRUE
ENST00000680823 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding protein_coding 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 2.1840185 2.9592062 4.921925 1.0826407 2.5761729 0.7320736 0.08404167 0.26193333 0.07610000 -0.18583333 5.805980e-01 2.328489e-25 FALSE TRUE
ENST00000681878 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding protein_coding 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 2.4620749 0.0000000 2.262404 0.0000000 2.2624039 7.8280755 0.05081250 0.00000000 0.03286667 0.03286667 1.000000e+00 2.328489e-25 FALSE TRUE
ENST00000681887 ENSG00000105835 HEK293_OSMI2_2hA HEK293_TMG_2hB NAMPT protein_coding processed_transcript 38.46481 11.70807 66.68651 1.1278 2.51278 2.508876 12.3178237 0.4034304 18.794714 0.4034304 3.0219366 5.5073061 0.29097917 0.03036667 0.27910000 0.24873333 4.102172e-02 2.328489e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105835 E001 1.3242330 0.4505559812 2.709506e-01 4.096270e-01 7 106248298 106248307 10 - 0.216 0.605 2.231
ENSG00000105835 E002 1.3242330 0.4505559812 2.709506e-01 4.096270e-01 7 106248308 106248308 1 - 0.216 0.605 2.231
ENSG00000105835 E003 1.8756758 0.0898246566 3.309009e-03 1.117357e-02 7 106248309 106248312 4 - 0.217 0.787 2.984
ENSG00000105835 E004 2.1754844 0.0624076075 1.963655e-03 7.112296e-03 7 106248313 106248331 19 - 0.258 0.831 2.834
ENSG00000105835 E005 3.5038701 0.1965968441 2.893793e-02 6.988150e-02 7 106248332 106248367 36 - 0.390 0.981 2.560
ENSG00000105835 E006 28.5280168 0.0114810583 2.771516e-07 2.582790e-06 7 106248368 106248709 342 - 1.256 1.695 1.512
ENSG00000105835 E007 179.3496479 0.0002022920 1.165079e-02 3.270226e-02 7 106248710 106250038 1329 - 2.200 2.117 -0.279
ENSG00000105835 E008 7.1254990 0.0023793501 3.143170e-01 4.570298e-01 7 106250039 106250042 4 - 0.814 0.946 0.507
ENSG00000105835 E009 7.7834058 0.0025038944 1.739212e-01 2.932880e-01 7 106250043 106250047 5 - 0.835 1.006 0.647
ENSG00000105835 E010 7.5609139 0.0025017281 6.580780e-02 1.363865e-01 7 106250048 106250052 5 - 0.803 1.033 0.872
ENSG00000105835 E011 68.1980941 0.0022564748 3.750888e-04 1.677711e-03 7 106250053 106250430 378 - 1.719 1.906 0.629
ENSG00000105835 E012 59.0544009 0.0030190536 2.374164e-01 3.711777e-01 7 106250431 106250551 121 - 1.690 1.761 0.240
ENSG00000105835 E013 49.9667872 0.0085746648 5.769636e-02 1.226746e-01 7 106250552 106250671 120 - 1.601 1.739 0.469
ENSG00000105835 E014 17.6942663 0.0036010016 1.690922e-02 4.473399e-02 7 106250672 106250700 29 - 1.145 1.365 0.772
ENSG00000105835 E015 16.0885834 0.0018930419 5.455026e-03 1.716845e-02 7 106250701 106250744 44 - 1.097 1.353 0.902
ENSG00000105835 E016 85.2525362 0.0013143463 5.200845e-05 2.917633e-04 7 106250745 106250835 91 - 1.815 1.998 0.614
ENSG00000105835 E017 326.9114405 0.0009438232 8.329225e-10 1.252935e-08 7 106250836 106251193 358 - 2.402 2.557 0.515
ENSG00000105835 E018 2.9412021 0.0071830954 1.992483e-02 5.132920e-02 7 106251194 106252513 1320 - 0.419 0.794 1.688
ENSG00000105835 E019 0.6600969 0.1748495711 2.118979e-01 3.407414e-01 7 106252514 106253016 503 - 0.122 0.364 2.015
ENSG00000105835 E020 241.8285673 0.0002649319 3.512482e-04 1.585186e-03 7 106253017 106253151 135 - 2.288 2.382 0.314
