ENSG00000105699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354900 ENSG00000105699 HEK293_OSMI2_2hA HEK293_TMG_2hB LSR protein_coding protein_coding 62.1791 92.24872 54.21978 4.709601 3.659297 -0.7666001 14.415682 28.343229 7.667293 0.6499368 0.8331697 -1.88484338 0.2178583 0.30946667 0.14430000 -0.16516667 0.002363230 0.00236323 FALSE TRUE
ENST00000601623 ENSG00000105699 HEK293_OSMI2_2hA HEK293_TMG_2hB LSR protein_coding protein_coding 62.1791 92.24872 54.21978 4.709601 3.659297 -0.7666001 15.145706 16.246979 17.000613 2.6553733 2.3082350 0.06537601 0.2622542 0.17416667 0.31073333 0.13656667 0.004692558 0.00236323 FALSE FALSE
ENST00000605618 ENSG00000105699 HEK293_OSMI2_2hA HEK293_TMG_2hB LSR protein_coding protein_coding 62.1791 92.24872 54.21978 4.709601 3.659297 -0.7666001 13.913914 19.771172 12.728063 1.1940266 0.8610322 -0.63498198 0.2203542 0.21486667 0.23520000 0.02033333 0.697255182 0.00236323 FALSE TRUE
MSTRG.16968.11 ENSG00000105699 HEK293_OSMI2_2hA HEK293_TMG_2hB LSR protein_coding   62.1791 92.24872 54.21978 4.709601 3.659297 -0.7666001 7.243749 12.889149 5.368767 1.9925242 0.4973385 -1.26192850 0.1106708 0.13846667 0.09883333 -0.03963333 0.171854815 0.00236323 FALSE TRUE
MSTRG.16968.13 ENSG00000105699 HEK293_OSMI2_2hA HEK293_TMG_2hB LSR protein_coding   62.1791 92.24872 54.21978 4.709601 3.659297 -0.7666001 3.405784 4.440456 4.343378 0.8815870 1.3694075 -0.03181761 0.0562875 0.04743333 0.07913333 0.03170000 0.582148937 0.00236323 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105699 E001 1.870466 0.0948846456 3.853648e-01 5.295508e-01 19 35248330 35248391 62 + 0.543 0.359 -0.953
ENSG00000105699 E002 1.287802 0.0101231894 6.159370e-02 1.293107e-01 19 35248392 35248405 14 + 0.543 0.214 -1.968
ENSG00000105699 E003 3.418434 0.0054432214 1.673765e-01 2.847890e-01 19 35248406 35248502 97 + 0.739 0.524 -0.940
ENSG00000105699 E004 4.930727 0.0034969255 1.301659e-01 2.343974e-01 19 35248503 35248655 153 + 0.874 0.664 -0.845
ENSG00000105699 E005 6.891311 0.0084793014 2.347464e-02 5.873217e-02 19 35248656 35248719 64 + 1.040 0.754 -1.094
ENSG00000105699 E006 8.181314 0.0320050713 1.185905e-01 2.179299e-01 19 35248720 35248735 16 + 1.060 0.843 -0.813
ENSG00000105699 E007 15.668891 0.0015482251 4.259945e-02 9.581653e-02 19 35248736 35248764 29 + 1.300 1.117 -0.647
ENSG00000105699 E008 19.674261 0.0055552142 1.057900e-03 4.159474e-03 19 35248765 35248771 7 + 1.454 1.176 -0.972
ENSG00000105699 E009 36.696542 0.0148585051 2.827776e-03 9.757103e-03 19 35248772 35248878 107 + 1.693 1.446 -0.844
ENSG00000105699 E010 35.919494 0.0089609453 2.052757e-02 5.259944e-02 19 35248879 35248976 98 + 1.637 1.462 -0.601
