ENSG00000105821

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379263 ENSG00000105821 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC2 protein_coding protein_coding 33.71997 14.62707 47.01775 2.157312 0.8431455 1.683886 14.771883 6.878039 21.579016 0.53408863 1.1871903 1.6481322 0.43403333 0.480700000 0.45843333 -0.02226667 8.854176e-01 7.392687e-09 FALSE TRUE
ENST00000426036 ENSG00000105821 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC2 protein_coding protein_coding 33.71997 14.62707 47.01775 2.157312 0.8431455 1.683886 1.583290 0.000000 2.894072 0.00000000 0.7062611 8.1819336 0.03356667 0.000000000 0.06210000 0.06210000 7.392687e-09 7.392687e-09 FALSE FALSE
ENST00000464253 ENSG00000105821 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC2 protein_coding retained_intron 33.71997 14.62707 47.01775 2.157312 0.8431455 1.683886 2.038133 0.142037 2.933306 0.07114167 0.2948985 4.2749431 0.05363333 0.009333333 0.06263333 0.05330000 1.171910e-04 7.392687e-09 FALSE TRUE
ENST00000475065 ENSG00000105821 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC2 protein_coding retained_intron 33.71997 14.62707 47.01775 2.157312 0.8431455 1.683886 6.545351 4.860940 5.282388 0.95307773 0.9895950 0.1197187 0.22901250 0.330700000 0.11200000 -0.21870000 2.415334e-04 7.392687e-09 FALSE TRUE
MSTRG.30437.5 ENSG00000105821 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC2 protein_coding   33.71997 14.62707 47.01775 2.157312 0.8431455 1.683886 5.739914 1.910088 10.830524 0.95514010 0.6661481 2.4971904 0.16461667 0.127433333 0.23000000 0.10256667 6.816455e-01 7.392687e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105821 E001 9.6334472 0.0017514108 3.995680e-01 5.433082e-01 7 103312289 103312473 185 - 0.959 1.049 0.335
ENSG00000105821 E002 8.6555828 0.0020378254 1.767004e-01 2.969590e-01 7 103312474 103312518 45 - 0.898 1.049 0.563
ENSG00000105821 E003 7.0614394 0.0036839809 2.126608e-02 5.414755e-02 7 103312519 103312521 3 - 0.773 1.049 1.048
ENSG00000105821 E004 22.7613066 0.0008536671 5.004568e-05 2.820552e-04 7 103312522 103312549 28 - 1.225 1.521 1.029
ENSG00000105821 E005 38.8798751 0.0015642734 2.100198e-05 1.296267e-04 7 103312550 103312568 19 - 1.474 1.725 0.853
ENSG00000105821 E006 98.6037318 0.0003415765 4.513757e-11 8.438106e-10 7 103312569 103312643 75 - 1.873 2.113 0.808
ENSG00000105821 E007 2.0025043 0.0070766068 3.339295e-01 4.776902e-01 7 103312644 103312946 303 - 0.501 0.317 -1.015
ENSG00000105821 E008 269.6131329 0.0002485434 6.613278e-24 6.508393e-22 7 103312947 103313101 155 - 2.312 2.538 0.753
ENSG00000105821 E009 269.9643418 0.0001552567 2.696124e-14 8.317417e-13 7 103315764 103315871 108 - 2.335 2.503 0.560
ENSG00000105821 E010 1.0664556 0.0190679400 2.321626e-01 3.650091e-01 7 103315872 103315987 116 - 0.202 0.417 1.448
ENSG00000105821 E011 241.7551322 0.0001688133 6.293138e-10 9.699122e-09 7 103315988 103316088 101 - 2.296 2.441 0.483
ENSG00000105821 E012 13.2828003 0.0012960099 6.330559e-01 7.478178e-01 7 103316089 103316702 614 - 1.141 1.089 -0.186