ENSG00000105835 E021 2.2175076 0.0065727867 5.071688e-01 6.427637e-01 7 106253152 106254116 965 - 0.493 0.363 -0.692
ENSG00000105835 E022 0.7310603 0.0717312879 1.000000e+00 1.000000e+00 7 106254117 106254363 247 - 0.217 0.218 0.005
ENSG00000105835 E023 242.5532507 0.0007409899 6.723630e-02 1.387611e-01 7 106254364 106254504 141 - 2.300 2.352 0.173
ENSG00000105835 E024 2.9665639 0.0289396723 9.830780e-01 9.934717e-01 7 106254505 106254836 332 - 0.556 0.556 -0.001
ENSG00000105835 E025 14.0797847 0.0055589026 4.034791e-01 5.472554e-01 7 106254837 106257483 2647 - 1.130 1.033 -0.352
ENSG00000105835 E026 2.5956651 0.0060795023 7.190104e-01 8.139698e-01 7 106258725 106258875 151 - 0.493 0.558 0.308
ENSG00000105835 E027 4.9863323 0.0304102232 5.166520e-01 6.511971e-01 7 106258876 106259287 412 - 0.744 0.629 -0.480
ENSG00000105835 E028 0.5901540 0.0199257540 7.993637e-01 8.720168e-01 7 106259879 106259896 18 - 0.172 0.218 0.423
ENSG00000105835 E029 0.4449813 0.0212567565 5.640963e-01 6.914587e-01 7 106259897 106259904 8 - 0.122 0.218 1.008
ENSG00000105835 E030 0.4449813 0.0212567565 5.640963e-01 6.914587e-01 7 106259905 106259927 23 - 0.122 0.218 1.008
ENSG00000105835 E031 1.1792638 0.0119053720 5.911971e-01 7.139931e-01 7 106259928 106260029 102 - 0.329 0.218 -0.799
ENSG00000105835 E032 8.1909287 0.0988926528 4.844266e-01 6.224357e-01 7 106260030 106261489 1460 - 0.927 0.793 -0.519
ENSG00000105835 E033 0.7342825 0.0159622817 3.036949e-01 4.456552e-01 7 106261490 106261587 98 - 0.258 0.000 -14.252
ENSG00000105835 E034 139.2664440 0.0024134725 9.589134e-02 1.842277e-01 7 106261588 106261707 120 - 2.056 2.127 0.237
ENSG00000105835 E035 0.2924217 0.0273577527 1.000000e+00   7 106263150 106263391 242 - 0.122 0.000 -12.850
ENSG00000105835 E036 262.7733017 0.0003671327 2.345708e-01 3.678368e-01 7 106263392 106263606 215 - 2.354 2.321 -0.110
ENSG00000105835 E037 101.6874698 0.0003281652 3.537909e-02 8.238134e-02 7 106263607 106263617 11 - 1.956 1.862 -0.315
ENSG00000105835 E038 2.8151383 0.0053200215 7.357979e-03 2.214759e-02 7 106263618 106265009 1392 - 0.611 0.000 -16.099
ENSG00000105835 E039 0.8899506 0.0139691418 2.209630e-01 3.515892e-01 7 106265010 106265171 162 - 0.295 0.000 -14.523
ENSG00000105835 E040 4.3641285 0.0036516474 9.006553e-03 2.629553e-02 7 106265172 106266690 1519 - 0.744 0.218 -2.797
ENSG00000105835 E041 0.4545463 0.6649736668 1.000000e+00 1.000000e+00 7 106266691 106266769 79 - 0.174 0.000 -12.269
ENSG00000105835 E042 1.3340015 0.0114248389 9.451884e-02 1.821617e-01 7 106266770 106267826 1057 - 0.391 0.000 -15.091
ENSG00000105835 E043 0.4355181 0.5926515870 1.000000e+00 1.000000e+00 7 106268335 106268463 129 - 0.171 0.000 -12.284
ENSG00000105835 E044 197.2736245 0.0071967497 7.384276e-01 8.283126e-01 7 106268464 106268600 137 - 2.227 2.205 -0.073
ENSG00000105835 E045 184.5769114 0.0055361120 3.382219e-01 4.821014e-01 7 106269154 106269312 159 - 2.204 2.153 -0.171
ENSG00000105835 E046 0.4783925 0.0214227585 5.600231e-01 6.880821e-01 7 106269313 106269414 102 - 0.122 0.218 1.010
ENSG00000105835 E047 1.6671076 0.0087141170 3.344001e-01 4.781467e-01 7 106269415 106269990 576 - 0.419 0.218 -1.312
