ENSG00000105750

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300540 ENSG00000105750 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF85 protein_coding protein_coding 0.6193358 0.5520249 0.7554909 0.1613917 0.05168958 0.4457513 0.10219947 0.19869077 0.16295044 0.07304552 0.01181340 -0.2710081 0.18116667 0.4079333 0.2156333 -0.19230000 0.4817482 0.016517 FALSE FALSE
ENST00000328178 ENSG00000105750 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF85 protein_coding protein_coding 0.6193358 0.5520249 0.7554909 0.1613917 0.05168958 0.4457513 0.15091454 0.07916327 0.18920628 0.07916327 0.18920628 1.1597417 0.25105833 0.1253667 0.2223333 0.09696667 1.0000000 0.016517 FALSE TRUE
ENST00000595854 ENSG00000105750 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF85 protein_coding protein_coding 0.6193358 0.5520249 0.7554909 0.1613917 0.05168958 0.4457513 0.11428006 0.19166018 0.00000000 0.09660178 0.00000000 -4.3338543 0.16417500 0.2719667 0.0000000 -0.27196667 0.0165170 0.016517 FALSE FALSE
ENST00000599885 ENSG00000105750 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF85 protein_coding protein_coding 0.6193358 0.5520249 0.7554909 0.1613917 0.05168958 0.4457513 0.03511896 0.00000000 0.09841189 0.00000000 0.05044939 3.4384510 0.04704167 0.0000000 0.1385000 0.13850000 0.3052316 0.016517 FALSE TRUE
ENST00000601023 ENSG00000105750 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF85 protein_coding processed_transcript 0.6193358 0.5520249 0.7554909 0.1613917 0.05168958 0.4457513 0.07187707 0.05218371 0.11452048 0.04073358 0.02548343 1.0017744 0.14632083 0.0691000 0.1520000 0.08290000 0.7759359 0.016517 FALSE TRUE
ENST00000601924 ENSG00000105750 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF85 protein_coding protein_coding 0.6193358 0.5520249 0.7554909 0.1613917 0.05168958 0.4457513 0.05490902 0.03032693 0.19040184 0.03032693 0.09811302 2.3130804 0.08355833 0.1256333 0.2715333 0.14590000 0.6623755 0.016517 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105750 E001 0.0000000       19 20923222 20923250 29 +      
ENSG00000105750 E002 0.0000000       19 20923251 20923252 2 +      
ENSG00000105750 E003 1.9469404 0.011025583 0.541400282 0.67239685 19 20923253 20923275 23 + 0.401 0.491 0.464
ENSG00000105750 E004 2.3135583 0.012130229 0.474085565 0.61294411 19 20923276 20923284 9 + 0.443 0.546 0.507
ENSG00000105750 E005 2.7617619 0.075136630 0.949971497 0.97269027 19 20923285 20923303 19 + 0.548 0.553 0.023
ENSG00000105750 E006 2.7617619 0.075136630 0.949971497 0.97269027 19 20923304 20923309 6 + 0.548 0.553 0.023
ENSG00000105750 E007 4.4902784 0.004059470 0.954575643 0.97552307 19 20923310 20923400 91 + 0.725 0.715 -0.041
ENSG00000105750 E008 2.4660187 0.006346292 0.778677641 0.85759880 19 20923401 20923403 3 + 0.516 0.545 0.139
ENSG00000105750 E009 0.3729606 0.029310674 0.690082373 0.79187156 19 20923404 20923416 13 + 0.098 0.152 0.725
ENSG00000105750 E010 5.0041573 0.004006167 0.424194431 0.56717432 19 20934024 20934150 127 + 0.725 0.809 0.337
ENSG00000105750 E011 2.1598820 0.010574924 0.548986479 0.67877435 19 20934949 20934965 17 + 0.548 0.427 -0.599
ENSG00000105750 E012 1.7901436 0.013255363 0.140717882 0.24899901 19 20934966 20934969 4 + 0.548 0.264 -1.600
ENSG00000105750 E013 3.2022878 0.006729645 0.211060464 0.33978120 19 20934970 20935047 78 + 0.548 0.714 0.722
ENSG00000105750 E014 0.1515154 0.057537976 0.811282591   19 20936592 20936595 4 + 0.098 0.000 -10.568
ENSG00000105750 E015 0.1515154 0.057537976 0.811282591   19 20936596 20936605 10 + 0.098 0.000 -10.568
ENSG00000105750 E016 0.1515154 0.057537976 0.811282591   19 20936606 20936663 58 + 0.098 0.000 -10.568
ENSG00000105750 E017 0.1515154 0.057537976 0.811282591   19 20936664 20936667 4 + 0.098 0.000 -10.568
ENSG00000105750 E018 0.1515154 0.057537976 0.811282591   19 20936668 20937361 694 + 0.098 0.000 -10.568
ENSG00000105750 E019 6.1588914 0.140143653 0.060108251 0.12678931 19 20942801 20943977 1177 + 0.681 1.025 1.339
ENSG00000105750 E020 0.7383454 0.465385154 0.231482196 0.36423565 19 20944252 20944296 45 + 0.098 0.409 2.629
ENSG00000105750 E021 0.1451727 0.042294991 0.815773746   19 20945499 20945709 211 + 0.098 0.000 -10.569
ENSG00000105750 E022 0.0000000       19 20946300 20946340 41 +      
ENSG00000105750 E023 0.0000000       19 20946341 20946389 49 +      
ENSG00000105750 E024 14.9865151 0.064669440 0.006825844 0.02077059 19 20948744 20950697 1954 + 1.306 0.990 -1.133