ENSG00000105618

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321030 ENSG00000105618 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF31 protein_coding protein_coding 116.9136 181.659 79.8875 4.102071 1.178182 -1.18509 73.995298 127.22344 46.597831 3.2820727 0.3142343 -1.4488336 0.61261250 0.70040000 0.58346667 -0.11693333 1.862379e-06 1.46436e-09 FALSE TRUE
ENST00000419967 ENSG00000105618 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF31 protein_coding protein_coding 116.9136 181.659 79.8875 4.102071 1.178182 -1.18509 5.801169 4.67548 6.113584 0.3887376 0.5826190 0.3861795 0.05739167 0.02576667 0.07633333 0.05056667 1.464360e-09 1.46436e-09 FALSE TRUE
ENST00000445124 ENSG00000105618 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF31 protein_coding protein_coding 116.9136 181.659 79.8875 4.102071 1.178182 -1.18509 14.803995 13.77662 15.259677 7.3444832 0.7579200 0.1474008 0.14257917 0.07413333 0.19136667 0.11723333 6.444245e-01 1.46436e-09 FALSE TRUE
MSTRG.17669.6 ENSG00000105618 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF31 protein_coding   116.9136 181.659 79.8875 4.102071 1.178182 -1.18509 8.525804 18.77383 1.594845 5.0448266 0.7172181 -3.5489853 0.05947500 0.10466667 0.01980000 -0.08486667 2.153035e-02 1.46436e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105618 E001 27.702929 1.369782e-03 7.037399e-22 5.522842e-20 19 54114838 54115122 285 + 1.772 1.137 -2.197
ENSG00000105618 E002 46.580995 1.580629e-02 1.942913e-14 6.133628e-13 19 54115410 54115683 274 + 1.977 1.368 -2.074
ENSG00000105618 E003 34.360866 6.857265e-03 6.926738e-13 1.744781e-11 19 54115684 54115753 70 + 1.799 1.295 -1.726
ENSG00000105618 E004 81.603540 3.477551e-04 3.141744e-12 7.112738e-11 19 54115754 54115772 19 + 2.043 1.763 -0.944
ENSG00000105618 E005 110.086106 3.322517e-04 7.201283e-10 1.097909e-08 19 54115773 54115778 6 + 2.132 1.915 -0.727
ENSG00000105618 E006 368.375206 1.883457e-04 2.088244e-19 1.249958e-17 19 54115779 54115797 19 + 2.625 2.446 -0.596
ENSG00000105618 E007 2.028336 7.252716e-03 6.209207e-01 7.379647e-01 19 54115809 54115872 64 + 0.496 0.413 -0.429
ENSG00000105618 E008 54.525479 4.214169e-04 7.767993e-01 8.562836e-01 19 54118241 54118247 7 + 1.681 1.672 -0.030
ENSG00000105618 E009 79.396682 3.435153e-04 3.904097e-01 5.343763e-01 19 54118248 54118270 23 + 1.857 1.825 -0.109
ENSG00000105618 E010 1005.483913 3.992992e-04 1.283400e-10 2.224282e-09 19 54118271 54118405 135 + 2.999 2.908 -0.304
ENSG00000105618 E011 576.118989 1.594092e-03 3.391945e-03 1.141476e-02 19 54118406 54118408 3 + 2.741 2.673 -0.225
ENSG00000105618 E012 825.898605 9.537954e-04 6.150860e-04 2.588493e-03 19 54118409 54118455 47 + 2.893 2.831 -0.207
ENSG00000105618 E013 784.884379 5.346346e-04 1.241463e-01 2.258999e-01 19 54118573 54118612 40 + 2.840 2.819 -0.071
ENSG00000105618 E014 593.492744 1.778926e-03 2.546461e-01 3.913867e-01 19 54118613 54118633 21 + 2.721 2.697 -0.079
ENSG00000105618 E015 11.681722 2.059675e-03 4.115726e-02 9.317447e-02 19 54118634 54118811 178 + 0.837 1.090 0.944
ENSG00000105618 E016 980.324571 1.059335e-03 8.441951e-02 1.664750e-01 19 54121860 54121943 84 + 2.942 2.913 -0.095
ENSG00000105618 E017 965.017835 4.880967e-04 1.632032e-02 4.343259e-02 19 54122497 54122594 98 + 2.938 2.905 -0.110
ENSG00000105618 E018 963.074119 1.352326e-04 5.900479e-01 7.129940e-01 19 54123454 54123560 107 + 2.913 2.912 -0.004
ENSG00000105618 E019 1168.724350 7.880109e-05 2.811770e-01 4.210683e-01 19 54123749 54123918 170 + 2.982 3.002 0.065
ENSG00000105618 E020 1093.999527 1.567032e-03 4.861228e-02 1.067045e-01 19 54124499 54124656 158 + 2.930 2.979 0.164
ENSG00000105618 E021 7.926025 3.339597e-02 5.402372e-01 6.714076e-01 19 54126500 54126527 28 + 0.955 0.882 -0.273
ENSG00000105618 E022 800.185800 2.047794e-04 2.934474e-02 7.067202e-02 19 54126528 54126617 90 + 2.801 2.841 0.135
ENSG00000105618 E023 6.229047 6.283330e-03 4.613142e-01 6.012907e-01 19 54126618 54126631 14 + 0.870 0.775 -0.370
ENSG00000105618 E024 537.121445 2.879935e-04 3.613475e-01 5.057401e-01 19 54128073 54128090 18 + 2.640 2.664 0.078
ENSG00000105618 E025 983.025495 2.548827e-04 6.609170e-05 3.612590e-04 19 54128091 54128200 110 + 2.870 2.935 0.219
ENSG00000105618 E026 13.291079 2.727520e-02 2.647985e-05 1.595892e-04 19 54128201 54128304 104 + 1.399 0.905 -1.773
ENSG00000105618 E027 838.607713 1.045939e-04 1.684450e-07 1.638078e-06 19 54128305 54128377 73 + 2.787 2.872 0.281
ENSG00000105618 E028 986.547825 2.952568e-04 9.723305e-05 5.090789e-04 19 54129057 54129143 87 + 2.873 2.939 0.219
ENSG00000105618 E029 766.613245 1.372896e-03 3.950204e-05 2.280039e-04 19 54129144 54129185 42 + 2.734 2.837 0.341
ENSG00000105618 E030 59.915485 7.244339e-03 1.385640e-07 1.370428e-06 19 54129186 54129271 86 + 1.937 1.615 -1.087
ENSG00000105618 E031 970.203642 1.095425e-03 2.523596e-07 2.372173e-06 19 54129272 54129370 99 + 2.828 2.940 0.375
ENSG00000105618 E032 1416.542304 2.053795e-03 2.677474e-05 1.611717e-04 19 54131307 54131792 486 + 2.997 3.104 0.356