ENSG00000105835 E048 0.7427016 0.0153787590 3.023877e-01 4.442532e-01 7 106269991 106270172 182 - 0.258 0.000 -14.260
ENSG00000105835 E049 0.2966881 0.0269356510 1.000000e+00   7 106270173 106270176 4 - 0.122 0.000 -12.855
ENSG00000105835 E050 0.4482035 0.0272553638 6.279701e-01 7.436324e-01 7 106270177 106270292 116 - 0.172 0.000 -13.420
ENSG00000105835 E051 0.4482035 0.0272553638 6.279701e-01 7.436324e-01 7 106270293 106270332 40 - 0.172 0.000 -13.420
ENSG00000105835 E052 0.7447779 0.1154095319 3.331734e-01 4.768606e-01 7 106270333 106271094 762 - 0.258 0.000 -13.624
ENSG00000105835 E053 1.8174771 0.0390837975 7.857811e-01 8.627789e-01 7 106271095 106272038 944 - 0.419 0.362 -0.316
ENSG00000105835 E054 0.7427016 0.0153787590 3.023877e-01 4.442532e-01 7 106272039 106272106 68 - 0.258 0.000 -14.260
ENSG00000105835 E055 0.4502799 0.0335762072 6.272887e-01 7.430949e-01 7 106272107 106272165 59 - 0.172 0.000 -13.358
ENSG00000105835 E056 0.4396707 0.0330585921 6.276833e-01 7.434368e-01 7 106272166 106272460 295 - 0.172 0.000 -13.362
ENSG00000105835 E057 0.2944980 0.4403122315 1.000000e+00   7 106272461 106272529 69 - 0.122 0.000 -11.818
ENSG00000105835 E058 212.4068549 0.0013608319 1.353964e-02 3.717186e-02 7 106272530 106272655 126 - 2.273 2.185 -0.293
ENSG00000105835 E059 108.5871248 0.0012215569 2.336516e-02 5.851002e-02 7 106272656 106272658 3 - 1.989 1.885 -0.350
ENSG00000105835 E060 0.1515154 0.0437107007 1.000000e+00   7 106273034 106273139 106 - 0.065 0.000 -11.716
ENSG00000105835 E061 185.6463641 0.0044188224 1.432120e-02 3.896178e-02 7 106274946 106275040 95 - 2.222 2.106 -0.389
ENSG00000105835 E062 69.2885133 0.0034991492 1.728561e-01 2.919149e-01 7 106275041 106275043 3 - 1.792 1.709 -0.281
ENSG00000105835 E063 70.7300230 0.0041973260 1.295435e-01 2.335208e-01 7 106275044 106275049 6 - 1.804 1.709 -0.319
ENSG00000105835 E064 0.5138669 0.0207496717 5.611806e-01 6.890507e-01 7 106275050 106275068 19 - 0.122 0.219 1.012
ENSG00000105835 E065 0.6653823 0.0172671820 7.961296e-01 8.698311e-01 7 106275069 106277022 1954 - 0.172 0.218 0.426
ENSG00000105835 E066 126.5020506 0.0055086661 3.001210e-02 7.198367e-02 7 106277023 106277083 61 - 2.057 1.937 -0.404
ENSG00000105835 E067 116.7940917 0.0002722555 2.191352e-03 7.815232e-03 7 106277084 106277144 61 - 2.024 1.896 -0.431
ENSG00000105835 E068 100.5918091 0.0003082618 3.541678e-04 1.596270e-03 7 106277145 106277179 35 - 1.967 1.804 -0.550
ENSG00000105835 E069 9.1571031 0.0271461185 9.034367e-03 2.636455e-02 7 106284348 106284632 285 - 1.010 0.558 -1.822
ENSG00000105835 E070 0.1472490 0.0449300489 1.000000e+00   7 106284664 106284827 164 - 0.065 0.000 -11.706
ENSG00000105835 E071 138.1667567 0.0002641800 7.397062e-05 3.991657e-04 7 106284828 106284931 104 - 2.102 1.947 -0.519
ENSG00000105835 E072 57.6799567 0.0013594602 4.100989e-03 1.342759e-02 7 106284932 106284981 50 - 1.731 1.551 -0.612
ENSG00000105835 E073 33.1254851 0.0008557223 7.464633e-01 8.342147e-01 7 106284982 106285192 211 - 1.468 1.444 -0.085
ENSG00000105835 E074 0.1472490 0.0449300489 1.000000e+00   7 106285318 106285436 119 - 0.065 0.000 -11.706
ENSG00000105835 E075 2.8628307 0.0213514655 2.967909e-01 4.380655e-01 7 106285541 106285966 426 - 0.575 0.363 -1.076