ENSG00000105700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222307 ENSG00000105700 HEK293_OSMI2_2hA HEK293_TMG_2hB KXD1 protein_coding protein_coding 169.3113 309.9406 92.96126 13.57314 0.8739109 -1.737182 117.53075 234.51346 59.63615 7.341115 0.7329153 -1.975231 0.6652042 0.7576000 0.6414667 -0.1161333 1.543927e-05 1.844583e-12 FALSE TRUE
ENST00000539106 ENSG00000105700 HEK293_OSMI2_2hA HEK293_TMG_2hB KXD1 protein_coding protein_coding 169.3113 309.9406 92.96126 13.57314 0.8739109 -1.737182 22.79095 35.81059 11.97361 3.874739 0.6007751 -1.579727 0.1415125 0.1151667 0.1287667 0.0136000 6.711738e-01 1.844583e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105700 E001 98.130691 1.073838e-02 5.911636e-03 1.837823e-02 19 18557762 18557805 44 + 2.007 1.851 -0.525
ENSG00000105700 E002 203.177206 7.484271e-03 2.462084e-02 6.109800e-02 19 18557806 18557837 32 + 2.272 2.179 -0.313
ENSG00000105700 E003 286.191349 5.258893e-03 2.177057e-02 5.519997e-02 19 18557838 18557869 32 + 2.408 2.330 -0.260
ENSG00000105700 E004 291.998050 3.908528e-03 1.020407e-02 2.926856e-02 19 18557870 18557875 6 + 2.418 2.338 -0.266
ENSG00000105700 E005 311.761840 4.329133e-03 1.805783e-02 4.725606e-02 19 18557876 18557878 3 + 2.441 2.368 -0.244
ENSG00000105700 E006 445.008174 1.962178e-03 5.377468e-01 6.692673e-01 19 18557879 18557887 9 + 2.534 2.536 0.004
ENSG00000105700 E007 519.182334 2.670784e-03 3.149041e-01 4.576551e-01 19 18557888 18557891 4 + 2.611 2.601 -0.036
ENSG00000105700 E008 569.144645 1.781534e-03 1.489630e-01 2.602775e-01 19 18557892 18557897 6 + 2.658 2.639 -0.064
ENSG00000105700 E009 712.864515 2.477889e-03 8.415532e-01 9.011800e-01 19 18557898 18557914 17 + 2.718 2.745 0.090
ENSG00000105700 E010 10.438128 2.567377e-01 6.036153e-01 7.243740e-01 19 18557915 18557949 35 + 1.092 0.924 -0.619
ENSG00000105700 E011 27.225637 6.639583e-03 3.143851e-03 1.068846e-02 19 18558539 18558604 66 + 1.517 1.290 -0.787
ENSG00000105700 E012 33.419386 1.079463e-03 8.855189e-07 7.439419e-06 19 18558654 18558766 113 + 1.657 1.343 -1.077
ENSG00000105700 E013 37.229271 5.662832e-04 2.174982e-09 3.026840e-08 19 18558827 18559111 285 + 1.733 1.378 -1.216
ENSG00000105700 E014 14.134244 1.250617e-03 3.754715e-03 1.245285e-02 19 18559112 18559130 19 + 1.282 1.014 -0.960
ENSG00000105700 E015 12.269267 1.480835e-03 2.638006e-04 1.232125e-03 19 18559131 18559172 42 + 1.282 0.927 -1.282
ENSG00000105700 E016 25.175234 9.238876e-04 3.450342e-06 2.549264e-05 19 18559173 18559285 113 + 1.556 1.224 -1.151
ENSG00000105700 E017 36.852982 5.851981e-04 1.972740e-13 5.377249e-12 19 18559286 18559580 295 + 1.781 1.349 -1.476
ENSG00000105700 E018 38.974987 5.387060e-04 1.368173e-15 5.083276e-14 19 18559581 18560099 519 + 1.820 1.365 -1.551
ENSG00000105700 E019 44.734581 3.431282e-03 2.348812e-08 2.700749e-07 19 18560100 18560419 320 + 1.803 1.471 -1.128
ENSG00000105700 E020 59.260487 1.510740e-03 7.960377e-06 5.408562e-05 19 18560420 18560550 131 + 1.844 1.618 -0.763
ENSG00000105700 E021 32.254068 5.773620e-03 2.658301e-05 1.601193e-04 19 18561520 18561779 260 + 1.632 1.332 -1.033
ENSG00000105700 E022 41.006737 1.331449e-02 1.730338e-01 2.921347e-01 19 18561780 18562035 256 + 1.586 1.489 -0.329
ENSG00000105700 E023 1066.503442 1.026372e-03 7.362851e-01 8.268102e-01 19 18562036 18562090 55 + 2.904 2.917 0.043
ENSG00000105700 E024 1270.349890 5.400354e-04 4.718487e-01 6.109318e-01 19 18562091 18562157 67 + 2.984 2.992 0.024
ENSG00000105700 E025 1994.073620 7.143985e-05 3.006897e-01 4.424242e-01 19 18564869 18565021 153 + 3.180 3.187 0.022
ENSG00000105700 E026 17.761489 3.489383e-03 4.838807e-01 6.219072e-01 19 18565134 18565190 57 + 1.088 1.178 0.323
ENSG00000105700 E027 1216.077046 1.814954e-03 4.308855e-01 5.734939e-01 19 18567132 18567178 47 + 2.973 2.974 0.003
ENSG00000105700 E028 5.060946 7.033691e-02 5.006691e-01 6.368995e-01 19 18567179 18567318 140 + 0.778 0.674 -0.427
ENSG00000105700 E029 2679.862266 9.807914e-04 7.140353e-01 8.103603e-01 19 18568402 18568679 278 + 3.296 3.321 0.083
ENSG00000105700 E030 785.052738 2.840011e-03 2.378587e-04 1.124488e-03 19 18568680 18568689 10 + 2.674 2.805 0.434
ENSG00000105700 E031 1455.889125 2.002867e-03 5.196909e-05 2.915770e-04 19 18568690 18568829 140 + 2.955 3.070 0.383
ENSG00000105700 E032 2731.334317 1.427578e-03 7.626922e-05 4.103773e-04 19 18568830 18569387 558 + 3.249 3.340 0.302