ENSG00000105726

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291503 ENSG00000105726 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP13A1 protein_coding protein_coding 61.24505 58.74 52.46017 5.146617 0.980584 -0.1630914 22.129165 26.301838 18.585093 1.9726621 0.7825824 -0.5007901 0.36755833 0.45373333 0.3546667 -0.09906667 3.261372e-01 2.051509e-16 FALSE TRUE
ENST00000492774 ENSG00000105726 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP13A1 protein_coding retained_intron 61.24505 58.74 52.46017 5.146617 0.980584 -0.1630914 8.540049 4.909698 9.342694 1.4456482 1.2578675 0.9268123 0.13985417 0.08083333 0.1777667 0.09693333 6.063287e-02 2.051509e-16 FALSE FALSE
ENST00000496082 ENSG00000105726 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP13A1 protein_coding processed_transcript 61.24505 58.74 52.46017 5.146617 0.980584 -0.1630914 1.795966 0.000000 4.957625 0.0000000 1.4014813 8.9564125 0.03164167 0.00000000 0.0949000 0.09490000 2.051509e-16 2.051509e-16 TRUE TRUE
ENST00000497556 ENSG00000105726 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP13A1 protein_coding retained_intron 61.24505 58.74 52.46017 5.146617 0.980584 -0.1630914 5.706637 9.856588 1.900176 2.5331405 0.2150722 -2.3688455 0.09192083 0.16786667 0.0361000 -0.13176667 1.056009e-03 2.051509e-16 FALSE TRUE
MSTRG.16779.8 ENSG00000105726 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP13A1 protein_coding   61.24505 58.74 52.46017 5.146617 0.980584 -0.1630914 7.077508 5.300722 7.810500 0.9031851 0.3470422 0.5583528 0.11700000 0.08903333 0.1487667 0.05973333 3.711250e-04 2.051509e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105726 E001 4.921069 0.0034623800 8.561567e-05 4.545351e-04 19 19645198 19645199 2 - 0.252 0.903 3.151
ENSG00000105726 E002 5.290807 0.0030499378 3.419349e-05 2.005031e-04 19 19645200 19645202 3 - 0.252 0.931 3.258
ENSG00000105726 E003 5.472511 0.0030912686 2.185252e-05 1.342523e-04 19 19645203 19645205 3 - 0.252 0.945 3.309
ENSG00000105726 E004 7.052643 0.0026015131 3.699974e-06 2.714752e-05 19 19645206 19645207 2 - 0.339 1.040 3.075
ENSG00000105726 E005 26.518515 0.0094366677 2.160290e-02 5.485551e-02 19 19645208 19645214 7 - 1.282 1.488 0.717
ENSG00000105726 E006 496.645976 0.0052934909 1.924801e-10 3.234700e-09 19 19645215 19645511 297 - 2.492 2.758 0.884
ENSG00000105726 E007 267.029504 0.0025215484 5.440738e-11 1.003829e-09 19 19645512 19645532 21 - 2.243 2.481 0.792
ENSG00000105726 E008 13.538870 0.0350421931 7.717066e-01 8.526226e-01 19 19645533 19645646 114 - 1.108 1.156 0.171
ENSG00000105726 E009 635.974510 0.0019982303 1.064288e-14 3.485328e-13 19 19645647 19645790 144 - 2.636 2.852 0.718
ENSG00000105726 E010 23.521552 0.0011751860 5.450907e-01 6.754961e-01 19 19645791 19645873 83 - 1.391 1.358 -0.116
ENSG00000105726 E011 568.460002 0.0014897623 4.603190e-13 1.193459e-11 19 19645874 19645985 112 - 2.606 2.796 0.631