ENSG00000105821 E013 5.3907284 0.0029489989 1.849755e-01 3.074528e-01 7 103316703 103316829 127 - 0.827 0.625 -0.829
ENSG00000105821 E014 328.2936255 0.0001615659 8.368629e-06 5.659355e-05 7 103316830 103317014 185 - 2.450 2.539 0.298
ENSG00000105821 E015 4.2030692 0.0038423887 6.463588e-01 7.582934e-01 7 103317015 103317350 336 - 0.658 0.724 0.275
ENSG00000105821 E016 192.4613366 0.0013884745 7.584299e-02 1.528502e-01 7 103319609 103319678 70 - 2.233 2.288 0.183
ENSG00000105821 E017 6.3223283 0.0026687770 1.425897e-01 2.515663e-01 7 103319679 103319755 77 - 0.773 0.957 0.706
ENSG00000105821 E018 215.6184775 0.0002559958 2.496479e-01 3.854999e-01 7 103319756 103319844 89 - 2.290 2.318 0.091
ENSG00000105821 E019 260.1062309 0.0001944019 7.247471e-01 8.181990e-01 7 103321932 103322081 150 - 2.376 2.381 0.017
ENSG00000105821 E020 204.9472935 0.0021629239 1.682039e-02 4.453585e-02 7 103322511 103322599 89 - 2.300 2.214 -0.287
ENSG00000105821 E021 140.5710462 0.0022684239 4.717739e-02 1.041474e-01 7 103322600 103322632 33 - 2.137 2.053 -0.280
ENSG00000105821 E022 33.1127171 0.0028389291 2.851560e-01 4.254601e-01 7 103322633 103322702 70 - 1.472 1.542 0.243
ENSG00000105821 E023 117.7128400 0.0077645156 4.161751e-01 5.595600e-01 7 103322703 103322726 24 - 2.053 2.001 -0.173
ENSG00000105821 E024 98.0788599 0.0048847137 6.755897e-01 7.808091e-01 7 103322727 103322736 10 - 1.966 1.939 -0.092
ENSG00000105821 E025 148.0289275 0.0024746501 1.365508e-01 2.432568e-01 7 103322737 103322794 58 - 2.154 2.090 -0.214
ENSG00000105821 E026 109.5090338 0.0002798036 7.308584e-03 2.202095e-02 7 103323598 103323625 28 - 2.036 1.928 -0.360
ENSG00000105821 E027 103.3423889 0.0002871052 1.608152e-01 2.761877e-01 7 103323626 103323663 38 - 1.998 1.939 -0.197
ENSG00000105821 E028 120.2743856 0.0002760367 1.666025e-01 2.837732e-01 7 103324482 103324562 81 - 2.062 2.008 -0.181
ENSG00000105821 E029 0.5922303 0.0180014646 9.775589e-01 9.900384e-01 7 103324563 103324730 168 - 0.202 0.187 -0.140
ENSG00000105821 E030 197.5322258 0.0001901952 2.816573e-07 2.621555e-06 7 103326543 103326684 142 - 2.302 2.148 -0.513
ENSG00000105821 E031 15.6159455 0.0011982632 1.222072e-01 2.230957e-01 7 103327332 103327378 47 - 1.225 1.070 -0.556
ENSG00000105821 E032 192.4412411 0.0002097804 3.099950e-13 8.212506e-12 7 103327656 103327754 99 - 2.308 2.082 -0.755
ENSG00000105821 E033 3.9531904 0.0703224060 4.552695e-03 1.468876e-02 7 103335242 103337735 2494 - 0.443 0.954 2.170
ENSG00000105821 E034 175.0440315 0.0002560777 3.894543e-11 7.360430e-10 7 103337736 103337811 76 - 2.265 2.050 -0.718
ENSG00000105821 E035 183.4996607 0.0003329338 3.852243e-13 1.008284e-11 7 103341764 103341865 102 - 2.289 2.054 -0.784
ENSG00000105821 E036 147.5183770 0.0002737770 1.992776e-08 2.323948e-07 7 103341866 103341954 89 - 2.187 1.990 -0.662
ENSG00000105821 E037 147.1295501 0.0029203953 1.529320e-07 1.498861e-06 7 103344559 103344830 272 - 2.194 1.963 -0.774