ENSG00000105717

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251203 ENSG00000105717 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX4 protein_coding protein_coding 3.094115 4.020099 2.480953 0.5603715 0.3527244 -0.6941175 1.1189407 1.9277220 0.5745721 0.16473627 0.02388311 -1.7289087 0.34491667 0.48710000 0.24040000 -0.246700000 0.001700598 0.001700598 FALSE TRUE
ENST00000557978 ENSG00000105717 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX4 protein_coding nonsense_mediated_decay 3.094115 4.020099 2.480953 0.5603715 0.3527244 -0.6941175 0.2333199 0.3229521 0.2140238 0.07984923 0.16418901 -0.5716628 0.07527083 0.08323333 0.07450000 -0.008733333 0.854383570 0.001700598 FALSE TRUE
ENST00000558222 ENSG00000105717 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX4 protein_coding nonsense_mediated_decay 3.094115 4.020099 2.480953 0.5603715 0.3527244 -0.6941175 0.7772635 0.7182585 0.9506322 0.17175536 0.16100056 0.3995335 0.25702917 0.17346667 0.39340000 0.219933333 0.048522783 0.001700598 FALSE TRUE
ENST00000558276 ENSG00000105717 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX4 protein_coding retained_intron 3.094115 4.020099 2.480953 0.5603715 0.3527244 -0.6941175 0.7726433 0.9492396 0.6229271 0.24001893 0.14269058 -0.5998518 0.25815000 0.22860000 0.24646667 0.017866667 0.948543338 0.001700598 FALSE FALSE
ENST00000559735 ENSG00000105717 HEK293_OSMI2_2hA HEK293_TMG_2hB PBX4 protein_coding retained_intron 3.094115 4.020099 2.480953 0.5603715 0.3527244 -0.6941175 0.1919479 0.1019273 0.1187982 0.01651006 0.04575691 0.2025499 0.06463750 0.02756667 0.04526667 0.017700000 0.502213816 0.001700598   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105717 E001 0.000000       19 19561707 19561712 6 -      
ENSG00000105717 E002 29.256654 0.0010272008 0.016875271 0.044656743 19 19561713 19562117 405 - 1.311 1.471 0.556
ENSG00000105717 E003 19.073856 0.0055525312 0.114274315 0.211772566 19 19563509 19563615 107 - 1.145 1.287 0.502
ENSG00000105717 E004 7.571316 0.0040416577 0.025835514 0.063601593 19 19563616 19563824 209 - 1.067 0.812 -0.959
ENSG00000105717 E005 8.219847 0.0020815379 0.005889078 0.018319975 19 19564775 19564932 158 - 1.115 0.812 -1.134
ENSG00000105717 E006 26.121224 0.0007808878 0.382601129 0.526805457 19 19564933 19565089 157 - 1.349 1.406 0.199
ENSG00000105717 E007 20.614985 0.0013199644 0.663818147 0.771799419 19 19569449 19569584 136 - 1.270 1.301 0.108
ENSG00000105717 E008 1.696148 0.0089114758 0.659343034 0.768174133 19 19570099 19570108 10 - 0.455 0.375 -0.434
ENSG00000105717 E009 17.120265 0.0012031437 0.479668924 0.618020866 19 19570109 19570225 117 - 1.173 1.231 0.204
ENSG00000105717 E010 15.830178 0.0015511515 0.747579213 0.835047960 19 19570226 19570299 74 - 1.212 1.181 -0.110
ENSG00000105717 E011 2.242295 0.0072484172 0.201819570 0.328460466 19 19570300 19570585 286 - 0.628 0.415 -1.020
ENSG00000105717 E012 11.683801 0.0028333664 0.036081628 0.083742388 19 19570586 19570686 101 - 0.900 1.125 0.827
ENSG00000105717 E013 20.928634 0.0010931369 0.715872618 0.811677339 19 19570687 19570833 147 - 1.311 1.280 -0.106
ENSG00000105717 E014 0.481513 0.0225889393 1.000000000 1.000000000 19 19570834 19570871 38 - 0.165 0.163 -0.021
ENSG00000105717 E015 0.147249 0.0419214172 0.246251814   19 19579832 19579954 123 - 0.165 0.000 -10.380
ENSG00000105717 E016 10.230735 0.0381780072 0.380398814 0.524692126 19 19599292 19599365 74 - 1.067 0.971 -0.349
ENSG00000105717 E017 9.665533 0.0025021141 0.001233066 0.004753004 19 19618511 19618693 183 - 1.199 0.869 -1.213