ENSG00000105671

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247003 ENSG00000105671 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX49 protein_coding protein_coding 98.4217 173.348 53.68873 5.549667 0.6643373 -1.690795 74.822544 135.032127 35.562862 3.6716527 0.6863122 -1.9245606 0.74865833 0.77946667 0.66250000 -0.11696667 0.0005307803 0.0005307803 FALSE TRUE
ENST00000599156 ENSG00000105671 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX49 protein_coding processed_transcript 98.4217 173.348 53.68873 5.549667 0.6643373 -1.690795 1.095150 2.246341 3.763162 2.2463407 0.5186611 0.7417893 0.01612083 0.01243333 0.07010000 0.05766667 0.0770804972 0.0005307803 FALSE FALSE
ENST00000601772 ENSG00000105671 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX49 protein_coding processed_transcript 98.4217 173.348 53.68873 5.549667 0.6643373 -1.690795 6.822961 11.310343 2.816529 0.7675109 1.3418653 -2.0018141 0.06731250 0.06546667 0.05230000 -0.01316667 0.7203155270 0.0005307803 FALSE FALSE
MSTRG.16751.1 ENSG00000105671 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX49 protein_coding   98.4217 173.348 53.68873 5.549667 0.6643373 -1.690795 5.438178 9.486291 3.334745 0.9791517 0.2169757 -1.5054682 0.05421667 0.05446667 0.06206667 0.00760000 0.6571781351 0.0005307803 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105671 E001 0.8836184 1.892402e-02 3.368341e-01 4.806983e-01 19 18919653 18919660 8 + 0.352 0.179 -1.295
ENSG00000105671 E002 16.4065956 1.188449e-03 9.354353e-02 1.806588e-01 19 18919661 18919704 44 + 1.252 1.104 -0.529
ENSG00000105671 E003 48.9242570 5.064767e-04 2.256421e-02 5.685301e-02 19 18919705 18919714 10 + 1.680 1.558 -0.417
ENSG00000105671 E004 149.1904274 6.893657e-04 4.869389e-01 6.246596e-01 19 18919715 18919726 12 + 2.071 2.059 -0.043
ENSG00000105671 E005 179.5203093 1.940796e-03 3.709686e-01 5.153809e-01 19 18919727 18919727 1 + 2.159 2.138 -0.069
ENSG00000105671 E006 182.7817521 1.753062e-03 4.010315e-01 5.447039e-01 19 18919728 18919728 1 + 2.164 2.146 -0.060
ENSG00000105671 E007 220.4440858 1.745851e-03 6.796956e-01 7.838030e-01 19 18919729 18919737 9 + 2.231 2.231 -0.002
ENSG00000105671 E008 783.6627699 1.356138e-03 9.586112e-02 1.841827e-01 19 18919738 18919856 119 + 2.801 2.777 -0.078
ENSG00000105671 E009 757.4297405 1.966123e-03 1.132223e-01 2.102279e-01 19 18920580 18920650 71 + 2.789 2.763 -0.086
ENSG00000105671 E010 666.0773238 1.796813e-03 1.074496e-01 2.017791e-01 19 18920651 18920703 53 + 2.735 2.707 -0.092
ENSG00000105671 E011 5.1553686 3.059423e-03 2.745580e-03 9.508820e-03 19 18920834 18920844 11 + 0.989 0.589 -1.602
ENSG00000105671 E012 7.7340898 2.307721e-03 1.940822e-03 7.043059e-03 19 18920845 18920909 65 + 1.110 0.746 -1.375
ENSG00000105671 E013 787.4642872 2.562635e-03 1.241767e-01 2.259424e-01 19 18921663 18921746 84 + 2.808 2.779 -0.097
ENSG00000105671 E014 413.7546681 4.897758e-04 5.187364e-02 1.124998e-01 19 18921747 18921748 2 + 2.530 2.497 -0.108
ENSG00000105671 E015 6.6468579 3.208887e-02 2.247400e-01 3.561203e-01 19 18921749 18921842 94 + 0.930 0.757 -0.672
ENSG00000105671 E016 898.5946912 6.463472e-04 9.132557e-02 1.772008e-01 19 18921843 18921964 122 + 2.854 2.837 -0.057
ENSG00000105671 E017 4.9180367 3.706164e-03 6.965280e-01 7.968547e-01 19 18921965 18922325 361 + 0.615 0.690 0.320
ENSG00000105671 E018 411.2812900 6.012742e-04 1.677962e-01 2.853288e-01 19 18922326 18922331 6 + 2.517 2.497 -0.065
ENSG00000105671 E019 1172.0936260 7.808759e-05 6.829839e-01 7.863027e-01 19 18922332 18922513 182 + 2.940 2.959 0.064
ENSG00000105671 E020 889.6040743 1.006998e-03 1.944398e-01 3.193276e-01 19 18922604 18922697 94 + 2.803 2.845 0.140
ENSG00000105671 E021 554.3176661 1.519231e-03 1.665598e-01 2.837205e-01 19 18922698 18922709 12 + 2.651 2.630 -0.071
ENSG00000105671 E022 670.0227478 7.763964e-04 3.367142e-01 4.805851e-01 19 18922710 18922744 35 + 2.720 2.715 -0.019
ENSG00000105671 E023 891.5694664 1.039067e-04 1.730886e-01 2.921969e-01 19 18924233 18924308 76 + 2.843 2.837 -0.023
ENSG00000105671 E024 574.4259205 1.459138e-04 3.022354e-03 1.033251e-02 19 18924623 18924626 4 + 2.680 2.638 -0.139
ENSG00000105671 E025 764.5662016 2.215197e-04 9.840121e-02 1.880857e-01 19 18924627 18924652 26 + 2.783 2.769 -0.047
ENSG00000105671 E026 905.8248992 8.392903e-05 2.247664e-03 7.991390e-03 19 18924653 18924699 47 + 2.870 2.839 -0.104
ENSG00000105671 E027 38.2277634 7.638392e-04 2.576929e-12 5.918189e-11 19 18924700 18924852 153 + 1.781 1.369 -1.407
ENSG00000105671 E028 23.9453123 8.090030e-04 1.312570e-07 1.303672e-06 19 18924853 18924881 29 + 1.571 1.188 -1.331
ENSG00000105671 E029 1193.2013081 6.968752e-04 8.907199e-01 9.342189e-01 19 18924882 18924979 98 + 2.949 2.967 0.058
ENSG00000105671 E030 111.4969747 6.043135e-03 2.560517e-01 3.930021e-01 19 18924980 18925129 150 + 1.870 1.951 0.273
ENSG00000105671 E031 94.9253538 1.268476e-03 9.467640e-01 9.705787e-01 19 18925130 18925188 59 + 1.859 1.869 0.035
ENSG00000105671 E032 1078.2242957 1.809270e-03 9.043045e-01 9.430823e-01 19 18926303 18926377 75 + 2.906 2.924 0.062
ENSG00000105671 E033 5.8258606 3.239908e-03 1.723762e-03 6.357419e-03 19 18927744 18927765 22 + 1.041 0.642 -1.562
ENSG00000105671 E034 1296.7629229 1.238190e-03 2.374987e-01 3.712566e-01 19 18927766 18927854 89 + 2.968 3.008 0.134
ENSG00000105671 E035 1323.2721805 2.490644e-03 5.008576e-02 1.093119e-01 19 18927965 18928036 72 + 2.954 3.022 0.227
ENSG00000105671 E036 2271.2258556 1.674738e-03 8.036793e-11 1.440986e-09 19 18928128 18929189 1062 + 3.118 3.269 0.503