ENSG00000105726 E012 8.047667 0.0121279645 9.503719e-01 9.729486e-01 19 19645986 19646204 219 - 0.929 0.945 0.061
ENSG00000105726 E013 620.416307 0.0010333252 5.301203e-09 6.884404e-08 19 19646205 19646347 143 - 2.680 2.818 0.460
ENSG00000105726 E014 42.690949 0.0005005443 3.403098e-01 4.842867e-01 19 19646348 19647128 781 - 1.646 1.605 -0.141
ENSG00000105726 E015 521.613567 0.0003941914 4.270012e-06 3.085088e-05 19 19647129 19647325 197 - 2.632 2.729 0.325
ENSG00000105726 E016 3.953608 0.0340563723 1.561403e-01 2.700010e-01 19 19647326 19647413 88 - 0.787 0.571 -0.910
ENSG00000105726 E017 361.369894 0.0009726160 1.040368e-02 2.975573e-02 19 19647414 19647528 115 - 2.488 2.564 0.251
ENSG00000105726 E018 15.132034 0.0122755538 1.495311e-02 4.037891e-02 19 19647529 19647598 70 - 1.315 1.083 -0.823
ENSG00000105726 E019 392.298370 0.0033754717 2.357180e-02 5.893012e-02 19 19647599 19647759 161 - 2.516 2.606 0.301
ENSG00000105726 E020 296.588707 0.0002736481 1.697182e-01 2.878376e-01 19 19649567 19649663 97 - 2.425 2.468 0.141
ENSG00000105726 E021 395.181590 0.0002832815 5.707597e-03 1.783743e-02 19 19649741 19649940 200 - 2.533 2.600 0.222
ENSG00000105726 E022 44.531477 0.0005226927 9.641000e-02 1.849728e-01 19 19649941 19651139 1199 - 1.683 1.605 -0.266
ENSG00000105726 E023 28.559438 0.0028340185 2.008829e-02 5.167372e-02 19 19651140 19651688 549 - 1.537 1.388 -0.514
ENSG00000105726 E024 359.096055 0.0005439141 7.763821e-01 8.559962e-01 19 19651689 19651797 109 - 2.522 2.541 0.063
ENSG00000105726 E025 386.473572 0.0006421969 9.931143e-01 9.998308e-01 19 19652595 19652720 126 - 2.557 2.570 0.041
ENSG00000105726 E026 6.685930 0.0023831027 1.371823e-06 1.105905e-05 19 19652721 19653396 676 - 1.146 0.567 -2.272
ENSG00000105726 E027 1.207362 0.1300156312 4.397759e-01 5.815180e-01 19 19653718 19653776 59 - 0.410 0.261 -0.934
ENSG00000105726 E028 1.646014 0.1490303612 3.084947e-01 4.507873e-01 19 19653777 19653783 7 - 0.526 0.320 -1.111
ENSG00000105726 E029 345.299483 0.0008339486 1.938836e-01 3.186628e-01 19 19653784 19653894 111 - 2.528 2.510 -0.059
ENSG00000105726 E030 3.338372 0.1329746855 5.214925e-01 6.553666e-01 19 19653895 19653936 42 - 0.528 0.658 0.582
ENSG00000105726 E031 321.476357 0.0022638366 9.356837e-02 1.807012e-01 19 19653969 19654074 106 - 2.510 2.474 -0.120
ENSG00000105726 E032 190.540147 0.0005537332 9.254225e-01 9.570395e-01 19 19654075 19654144 70 - 2.254 2.263 0.030
ENSG00000105726 E033 380.513680 0.0001442005 2.023398e-03 7.299099e-03 19 19654543 19654700 158 - 2.590 2.543 -0.157
ENSG00000105726 E034 360.027748 0.0001677435 9.642755e-13 2.374306e-11 19 19655119 19655239 121 - 2.614 2.487 -0.423
ENSG00000105726 E035 6.005771 0.0026985873 3.401503e-05 1.995987e-04 19 19655240 19655315 76 - 1.080 0.567 -2.034
ENSG00000105726 E036 353.660235 0.0001564295 3.902744e-13 1.020233e-11 19 19655316 19655445 130 - 2.608 2.478 -0.433
ENSG00000105726 E037 150.004821 0.0025768586 7.960722e-04 3.245456e-03 19 19655446 19655453 8 - 2.231 2.116 -0.384
