ENSG00000105711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262631 ENSG00000105711 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN1B protein_coding protein_coding 1.529602 2.479902 1.134152 0.2039363 0.03321317 -1.121811 0.83448950 1.6712687 0.41559788 0.14780559 0.21914745 -1.98198744 0.523304167 0.68193333 0.35610000 -0.32583333 4.848272e-01 4.858527e-07 FALSE TRUE
ENST00000415950 ENSG00000105711 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN1B protein_coding protein_coding 1.529602 2.479902 1.134152 0.2039363 0.03321317 -1.121811 0.17484657 0.1417814 0.14612058 0.01602647 0.03749108 0.04066535 0.136466667 0.05733333 0.13096667 0.07363333 3.225206e-01 4.858527e-07 FALSE TRUE
ENST00000595652 ENSG00000105711 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN1B protein_coding protein_coding 1.529602 2.479902 1.134152 0.2039363 0.03321317 -1.121811 0.02464975 0.1971980 0.00000000 0.19719800 0.00000000 -4.37293819 0.008695833 0.06956667 0.00000000 -0.06956667 8.931327e-01 4.858527e-07 FALSE TRUE
ENST00000596348 ENSG00000105711 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN1B protein_coding protein_coding 1.529602 2.479902 1.134152 0.2039363 0.03321317 -1.121811 0.10975184 0.0000000 0.38810669 0.00000000 0.10153225 5.31508321 0.079616667 0.00000000 0.34780000 0.34780000 4.858527e-07 4.858527e-07 FALSE TRUE
ENST00000602150 ENSG00000105711 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN1B protein_coding retained_intron 1.529602 2.479902 1.134152 0.2039363 0.03321317 -1.121811 0.17407905 0.1338025 0.07569023 0.02223343 0.04325773 -0.74688642 0.114666667 0.05523333 0.06806667 0.01283333 9.629556e-01 4.858527e-07 TRUE TRUE
ENST00000639260 ENSG00000105711 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN1B protein_coding retained_intron 1.529602 2.479902 1.134152 0.2039363 0.03321317 -1.121811 0.16740604 0.3358518 0.10863638 0.04938863 0.05939834 -1.54360729 0.111029167 0.13596667 0.09706667 -0.03890000 7.660192e-01 4.858527e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105711 E001 1.0601129 0.403065446 0.600260589 0.72152908 19 35030470 35030625 156 + 0.388 0.227 -1.068
ENSG00000105711 E002 1.4610869 0.106320984 0.201057692 0.32749623 19 35030626 35030732 107 + 0.533 0.274 -1.456
ENSG00000105711 E003 5.1113970 0.003615506 0.577809558 0.70299650 19 35030733 35030860 128 + 0.687 0.765 0.317
ENSG00000105711 E004 0.0000000       19 35031301 35031352 52 +      
ENSG00000105711 E005 0.8889184 0.013672579 0.008991070 0.02625761 19 35031353 35031780 428 + 0.534 0.086 -3.466
ENSG00000105711 E006 0.7665583 0.146318119 0.207760791 0.33578456 19 35032317 35032527 211 + 0.000 0.276 10.229
ENSG00000105711 E007 13.9170011 0.008591812 0.884642623 0.93026017 19 35032528 35032694 167 + 1.117 1.130 0.047
ENSG00000105711 E008 25.7359039 0.001001953 0.210863642 0.33956847 19 35033499 35033711 213 + 1.441 1.356 -0.295
ENSG00000105711 E009 10.6332061 0.001742998 0.841615035 0.90120125 19 35033712 35033739 28 + 1.008 1.027 0.069
ENSG00000105711 E010 9.5588938 0.019468663 0.005283629 0.01670395 19 35033740 35035887 2148 + 1.191 0.866 -1.195
ENSG00000105711 E011 1.1093169 0.015521183 0.920184705 0.95358650 19 35035888 35036013 126 + 0.294 0.274 -0.139
ENSG00000105711 E012 4.3447990 0.017972013 0.948623634 0.97179420 19 35036014 35036898 885 + 0.687 0.675 -0.050
ENSG00000105711 E013 2.1486023 0.208507377 0.738382632 0.82827201 19 35036899 35037162 264 + 0.390 0.478 0.466
ENSG00000105711 E014 2.1893012 0.048411107 0.965412563 0.98225293 19 35037163 35037354 192 + 0.468 0.472 0.022
ENSG00000105711 E015 4.1234686 0.005049740 0.289211085 0.42987856 19 35037355 35037855 501 + 0.766 0.610 -0.655
ENSG00000105711 E016 12.4621638 0.023241732 0.306370424 0.44853319 19 35037856 35039116 1261 + 0.987 1.109 0.447
ENSG00000105711 E017 20.2304352 0.001098820 0.793711846 0.86813579 19 35039117 35039258 142 + 1.265 1.283 0.063
ENSG00000105711 E018 2.0022122 0.201280986 0.603814367 0.72450152 19 35039259 35039634 376 + 0.535 0.428 -0.531
ENSG00000105711 E019 17.0462190 0.001153357 0.361116711 0.50550096 19 35039635 35039706 72 + 1.148 1.225 0.273
ENSG00000105711 E020 0.0000000       19 35039707 35039796 90 +      
ENSG00000105711 E021 30.8777638 0.001358104 0.014421398 0.03918099 19 35039797 35040449 653 + 1.329 1.489 0.554