ENSG00000105778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318709 ENSG00000105778 HEK293_OSMI2_2hA HEK293_TMG_2hB AVL9 protein_coding protein_coding 7.898339 3.735277 10.98244 0.3925811 0.2682412 1.553367 4.99687463 2.0643581 7.86932796 0.1822281 0.12879084 1.9254076 0.62600417 0.55510000 0.717833333 0.16273333 2.429661e-02 2.259442e-05 FALSE TRUE
ENST00000409301 ENSG00000105778 HEK293_OSMI2_2hA HEK293_TMG_2hB AVL9 protein_coding protein_coding 7.898339 3.735277 10.98244 0.3925811 0.2682412 1.553367 0.32724186 0.2575498 0.29176134 0.1738967 0.14735504 0.1736005 0.04570417 0.07646667 0.025966667 -0.05050000 8.127950e-01 2.259442e-05 FALSE TRUE
ENST00000446718 ENSG00000105778 HEK293_OSMI2_2hA HEK293_TMG_2hB AVL9 protein_coding protein_coding 7.898339 3.735277 10.98244 0.3925811 0.2682412 1.553367 0.38105043 0.3439644 0.27323934 0.1255034 0.17874694 -0.3215827 0.04823333 0.09083333 0.024133333 -0.06670000 3.591626e-01 2.259442e-05 FALSE TRUE
MSTRG.29684.1 ENSG00000105778 HEK293_OSMI2_2hA HEK293_TMG_2hB AVL9 protein_coding   7.898339 3.735277 10.98244 0.3925811 0.2682412 1.553367 0.60788556 0.0000000 0.72581581 0.0000000 0.43169011 6.2012728 0.05993750 0.00000000 0.066433333 0.06643333 3.572162e-01 2.259442e-05 TRUE TRUE
MSTRG.29684.3 ENSG00000105778 HEK293_OSMI2_2hA HEK293_TMG_2hB AVL9 protein_coding   7.898339 3.735277 10.98244 0.3925811 0.2682412 1.553367 0.09880427 0.3577155 0.06435828 0.2794736 0.06435828 -2.3060246 0.01807917 0.08530000 0.005966667 -0.07933333 3.444599e-01 2.259442e-05 TRUE TRUE
MSTRG.29684.8 ENSG00000105778 HEK293_OSMI2_2hA HEK293_TMG_2hB AVL9 protein_coding   7.898339 3.735277 10.98244 0.3925811 0.2682412 1.553367 0.50913016 0.0000000 1.18267010 0.0000000 0.31439136 6.8980512 0.04235000 0.00000000 0.107300000 0.10730000 2.259442e-05 2.259442e-05 FALSE TRUE
MSTRG.29684.9 ENSG00000105778 HEK293_OSMI2_2hA HEK293_TMG_2hB AVL9 protein_coding   7.898339 3.735277 10.98244 0.3925811 0.2682412 1.553367 0.30634666 0.3597857 0.00000000 0.1798930 0.00000000 -5.2086176 0.06275833 0.09010000 0.000000000 -0.09010000 3.095293e-02 2.259442e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105778 E001 0.0000000       7 32495402 32495425 24 +      
ENSG00000105778 E002 0.0000000       7 32495426 32495448 23 +      
ENSG00000105778 E003 0.7405235 0.0160120546 5.829141e-01 7.071283e-01 7 32495449 32495488 40 + 0.204 0.313 0.815
ENSG00000105778 E004 4.5476051 0.1167857935 4.864993e-01 6.242423e-01 7 32495489 32495520 32 + 0.764 0.616 -0.618
ENSG00000105778 E005 4.9946627 0.1240735739 5.464528e-01 6.766265e-01 7 32495521 32495525 5 + 0.793 0.666 -0.520
ENSG00000105778 E006 5.1419117 0.1378440265 5.277544e-01 6.607685e-01 7 32495526 32495527 2 + 0.807 0.665 -0.576
ENSG00000105778 E007 7.6613043 0.0829670064 2.882540e-01 4.288160e-01 7 32495528 32495535 8 + 0.964 0.790 -0.669
ENSG00000105778 E008 15.8603060 0.0588711755 5.217273e-01 6.556137e-01 7 32495536 32495584 49 + 1.226 1.144 -0.291
ENSG00000105778 E009 20.9997070 0.0499732823 6.939997e-01 7.949255e-01 7 32495585 32495631 47 + 1.297 1.357 0.209
ENSG00000105778 E010 38.5995773 0.0116911081 2.372848e-01 3.710301e-01 7 32495632 32495802 171 + 1.594 1.518 -0.260
