ENSG00000105613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251472 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding protein_coding 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 1.5573466 1.4729605 1.6060164 0.12843291 0.07047909 0.1239617 0.24147500 0.18353333 0.33956667 0.15603333 7.139011e-02 2.733547e-06 FALSE  
ENST00000588379 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding protein_coding 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 2.7764481 3.6981384 1.8347336 0.48307935 0.01809426 -1.0072826 0.38603750 0.44100000 0.38810000 -0.05290000 6.656082e-01 2.733547e-06 FALSE  
ENST00000589040 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding retained_intron 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 0.4317467 0.1255072 0.5439226 0.07435140 0.05427472 2.0313151 0.06995417 0.01383333 0.11340000 0.09956667 1.147735e-05 2.733547e-06 TRUE  
ENST00000590204 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding protein_coding 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 0.2324086 0.1013469 0.5553995 0.10134687 0.55539954 2.3442096 0.03502917 0.01530000 0.09243333 0.07713333 9.615012e-01 2.733547e-06 FALSE  
ENST00000590553 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding retained_intron 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 0.5030903 0.9311740 0.0000000 0.46824176 0.00000000 -6.5563896 0.06085833 0.10110000 0.00000000 -0.10110000 2.192033e-01 2.733547e-06 FALSE  
ENST00000590883 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding retained_intron 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 0.3701138 0.6643751 0.1719914 0.15014360 0.03530722 -1.8896811 0.05043333 0.07750000 0.03543333 -0.04206667 8.614727e-02 2.733547e-06 FALSE  
ENST00000591495 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding protein_coding 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 0.1971499 0.5057517 0.0000000 0.10627370 0.00000000 -5.6886046 0.03192083 0.06290000 0.00000000 -0.06290000 4.015758e-05 2.733547e-06 FALSE  
ENST00000592713 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding retained_intron 6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 0.3527190 0.1517035 0.1326501 0.07828259 0.06674788 -0.1808700 0.05823333 0.01980000 0.03110000 0.01130000 9.044851e-01 2.733547e-06    
MSTRG.16526.4 ENSG00000105613 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST1 protein_coding   6.897953 8.34563 4.844714 0.9202052 0.5828976 -0.7833625 0.4653554 0.6946731 0.0000000 0.16894329 0.00000000 -6.1388823 0.06477917 0.08506667 0.00000000 -0.08506667 2.733547e-06 2.733547e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105613 E001 0.8449086 0.0145854122 4.179356e-01 5.612539e-01 19 12833951 12834006 56 + 0.155 0.299 1.211
ENSG00000105613 E002 0.6997360 0.0168439693 1.113078e-01 2.074691e-01 19 12838269 12838300 32 + 0.000 0.299 11.712
ENSG00000105613 E003 2.5035669 0.2179363311 9.877507e-01 9.964096e-01 19 12838473 12838514 42 + 0.496 0.520 0.117
ENSG00000105613 E004 6.2112125 0.0359205949 9.150497e-01 9.502098e-01 19 12838515 12838540 26 + 0.816 0.829 0.050
ENSG00000105613 E005 17.6133586 0.0021724966 9.916689e-01 9.988818e-01 19 12838541 12838655 115 + 1.237 1.234 -0.011
ENSG00000105613 E006 20.0706490 0.0012750539 1.292111e-01 2.330857e-01 19 12840446 12840502 57 + 1.203 1.324 0.424
ENSG00000105613 E007 16.9522270 0.0031992489 2.876839e-01 4.282043e-01 19 12840503 12840534 32 + 1.154 1.246 0.327
ENSG00000105613 E008 25.6570203 0.0022041631 9.962513e-01 1.000000e+00 19 12840991 12841066 76 + 1.389 1.386 -0.011
ENSG00000105613 E009 30.1315089 0.0007086945 2.627094e-01 4.005079e-01 19 12843529 12843607 79 + 1.508 1.432 -0.263
