ENSG00000105701

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222308 ENSG00000105701 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP8 protein_coding protein_coding 260.3667 522.6567 122.1637 14.49003 2.982597 -2.096958 74.84009 149.89787 33.49836 6.202195 1.433076 -2.1614829 0.28642917 0.2868333 0.2740000 -0.01283333 0.76099220 1.753487e-08 FALSE  
ENST00000608443 ENSG00000105701 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP8 protein_coding protein_coding 260.3667 522.6567 122.1637 14.49003 2.982597 -2.096958 159.47277 330.22279 69.17645 8.362130 3.268452 -2.2549221 0.59626250 0.6321667 0.5659333 -0.06623333 0.16207880 1.753487e-08 FALSE  
MSTRG.16731.7 ENSG00000105701 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP8 protein_coding   260.3667 522.6567 122.1637 14.49003 2.982597 -2.096958 12.26715 19.84881 11.74761 3.518187 2.246419 -0.7561848 0.06057083 0.0377000 0.0965000 0.05880000 0.01482609 1.753487e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105701 E001 0.0000000       19 18531751 18531751 1 -      
ENSG00000105701 E002 0.6265839 4.398069e-02 5.709069e-01 6.973212e-01 19 18531752 18531761 10 - 0.000 0.197 9.274
ENSG00000105701 E003 1.2865790 1.161032e-01 2.361787e-01 3.697563e-01 19 18531762 18531762 1 - 0.000 0.328 11.431
ENSG00000105701 E004 188.2892965 7.649378e-03 7.119530e-06 4.893776e-05 19 18531763 18531813 51 - 1.871 2.152 0.943
ENSG00000105701 E005 2743.8497259 9.166888e-04 4.445610e-05 2.536082e-04 19 18531814 18532104 291 - 3.216 3.290 0.246
ENSG00000105701 E006 1751.7247342 6.645391e-04 8.753618e-03 2.566862e-02 19 18532105 18532128 24 - 3.043 3.092 0.162
ENSG00000105701 E007 3012.4450578 8.795745e-04 4.798684e-02 1.056153e-01 19 18532129 18532255 127 - 3.290 3.326 0.120
ENSG00000105701 E008 3236.2355552 9.493826e-05 8.359454e-02 1.651724e-01 19 18532664 18532795 132 - 3.335 3.354 0.064
ENSG00000105701 E009 15.0867864 2.270317e-02 4.548372e-01 5.954229e-01 19 18532796 18532814 19 - 0.957 1.073 0.427
ENSG00000105701 E010 2732.9602128 1.832653e-04 8.429840e-02 1.662978e-01 19 18533270 18533347 78 - 3.259 3.281 0.075
ENSG00000105701 E011 3859.6276632 4.064628e-05 1.588612e-01 2.736328e-01 19 18537601 18537773 173 - 3.434 3.426 -0.029
ENSG00000105701 E012 30.1383341 1.664641e-03 1.893733e-06 1.481202e-05 19 18538076 18538215 140 - 1.624 1.273 -1.208
ENSG00000105701 E013 3474.2128541 1.108433e-03 6.897970e-02 1.416862e-01 19 18538216 18538375 160 - 3.405 3.378 -0.090
ENSG00000105701 E014 2246.6771239 5.636449e-05 2.456031e-04 1.156914e-03 19 18538376 18538433 58 - 3.223 3.187 -0.119
ENSG00000105701 E015 1002.8720236 1.271274e-04 5.247018e-03 1.660317e-02 19 18538434 18538436 3 - 2.878 2.836 -0.139
ENSG00000105701 E016 2081.9541249 7.488513e-05 1.824756e-01 3.043274e-01 19 18539371 18539418 48 - 3.170 3.158 -0.041
ENSG00000105701 E017 1618.1684196 7.271721e-05 1.263774e-01 2.290973e-01 19 18539419 18539431 13 - 3.064 3.048 -0.055
ENSG00000105701 E018 1766.0264643 1.826796e-04 3.641933e-01 5.085599e-01 19 18539432 18539459 28 - 3.096 3.088 -0.030
ENSG00000105701 E019 3464.8810208 7.171341e-05 3.343909e-01 4.781379e-01 19 18539551 18539720 170 - 3.370 3.381 0.037
ENSG00000105701 E020 3624.4175117 7.370624e-04 6.703766e-01 7.768348e-01 19 18541679 18541901 223 - 3.403 3.400 -0.009
ENSG00000105701 E021 1689.8086303 1.068912e-03 5.819684e-03 1.813626e-02 19 18541902 18541971 70 - 3.111 3.061 -0.166
ENSG00000105701 E022 1117.5067124 1.964791e-03 9.580986e-01 9.777390e-01 19 18541972 18541995 24 - 2.886 2.890 0.013
ENSG00000105701 E023 32.7826485 6.908869e-04 3.190011e-08 3.572371e-07 19 18541996 18542498 503 - 1.680 1.300 -1.308
ENSG00000105701 E024 24.5924677 6.123659e-03 1.161657e-02 3.262121e-02 19 18542888 18542972 85 - 1.437 1.210 -0.792
ENSG00000105701 E025 2.1121709 4.939012e-01 2.764612e-01 4.159301e-01 19 18543181 18543424 244 - 0.597 0.327 -1.391
ENSG00000105701 E026 2.6957787 7.366482e-03 7.173753e-01 8.127758e-01 19 18543425 18543481 57 - 0.505 0.437 -0.340
ENSG00000105701 E027 6.2999165 2.659020e-03 3.712427e-01 5.156710e-01 19 18543482 18543485 4 - 0.594 0.750 0.658
ENSG00000105701 E028 891.9705008 2.130254e-03 9.985825e-01 1.000000e+00 19 18543486 18543577 92 - 2.790 2.792 0.008
ENSG00000105701 E029 12.0515888 1.497050e-03 6.324146e-01 7.472840e-01 19 18543909 18544077 169 - 1.022 0.966 -0.210