ENSG00000105726 E038 5.304348 0.0211089258 6.358942e-04 2.665757e-03 19 19655454 19655527 74 - 1.019 0.535 -1.960
ENSG00000105726 E039 149.110261 0.0044060256 8.063371e-03 2.394163e-02 19 19655528 19655543 16 - 2.221 2.119 -0.342
ENSG00000105726 E040 241.356285 0.0002037061 1.686491e-04 8.293977e-04 19 19655544 19655654 111 - 2.412 2.335 -0.260
ENSG00000105726 E041 2.631252 0.0062027910 2.231461e-02 5.632900e-02 19 19655655 19655685 31 - 0.727 0.370 -1.686
ENSG00000105726 E042 182.444001 0.0002059710 2.186960e-03 7.801476e-03 19 19655878 19655933 56 - 2.285 2.213 -0.240
ENSG00000105726 E043 5.497208 0.0034011112 4.388600e-01 5.806848e-01 19 19656050 19656053 4 - 0.839 0.747 -0.367
ENSG00000105726 E044 268.196497 0.0004802802 7.159217e-07 6.135958e-06 19 19656054 19656183 130 - 2.473 2.366 -0.357
ENSG00000105726 E045 252.509025 0.0009427071 1.091550e-02 3.095971e-02 19 19656660 19656766 107 - 2.416 2.360 -0.188
ENSG00000105726 E046 73.856105 0.0074813964 5.475137e-05 3.054773e-04 19 19656767 19656846 80 - 1.978 1.757 -0.743
ENSG00000105726 E047 188.465303 0.0013071118 7.254368e-03 2.188650e-02 19 19656847 19656885 39 - 2.299 2.227 -0.239
ENSG00000105726 E048 168.272097 0.0007828194 5.835682e-03 1.817924e-02 19 19656886 19656916 31 - 2.251 2.178 -0.242
ENSG00000105726 E049 37.249376 0.0351051368 4.029477e-03 1.322429e-02 19 19656917 19656993 77 - 1.714 1.437 -0.944
ENSG00000105726 E050 255.463317 0.0033486313 1.235564e-02 3.438723e-02 19 19656994 19657101 108 - 2.436 2.360 -0.251
ENSG00000105726 E051 200.270846 0.0061198306 3.974645e-02 9.055737e-02 19 19657102 19657149 48 - 2.334 2.255 -0.264
ENSG00000105726 E052 247.641245 0.0068389773 1.034406e-02 2.961360e-02 19 19657336 19657408 73 - 2.440 2.337 -0.343
ENSG00000105726 E053 333.114090 0.0064686097 1.244584e-04 6.342262e-04 19 19659601 19659791 191 - 2.596 2.445 -0.506
ENSG00000105726 E054 10.683826 0.0016489423 1.789078e-01 2.997758e-01 19 19659792 19659824 33 - 1.121 0.995 -0.458
ENSG00000105726 E055 129.421268 0.0095830842 9.933899e-03 2.859668e-02 19 19659898 19659940 43 - 2.176 2.044 -0.444
ENSG00000105726 E056 129.307196 0.0023883066 1.024299e-04 5.332813e-04 19 19659941 19659987 47 - 2.179 2.040 -0.467
ENSG00000105726 E057 2.598912 0.0558569815 2.655677e-02 6.506770e-02 19 19660529 19660619 91 - 0.758 0.368 -1.826
ENSG00000105726 E058 1.948931 0.0178845543 7.255833e-02 1.476108e-01 19 19662075 19662116 42 - 0.618 0.318 -1.546
ENSG00000105726 E059 7.897352 0.0070571905 7.104722e-03 2.149937e-02 19 19662347 19662433 87 - 1.094 0.787 -1.156
ENSG00000105726 E060 5.673503 0.0029288059 1.342686e-01 2.400874e-01 19 19662434 19662499 66 - 0.908 0.725 -0.718
ENSG00000105726 E061 2.648681 0.0087642835 1.263330e-01 2.290411e-01 19 19663081 19663270 190 - 0.693 0.460 -1.065
ENSG00000105726 E062 182.238146 0.0026940234 2.363855e-10 3.908748e-09 19 19663271 19664063 793 - 2.367 2.150 -0.722