ENSG00000105613 E010 0.8178402 0.0884849680 4.542637e-01 5.949211e-01 19 12847235 12847289 55 + 0.155 0.297 1.199
ENSG00000105613 E011 42.9154125 0.0005344774 8.611964e-01 9.144522e-01 19 12847290 12847450 161 + 1.601 1.607 0.018
ENSG00000105613 E012 32.3804583 0.0006781886 2.653015e-01 4.033398e-01 19 12847612 12847687 76 + 1.536 1.462 -0.252
ENSG00000105613 E013 2.1275015 0.0115542174 2.124019e-02 5.409399e-02 19 12847688 12847801 114 + 0.686 0.299 -1.955
ENSG00000105613 E014 1.5822997 0.0093291165 3.671130e-02 8.492291e-02 19 12847819 12847847 29 + 0.601 0.241 -2.010
ENSG00000105613 E015 62.2350291 0.0007057486 7.525424e-01 8.387047e-01 19 12847848 12848057 210 + 1.762 1.773 0.034
ENSG00000105613 E016 8.2758854 0.0021734538 3.154703e-04 1.442691e-03 19 12848058 12848979 922 + 0.552 1.038 1.950
ENSG00000105613 E017 45.3531704 0.0007248319 1.142675e-02 3.217927e-02 19 12851934 12852035 102 + 1.536 1.673 0.467
ENSG00000105613 E018 41.1928386 0.0007512936 4.441651e-04 1.944307e-03 19 12852115 12852185 71 + 1.446 1.652 0.703
ENSG00000105613 E019 36.4380582 0.0010611976 3.026482e-03 1.034419e-02 19 12852186 12852247 62 + 1.412 1.595 0.630
ENSG00000105613 E020 33.4816686 0.0006450803 5.297976e-03 1.674270e-02 19 12852328 12852395 68 + 1.374 1.553 0.614
ENSG00000105613 E021 1.5101892 0.0100436199 3.485650e-01 4.928029e-01 19 12858174 12858361 188 + 0.268 0.437 1.018
ENSG00000105613 E022 34.5714969 0.0007158474 7.913983e-02 1.581403e-01 19 12858362 12858441 80 + 1.440 1.547 0.367
ENSG00000105613 E023 44.9589239 0.0005158860 3.560617e-01 5.004549e-01 19 12858531 12858739 209 + 1.596 1.642 0.156
ENSG00000105613 E024 11.2536075 0.0016072894 6.715329e-02 1.386230e-01 19 12858740 12858741 2 + 0.917 1.110 0.710
ENSG00000105613 E025 18.2640239 0.0010963155 9.782838e-02 1.871993e-01 19 12858742 12858921 180 + 1.154 1.292 0.487
ENSG00000105613 E026 9.7080243 0.0287467418 9.939487e-06 6.610334e-05 19 12864809 12864947 139 + 1.306 0.735 -2.116
ENSG00000105613 E027 9.9766990 0.0019923543 2.167238e-08 2.510405e-07 19 12865046 12865178 133 + 1.315 0.737 -2.142
ENSG00000105613 E028 4.6909884 0.0149465808 1.132905e-05 7.433947e-05 19 12865179 12865315 137 + 1.035 0.397 -2.719
ENSG00000105613 E029 11.6843851 0.0019975500 2.975174e-06 2.227993e-05 19 12865316 12865481 166 + 1.324 0.872 -1.642
ENSG00000105613 E030 7.4598596 0.0023389851 1.160378e-03 4.506563e-03 19 12865717 12865818 102 + 1.113 0.737 -1.425
ENSG00000105613 E031 7.7358074 0.0055004813 2.367351e-03 8.359975e-03 19 12865980 12866102 123 + 1.113 0.757 -1.346
ENSG00000105613 E032 11.2130094 0.0294817184 4.173511e-02 9.425176e-02 19 12866653 12866762 110 + 1.204 0.955 -0.904
ENSG00000105613 E033 11.0152942 0.0126746447 1.675933e-01 2.850606e-01 19 12867474 12867652 179 + 1.141 0.987 -0.559
ENSG00000105613 E034 18.9205002 0.0010894250 9.395804e-01 9.660772e-01 19 12867730 12867977 248 + 1.268 1.258 -0.036
ENSG00000105613 E035 0.0000000       19 12868601 12868642 42 +      
ENSG00000105613 E036 26.7441414 0.0007626062 5.092405e-01 6.445743e-01 19 12868643 12868849 207 + 1.440 1.390 -0.171
ENSG00000105613 E037 34.2362573 0.0006144544 5.746843e-03 1.794646e-02 19 12869066 12869295 230 + 1.619 1.451 -0.576
ENSG00000105613 E038 25.3247206 0.0022299399 1.048996e-02 2.995434e-02 19 12870824 12870946 123 + 1.508 1.324 -0.638
ENSG00000105613 E039 27.0285149 0.0008076826 4.359611e-02 9.763746e-02 19 12871036 12871172 137 + 1.502 1.363 -0.481
ENSG00000105613 E040 0.1817044 0.0396256935 7.940489e-01   19 12873254 12873323 70 + 0.000 0.096 9.759
ENSG00000105613 E041 22.2687323 0.0009190926 2.224192e-02 5.617772e-02 19 12873324 12873511 188 + 1.203 1.381 0.623
ENSG00000105613 E042 73.2557561 0.0011623001 1.300264e-02 3.591775e-02 19 12873609 12874952 1344 + 1.759 1.868 0.366