ENSG00000105568

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322088 ENSG00000105568 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R1A protein_coding protein_coding 288.9531 492.8467 150.573 27.06781 1.897458 -1.71061 49.07173 98.79197 19.92538 3.363021 0.5871343 -2.309209 0.1573333 0.2022667 0.1322667 -0.07000000 0.007381369 0.007381369 FALSE  
MSTRG.17613.3 ENSG00000105568 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R1A protein_coding   288.9531 492.8467 150.573 27.06781 1.897458 -1.71061 235.36186 388.22099 127.61395 28.809284 1.4491860 -1.605016 0.8253708 0.7860000 0.8475333 0.06153333 0.029839243 0.007381369 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105568 E001 0.7575771 1.094526e+00 1.058206e-01 1.993350e-01 19 52188981 52189156 176 + 0.631 0.000 -13.842
ENSG00000105568 E002 4.5222751 4.091402e-03 6.879446e-01 7.901699e-01 19 52189968 52189973 6 + 0.688 0.632 -0.240
ENSG00000105568 E003 196.7409048 1.364444e-03 1.520139e-02 4.094255e-02 19 52189974 52190047 74 + 2.234 2.159 -0.250
ENSG00000105568 E004 218.1609424 3.221679e-03 1.310794e-01 2.356503e-01 19 52190048 52190050 3 + 2.258 2.209 -0.162
ENSG00000105568 E005 223.6397859 2.960514e-03 1.342375e-01 2.400500e-01 19 52190051 52190051 1 + 2.267 2.221 -0.156
ENSG00000105568 E006 235.2565075 2.696342e-03 2.408756e-01 3.752018e-01 19 52190052 52190053 2 + 2.278 2.245 -0.109
ENSG00000105568 E007 907.9117515 2.409932e-03 1.200492e-06 9.803421e-06 19 52190054 52190090 37 + 2.934 2.813 -0.402
ENSG00000105568 E008 994.6891407 2.257426e-03 1.136478e-06 9.325057e-06 19 52190091 52190096 6 + 2.970 2.854 -0.386
ENSG00000105568 E009 1196.6311289 2.372645e-03 1.639912e-06 1.299792e-05 19 52190097 52190113 17 + 3.049 2.935 -0.378
ENSG00000105568 E010 1713.9833766 3.031990e-03 2.673404e-05 1.609517e-04 19 52190114 52190174 61 + 3.198 3.093 -0.347
ENSG00000105568 E011 1.2521237 1.434990e-01 6.765004e-01 7.814502e-01 19 52190175 52190294 120 + 0.216 0.325 0.788
ENSG00000105568 E012 1.5885406 9.590338e-02 6.326574e-02 1.321503e-01 19 52191045 52191404 360 + 0.626 0.259 -1.989
ENSG00000105568 E013 1.9408893 3.490421e-01 1.724326e-01 2.913678e-01 19 52200274 52200398 125 + 0.691 0.294 -2.014
ENSG00000105568 E014 0.3729606 3.100978e-02 3.107721e-01 4.532007e-01 19 52201093 52201180 88 + 0.216 0.066 -1.975
ENSG00000105568 E015 0.7321030 3.378368e-02 7.984042e-01 8.713364e-01 19 52201181 52201513 333 + 0.216 0.174 -0.388
ENSG00000105568 E016 0.6579068 4.725102e-01 3.088541e-01 4.511190e-01 19 52201514 52201694 181 + 0.360 0.124 -1.964
ENSG00000105568 E017 3.0152794 1.151459e-02 1.273011e-01 2.303772e-01 19 52201767 52201943 177 + 0.216 0.540 1.934
ENSG00000105568 E018 2213.7685542 2.680544e-03 2.797910e-04 1.297629e-03 19 52201944 52202034 91 + 3.290 3.209 -0.268
ENSG00000105568 E019 2416.7710019 1.631348e-03 1.711054e-03 6.316698e-03 19 52205963 52206063 101 + 3.304 3.253 -0.171
ENSG00000105568 E020 3584.6625342 2.863415e-03 1.729558e-02 4.559567e-02 19 52211260 52211492 233 + 3.471 3.425 -0.153
ENSG00000105568 E021 27.4656857 3.631717e-03 1.433294e-01 2.525351e-01 19 52211493 52211694 202 + 1.418 1.307 -0.386
ENSG00000105568 E022 6.8129297 2.563144e-03 2.158431e-01 3.454172e-01 19 52212492 52212685 194 + 0.909 0.748 -0.629
ENSG00000105568 E023 2595.5750341 1.848612e-03 5.386080e-02 1.160085e-01 19 52212686 52212829 144 + 3.316 3.288 -0.092
ENSG00000105568 E024 1124.7825244 2.234365e-03 7.093658e-03 2.147207e-02 19 52212830 52212833 4 + 2.976 2.919 -0.188
ENSG00000105568 E025 9.1797811 3.212526e-03 3.744681e-01 5.188729e-01 19 52212834 52212954 121 + 0.973 0.869 -0.391
ENSG00000105568 E026 2756.7808280 1.541697e-03 1.636947e-02 4.354137e-02 19 52212955 52213110 156 + 3.347 3.313 -0.113
ENSG00000105568 E027 3004.8094244 1.454124e-04 1.273512e-03 4.888815e-03 19 52215779 52215893 115 + 3.371 3.352 -0.063
ENSG00000105568 E028 1352.2859498 7.352057e-05 5.173746e-01 6.517696e-01 19 52216004 52216005 2 + 3.005 3.009 0.011
ENSG00000105568 E029 2676.0690735 6.087420e-05 1.890571e-02 4.912601e-02 19 52216006 52216074 69 + 3.313 3.303 -0.032
ENSG00000105568 E030 4060.5038419 4.663755e-04 5.265892e-02 1.138873e-01 19 52216529 52216663 135 + 3.496 3.486 -0.032
ENSG00000105568 E031 4172.8898427 9.058890e-05 8.965437e-01 9.378578e-01 19 52219691 52219864 174 + 3.487 3.501 0.045
ENSG00000105568 E032 2261.2806780 8.474112e-04 3.748312e-03 1.243488e-02 19 52220189 52220249 61 + 3.181 3.244 0.208
ENSG00000105568 E033 1607.2002754 1.246641e-04 3.545939e-03 1.185633e-02 19 52220979 52220982 4 + 3.043 3.092 0.162
ENSG00000105568 E034 4071.2060261 4.049272e-04 1.969485e-05 1.223623e-04 19 52220983 52221133 151 + 3.435 3.499 0.214
ENSG00000105568 E035 4663.2982813 1.797078e-03 4.742202e-05 2.687073e-04 19 52222099 52222241 143 + 3.464 3.564 0.332
ENSG00000105568 E036 4126.7193325 3.757325e-03 5.861398e-04 2.482394e-03 19 52225717 52225808 92 + 3.396 3.513 0.391
ENSG00000105568 E037 15.3619823 1.654774e-03 2.241270e-01 3.553433e-01 19 52225809 52225964 156 + 0.973 1.124 0.551
ENSG00000105568 E038 6169.0737346 4.376365e-03 1.755371e-06 1.382628e-05 19 52225965 52229518 3554 + 3.531 3.694 0.540
ENSG00000105568 E039 0.0000000       19 52245573 52245680 108 +