ENSG00000105699 E011 19.966621 0.0408806298 2.844250e-01 4.246671e-01 19 35248977 35249001 25 + 1.351 1.226 -0.437
ENSG00000105699 E012 179.512477 0.0057955172 4.633205e-01 6.031202e-01 19 35249002 35249030 29 + 2.222 2.187 -0.115
ENSG00000105699 E013 273.397859 0.0022046403 1.075801e-02 3.058561e-02 19 35249031 35249100 70 + 2.439 2.356 -0.278
ENSG00000105699 E014 212.726598 0.0005141606 3.494398e-03 1.170920e-02 19 35249101 35249131 31 + 2.331 2.247 -0.283
ENSG00000105699 E015 0.294498 0.2888477768 9.244121e-02   19 35249347 35249368 22 + 0.300 0.000 -11.449
ENSG00000105699 E016 195.551528 0.0013992329 6.481818e-02 1.347438e-01 19 35250315 35250324 10 + 2.279 2.216 -0.210
ENSG00000105699 E017 820.092554 0.0020403626 1.812110e-05 1.135360e-04 19 35250325 35250562 238 + 2.929 2.827 -0.338
ENSG00000105699 E018 557.547641 0.0021347286 3.809092e-03 1.260562e-02 19 35250563 35250659 97 + 2.745 2.667 -0.261
ENSG00000105699 E019 536.713675 0.0003080009 2.074903e-01 3.354877e-01 19 35258945 35259064 120 + 2.692 2.666 -0.085
ENSG00000105699 E020 5.161808 0.0277392691 7.917122e-01 8.667743e-01 19 35259240 35259401 162 + 0.698 0.740 0.173
ENSG00000105699 E021 19.692586 0.0350559186 4.478549e-01 5.892096e-01 19 35260999 35261206 208 + 1.189 1.277 0.313
ENSG00000105699 E022 43.468312 0.0005659182 1.087070e-03 4.259756e-03 19 35261925 35261981 57 + 1.719 1.533 -0.632
ENSG00000105699 E023 424.335845 0.0002443043 9.818197e-02 1.877602e-01 19 35262546 35262692 147 + 2.549 2.579 0.100
ENSG00000105699 E024 7.189882 0.0028288994 7.659566e-01 8.485958e-01 19 35262693 35262723 31 + 0.844 0.880 0.136
ENSG00000105699 E025 515.830851 0.0002114013 3.552991e-02 8.267155e-02 19 35266359 35266495 137 + 2.628 2.663 0.116
ENSG00000105699 E026 340.756911 0.0007056258 2.483423e-01 3.839752e-01 19 35266496 35266532 37 + 2.458 2.483 0.083
ENSG00000105699 E027 7.451248 0.0022056803 4.456159e-02 9.939202e-02 19 35266533 35266678 146 + 1.040 0.800 -0.910
ENSG00000105699 E028 451.743388 0.0002393104 4.421387e-02 9.878393e-02 19 35266679 35266738 60 + 2.572 2.608 0.120
ENSG00000105699 E029 6.568599 0.0087565196 1.122886e-01 2.088859e-01 19 35266739 35266835 97 + 0.977 0.769 -0.797
ENSG00000105699 E030 218.188036 0.0012782132 8.910173e-02 1.737614e-01 19 35266836 35266838 3 + 2.247 2.298 0.172
ENSG00000105699 E031 543.250669 0.0001419516 2.140747e-01 3.433354e-01 19 35266839 35266967 129 + 2.664 2.683 0.060
ENSG00000105699 E032 1354.926751 0.0011985960 3.995120e-08 4.394748e-07 19 35267109 35267734 626 + 3.004 3.098 0.313
ENSG00000105699 E033 3.517521 0.0380900555 9.769085e-01 9.895860e-01 19 35267735 35267823 89 + 0.601 0.602 0.005
ENSG00000105699 E034 283.840525 0.0010051592 2.619026e-10 4.297434e-09 19 35267824 35268219 396 + 2.259 2.439 0.602