ENSG00000105778 E011 0.1482932 0.0411597534 1.862850e-01   7 32531615 32539269 7655 + 0.000 0.184 11.186
ENSG00000105778 E012 42.2265257 0.0005486268 1.931583e-02 5.001812e-02 7 32543141 32543254 114 + 1.640 1.515 -0.425
ENSG00000105778 E013 25.0369550 0.0007351733 9.122806e-04 3.657211e-03 7 32543255 32543261 7 + 1.450 1.199 -0.877
ENSG00000105778 E014 46.5107807 0.0004963560 1.426866e-03 5.396058e-03 7 32544694 32544779 86 + 1.692 1.522 -0.579
ENSG00000105778 E015 45.9046543 0.0004883882 2.456146e-02 6.097461e-02 7 32548847 32548918 72 + 1.674 1.562 -0.383
ENSG00000105778 E016 46.7436768 0.0005071398 7.358203e-03 2.214777e-02 7 32551334 32551423 90 + 1.687 1.549 -0.469
ENSG00000105778 E017 35.2276783 0.0006118469 7.810436e-03 2.330289e-02 7 32552229 32552295 67 + 1.573 1.413 -0.550
ENSG00000105778 E018 30.8710507 0.0043663260 1.951815e-01 3.202265e-01 7 32553727 32553767 41 + 1.500 1.420 -0.274
ENSG00000105778 E019 29.7160225 0.0066899153 6.388426e-01 7.524032e-01 7 32554558 32554596 39 + 1.466 1.445 -0.070
ENSG00000105778 E020 42.0713015 0.0006092827 6.791992e-02 1.399144e-01 7 32558559 32558628 70 + 1.634 1.542 -0.312
ENSG00000105778 E021 78.6498642 0.0003486278 6.459173e-02 1.343616e-01 7 32558929 32559222 294 + 1.890 1.827 -0.213
ENSG00000105778 E022 89.8352018 0.0054013721 5.366013e-01 6.683418e-01 7 32559223 32559464 242 + 1.935 1.914 -0.070
ENSG00000105778 E023 63.7722305 0.0004457714 7.039770e-01 8.025993e-01 7 32570020 32570154 135 + 1.771 1.806 0.118
ENSG00000105778 E024 3.9975582 0.1053508656 9.319445e-01 9.611158e-01 7 32570155 32570166 12 + 0.682 0.669 -0.056
ENSG00000105778 E025 2.7388737 0.0115038083 9.073074e-01 9.451385e-01 7 32573110 32573198 89 + 0.532 0.562 0.142
ENSG00000105778 E026 83.3395787 0.0003569715 4.554073e-01 5.959367e-01 7 32573199 32573418 220 + 1.882 1.930 0.161
ENSG00000105778 E027 60.4349278 0.0125941891 3.932726e-01 5.371694e-01 7 32575955 32576072 118 + 1.732 1.815 0.279
ENSG00000105778 E028 0.2903454 0.2920693619 7.238351e-01   7 32580207 32580218 12 + 0.146 0.000 -10.452
ENSG00000105778 E029 43.1990043 0.0040806271 4.176366e-01 5.609597e-01 7 32580219 32580272 54 + 1.598 1.670 0.245
ENSG00000105778 E030 1.1028750 0.0129524370 4.176702e-01 5.609969e-01 7 32580763 32580790 28 + 0.255 0.413 0.988
ENSG00000105778 E031 1.2501240 0.0266750971 5.865867e-01 7.101318e-01 7 32580791 32580801 11 + 0.301 0.413 0.665
ENSG00000105778 E032 59.3620546 0.0074401078 3.473644e-01 4.915714e-01 7 32580802 32580890 89 + 1.729 1.808 0.267
ENSG00000105778 E033 103.9554394 0.0003537921 6.751501e-01 7.805004e-01 7 32583792 32584102 311 + 1.984 2.017 0.111
ENSG00000105778 E034 214.4705640 0.0007389130 1.343522e-04 6.783022e-04 7 32584103 32585452 1350 + 2.329 2.238 -0.307
ENSG00000105778 E035 40.0543726 0.0005182832 1.342782e-01 2.401020e-01 7 32585453 32585535 83 + 1.609 1.536 -0.250
ENSG00000105778 E036 107.3272953 0.0003001287 3.716554e-01 5.161310e-01 7 32585536 32585925 390 + 2.011 1.995 -0.052
ENSG00000105778 E037 450.8542444 0.0013262213 2.603809e-15 9.331893e-14 7 32585926 32588726 2801 + 2.564 2.737 0.577