ENSG00000105607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222214 ENSG00000105607 HEK293_OSMI2_2hA HEK293_TMG_2hB GCDH protein_coding protein_coding 44.0518 69.3784 27.74423 4.178107 0.3462772 -1.321987 18.831076 39.1880225 8.589220 1.4746674 0.6094114 -2.1885031 0.39231250 0.567966667 0.30966667 -0.2583000 1.648748e-05 1.061949e-06 FALSE TRUE
ENST00000585420 ENSG00000105607 HEK293_OSMI2_2hA HEK293_TMG_2hB GCDH protein_coding retained_intron 44.0518 69.3784 27.74423 4.178107 0.3462772 -1.321987 2.151267 2.1758666 1.683191 0.4223657 0.1989743 -0.3684609 0.05250417 0.030866667 0.06066667 0.0298000 2.661809e-02 1.061949e-06 FALSE TRUE
ENST00000587832 ENSG00000105607 HEK293_OSMI2_2hA HEK293_TMG_2hB GCDH protein_coding retained_intron 44.0518 69.3784 27.74423 4.178107 0.3462772 -1.321987 1.144695 0.5783033 2.020968 0.1372797 0.4911984 1.7875354 0.03132917 0.008266667 0.07306667 0.0648000 4.457667e-06 1.061949e-06 FALSE TRUE
ENST00000591470 ENSG00000105607 HEK293_OSMI2_2hA HEK293_TMG_2hB GCDH protein_coding protein_coding 44.0518 69.3784 27.74423 4.178107 0.3462772 -1.321987 2.355139 3.0797736 1.733057 0.5276329 0.1343741 -0.8258817 0.05566667 0.044366667 0.06256667 0.0182000 3.446077e-01 1.061949e-06 FALSE TRUE
MSTRG.16527.1 ENSG00000105607 HEK293_OSMI2_2hA HEK293_TMG_2hB GCDH protein_coding   44.0518 69.3784 27.74423 4.178107 0.3462772 -1.321987 7.257395 12.2196397 3.132105 1.8917052 0.4462053 -1.9605788 0.15386667 0.175100000 0.11320000 -0.0619000 2.494502e-01 1.061949e-06 FALSE TRUE
MSTRG.16527.14 ENSG00000105607 HEK293_OSMI2_2hA HEK293_TMG_2hB GCDH protein_coding   44.0518 69.3784 27.74423 4.178107 0.3462772 -1.321987 4.412686 5.2770669 5.972636 0.6390954 0.7512528 0.1783138 0.11243333 0.075600000 0.21463333 0.1390333 1.061949e-06 1.061949e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105607 E001 0.7717566 0.0516761119 8.599934e-01 9.136976e-01 19 12891021 12891028 8 + 0.198 0.238 0.335
ENSG00000105607 E002 0.7717566 0.0516761119 8.599934e-01 9.136976e-01 19 12891029 12891077 49 + 0.198 0.238 0.335
ENSG00000105607 E003 0.3697384 0.0274424043 7.679545e-01 8.500635e-01 19 12891078 12891138 61 + 0.000 0.136 8.860
ENSG00000105607 E004 0.6632043 0.0188998381 9.789388e-01 9.908692e-01 19 12891139 12891143 5 + 0.198 0.190 -0.070
ENSG00000105607 E005 1.6156211 0.0096260089 6.627170e-01 7.709717e-01 19 12891144 12891159 16 + 0.436 0.358 -0.433
ENSG00000105607 E006 1.6156211 0.0096260089 6.627170e-01 7.709717e-01 19 12891160 12891160 1 + 0.436 0.358 -0.433
ENSG00000105607 E007 1.9122075 0.0498661178 9.123649e-01 9.484408e-01 19 12891161 12891163 3 + 0.436 0.420 -0.084
ENSG00000105607 E008 1.9122075 0.0498661178 9.123649e-01 9.484408e-01 19 12891164 12891165 2 + 0.436 0.420 -0.084
ENSG00000105607 E009 1.9122075 0.0498661178 9.123649e-01 9.484408e-01 19 12891166 12891166 1 + 0.436 0.420 -0.084
ENSG00000105607 E010 2.5066133 0.0062200250 8.051231e-01 8.760247e-01 19 12891167 12891167 1 + 0.520 0.480 -0.195
ENSG00000105607 E011 22.8740148 0.0008310608 9.054743e-02 1.759920e-01 19 12891168 12891176 9 + 1.392 1.261 -0.457
ENSG00000105607 E012 26.1211622 0.0008115417 1.889001e-01 3.123744e-01 19 12891177 12891179 3 + 1.422 1.326 -0.332
ENSG00000105607 E013 130.0883753 0.0062182026 6.104804e-02 1.283999e-01 19 12891180 12891202 23 + 2.089 2.003 -0.289
ENSG00000105607 E014 14.2806613 0.0041809991 3.160983e-02 7.509330e-02 19 12891203 12891268 66 + 1.249 1.039 -0.753
