ENSG00000105705

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247001 ENSG00000105705 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP1 protein_coding protein_coding 51.81064 71.84257 39.73522 1.480956 2.311416 -0.8542584 2.897857 7.493068 2.037865 0.2822861 1.4073325 -1.87336025 0.05247083 0.10436667 0.05593333 -0.04843333 0.599803785 0.006646339 FALSE TRUE
ENST00000586387 ENSG00000105705 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP1 protein_coding retained_intron 51.81064 71.84257 39.73522 1.480956 2.311416 -0.8542584 5.091560 4.891959 3.626287 0.1994404 0.2776500 -0.43089216 0.09977917 0.06806667 0.09203333 0.02396667 0.211232608 0.006646339 FALSE FALSE
ENST00000587716 ENSG00000105705 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP1 protein_coding processed_transcript 51.81064 71.84257 39.73522 1.480956 2.311416 -0.8542584 3.358000 1.721623 4.631886 1.7216229 0.4575532 1.42258622 0.07076667 0.02380000 0.11613333 0.09233333 0.084833951 0.006646339 FALSE TRUE
ENST00000588580 ENSG00000105705 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP1 protein_coding retained_intron 51.81064 71.84257 39.73522 1.480956 2.311416 -0.8542584 5.573045 4.444566 4.680405 1.5445517 0.6794543 0.07442762 0.11544583 0.06130000 0.11653333 0.05523333 0.281150090 0.006646339 FALSE TRUE
ENST00000588731 ENSG00000105705 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP1 protein_coding nonsense_mediated_decay 51.81064 71.84257 39.73522 1.480956 2.311416 -0.8542584 10.383614 12.784740 8.803733 0.2760660 0.2763035 -0.53772575 0.20812083 0.17816667 0.22256667 0.04440000 0.082882183 0.006646339 FALSE TRUE
ENST00000590439 ENSG00000105705 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP1 protein_coding protein_coding 51.81064 71.84257 39.73522 1.480956 2.311416 -0.8542584 4.999160 9.508180 3.952015 1.2243313 0.4010672 -1.26445131 0.09114583 0.13260000 0.09953333 -0.03306667 0.464659178 0.006646339 FALSE FALSE
ENST00000591007 ENSG00000105705 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP1 protein_coding retained_intron 51.81064 71.84257 39.73522 1.480956 2.311416 -0.8542584 15.927606 27.098130 8.954027 1.5374699 1.5566632 -1.59650676 0.28979167 0.37673333 0.22236667 -0.15436667 0.006646339 0.006646339 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105705 E001 0.0000000       19 19276018 19276032 15 -      
ENSG00000105705 E002 3.5792081 0.0050550354 9.351586e-02 1.806182e-01 19 19276033 19276217 185 - 0.395 0.686 1.377
ENSG00000105705 E003 13.1848316 0.0125165448 7.387241e-01 8.285325e-01 19 19276218 19276512 295 - 1.074 1.113 0.139
ENSG00000105705 E004 6.3345386 0.0030414643 9.485486e-01 9.717541e-01 19 19276513 19276513 1 - 0.809 0.818 0.035
ENSG00000105705 E005 6.8463292 0.0240266092 8.032768e-01 8.747609e-01 19 19276514 19276514 1 - 0.871 0.833 -0.147
ENSG00000105705 E006 198.2247972 0.0016842813 9.156334e-03 2.667282e-02 19 19276515 19276674 160 - 2.178 2.268 0.300
ENSG00000105705 E007 289.1119159 0.0002706805 2.782085e-05 1.667271e-04 19 19276947 19277076 130 - 2.333 2.435 0.342
ENSG00000105705 E008 356.1888139 0.0013863216 8.551869e-04 3.456121e-03 19 19277734 19277879 146 - 2.432 2.524 0.305
ENSG00000105705 E009 331.6195564 0.0030288882 2.600196e-03 9.065133e-03 19 19278690 19278796 107 - 2.392 2.494 0.342