ENSG00000105607 E015 13.5150323 0.0012921188 7.437612e-02 1.505377e-01 19 12891269 12891270 2 + 1.204 1.031 -0.625
ENSG00000105607 E016 280.0256305 0.0026818908 1.955509e-01 3.206500e-01 19 12891271 12891395 125 + 2.384 2.347 -0.124
ENSG00000105607 E017 233.6692525 0.0014952997 5.709799e-03 1.784337e-02 19 12891487 12891522 36 + 2.339 2.257 -0.273
ENSG00000105607 E018 16.9876178 0.0588374074 2.186455e-02 5.539738e-02 19 12891523 12891660 138 + 1.382 1.077 -1.079
ENSG00000105607 E019 19.6916302 0.0151117167 8.675368e-04 3.500133e-03 19 12891661 12891830 170 + 1.449 1.130 -1.121
ENSG00000105607 E020 424.6377429 0.0001712777 1.768769e-05 1.110195e-04 19 12891831 12891974 144 + 2.597 2.516 -0.268
ENSG00000105607 E021 330.2718841 0.0001738787 3.644952e-05 2.121364e-04 19 12892116 12892178 63 + 2.494 2.406 -0.293
ENSG00000105607 E022 2.6956926 0.0059204297 5.089726e-01 6.443472e-01 19 12892179 12892283 105 + 0.590 0.480 -0.516
ENSG00000105607 E023 2.3594671 0.0136052225 4.040726e-02 9.176718e-02 19 12892317 12892386 70 + 0.703 0.359 -1.651
ENSG00000105607 E024 2.0681913 0.1826034420 1.367670e-01 2.435823e-01 19 12892387 12892434 48 + 0.651 0.328 -1.620
ENSG00000105607 E025 497.2506859 0.0006381302 5.446673e-01 6.751024e-01 19 12893483 12893653 171 + 2.610 2.603 -0.024
ENSG00000105607 E026 8.1328574 0.0353785467 1.903181e-06 1.487794e-05 19 12893654 12893882 229 + 1.290 0.637 -2.473
ENSG00000105607 E027 468.0149254 0.0005761714 9.147377e-01 9.500233e-01 19 12895992 12896121 130 + 2.575 2.579 0.011
ENSG00000105607 E028 298.3626082 0.0008617461 2.260027e-02 5.692041e-02 19 12896205 12896239 35 + 2.428 2.373 -0.186
ENSG00000105607 E029 529.1040523 0.0001233948 6.691545e-01 7.760357e-01 19 12896240 12896421 182 + 2.621 2.634 0.043
ENSG00000105607 E030 391.7837078 0.0021791227 4.981939e-03 1.588002e-02 19 12896910 12897013 104 + 2.424 2.520 0.320
ENSG00000105607 E031 352.3919412 0.0002527148 2.221414e-03 7.910085e-03 19 12897303 12897379 77 + 2.390 2.469 0.262
ENSG00000105607 E032 262.4122599 0.0001702761 1.708122e-02 4.511909e-02 19 12897380 12897428 49 + 2.270 2.340 0.232
ENSG00000105607 E033 14.3083629 0.0033645849 1.014633e-04 5.286263e-04 19 12897429 12897702 274 + 1.349 0.984 -1.305
ENSG00000105607 E034 543.3630340 0.0007807052 1.543601e-03 5.776747e-03 19 12897703 12897863 161 + 2.583 2.660 0.254
ENSG00000105607 E035 11.6467212 0.0014733127 5.662923e-03 1.772157e-02 19 12898126 12898383 258 + 1.220 0.940 -1.016
ENSG00000105607 E036 420.6553713 0.0031219981 7.781024e-03 2.323014e-02 19 12899468 12899570 103 + 2.457 2.553 0.319
ENSG00000105607 E037 325.8770536 0.0010653399 6.423973e-08 6.773165e-07 19 12899571 12899699 129 + 2.289 2.453 0.549
ENSG00000105607 E038 207.3695293 0.0046195406 2.056856e-04 9.883710e-04 19 12899700 12900139 440 + 2.083 2.261 0.596
ENSG00000105607 E039 33.5355670 0.0013268858 4.248782e-04 1.869644e-03 19 12900234 12900318 85 + 1.623 1.395 -0.782
ENSG00000105607 E040 34.4362380 0.0007307421 2.599622e-04 1.216687e-03 19 12900319 12900670 352 + 1.635 1.405 -0.789
ENSG00000105607 E041 2.9829175 0.0051112368 6.003681e-02 1.266654e-01 19 12902399 12902533 135 + 0.750 0.453 -1.331
ENSG00000105607 E042 8.1492609 0.0576792035 1.751380e-02 4.607029e-02 19 12905954 12906023 70 + 1.138 0.775 -1.360
ENSG00000105607 E043 15.2668172 0.0012193958 7.666124e-03 2.294242e-02 19 12913995 12914469 475 + 1.302 1.059 -0.865