ENSG00000105705 E010 421.0350216 0.0027309436 1.752140e-03 6.447145e-03 19 19279213 19279390 178 - 2.500 2.595 0.315
ENSG00000105705 E011 307.7938492 0.0001848870 2.880210e-03 9.911848e-03 19 19280185 19280291 107 - 2.385 2.454 0.229
ENSG00000105705 E012 4.3604149 0.0726354869 8.083662e-02 1.608505e-01 19 19280292 19281492 1201 - 0.395 0.766 1.704
ENSG00000105705 E013 373.5015194 0.0006592348 4.550178e-02 1.011129e-01 19 19296989 19297170 182 - 2.487 2.533 0.152
ENSG00000105705 E014 158.4563981 0.0011079864 1.801445e-02 4.716461e-02 19 19297171 19297181 11 - 2.088 2.172 0.280
ENSG00000105705 E015 336.8710547 0.0009150702 1.751918e-01 2.949297e-01 19 19297182 19297344 163 - 2.452 2.486 0.113
ENSG00000105705 E016 4.1404100 0.0073820328 9.664228e-03 2.793840e-02 19 19301659 19302018 360 - 0.899 0.526 -1.553
ENSG00000105705 E017 230.3854557 0.0002102100 8.417562e-01 9.013066e-01 19 19302265 19302329 65 - 2.317 2.313 -0.016
ENSG00000105705 E018 235.9289652 0.0001875354 2.913171e-01 4.321680e-01 19 19302330 19302388 59 - 2.341 2.315 -0.088
ENSG00000105705 E019 19.2657693 0.0186763389 1.807080e-01 3.020787e-01 19 19302389 19302443 55 - 1.357 1.218 -0.489
ENSG00000105705 E020 11.5590234 0.0017589547 3.285262e-01 4.720243e-01 19 19302444 19302455 12 - 1.126 1.027 -0.360
ENSG00000105705 E021 153.0070786 0.0003227238 8.804727e-01 9.273371e-01 19 19303348 19303350 3 - 2.140 2.135 -0.015
ENSG00000105705 E022 231.8436796 0.0045219231 6.028557e-01 7.237455e-01 19 19303351 19303406 56 - 2.331 2.308 -0.079
ENSG00000105705 E023 186.1137980 0.0054562930 3.121772e-01 4.547106e-01 19 19303407 19303448 42 - 2.254 2.205 -0.162
ENSG00000105705 E024 39.0992144 0.0005906178 4.127204e-04 1.823131e-03 19 19303449 19303686 238 - 1.690 1.485 -0.698
ENSG00000105705 E025 128.7571091 0.0009061697 3.280616e-02 7.742171e-02 19 19303724 19303724 1 - 2.116 2.039 -0.258
ENSG00000105705 E026 267.7039601 0.0018787582 3.449346e-02 8.070200e-02 19 19303725 19303847 123 - 2.424 2.357 -0.223
ENSG00000105705 E027 35.1171333 0.0204741714 9.007950e-04 3.616600e-03 19 19303848 19303912 65 - 1.707 1.399 -1.052
ENSG00000105705 E028 40.7512230 0.0014846029 1.327971e-06 1.074211e-05 19 19303913 19304043 131 - 1.755 1.476 -0.951
ENSG00000105705 E029 20.4646157 0.0617267067 4.615846e-03 1.486390e-02 19 19305646 19305848 203 - 1.520 1.137 -1.340
ENSG00000105705 E030 236.9421326 0.0001849322 7.592169e-01 8.436203e-01 19 19305849 19306042 194 - 2.329 2.321 -0.025
ENSG00000105705 E031 106.0896718 0.0042803766 2.126838e-01 3.417150e-01 19 19306043 19306076 34 - 1.930 1.991 0.204
ENSG00000105705 E032 183.0441611 0.0009393811 2.165533e-01 3.462465e-01 19 19310097 19310200 104 - 2.239 2.200 -0.133
ENSG00000105705 E033 0.2214452 0.0391545581 1.000000e+00   19 19316247 19316421 175 - 0.001 0.085 7.138
ENSG00000105705 E034 247.7906965 0.0020532568 1.923892e-05 1.198028e-04 19 19316422 19316522 101 - 2.437 2.300 -0.458
ENSG00000105705 E035 196.0935999 0.0030673593 7.299187e-07 6.244622e-06 19 19316523 19316593 71 - 2.367 2.181 -0.621
ENSG00000105705 E036 146.0194828 0.0019335524 8.230545e-08 8.498676e-07 19 19320463 19320509 47 - 2.248 2.050 -0.663
ENSG00000105705 E037 0.9619818 0.0237939075 3.225036e-01 4.658016e-01 19 19321064 19321099 36 - 0.395 0.215 -1.208