ENSG00000105556

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264819 ENSG00000105556 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER2 protein_coding protein_coding 21.04345 30.28429 17.37416 2.864217 0.8261776 -0.8012721 11.4386793 19.5621853 7.047883 2.3065318 0.1073253 -1.4714974 0.50952917 0.64403333 0.40700000 -0.23703333 4.911777e-07 4.911777e-07 FALSE TRUE
ENST00000586994 ENSG00000105556 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER2 protein_coding retained_intron 21.04345 30.28429 17.37416 2.864217 0.8261776 -0.8012721 1.3810698 0.8835229 1.315466 0.2404265 0.3448793 0.5689235 0.07812917 0.02886667 0.07573333 0.04686667 1.342443e-01 4.911777e-07 FALSE TRUE
ENST00000635755 ENSG00000105556 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER2 protein_coding nonsense_mediated_decay 21.04345 30.28429 17.37416 2.864217 0.8261776 -0.8012721 2.9577965 4.6486261 3.458613 0.4974575 0.9053739 -0.4255457 0.13995833 0.15310000 0.19513333 0.04203333 7.761196e-01 4.911777e-07 FALSE FALSE
MSTRG.15974.4 ENSG00000105556 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER2 protein_coding   21.04345 30.28429 17.37416 2.864217 0.8261776 -0.8012721 2.4070830 2.1994765 3.464662 0.3955866 0.1917323 0.6531680 0.13025833 0.07373333 0.19940000 0.12566667 9.060127e-05 4.911777e-07 FALSE TRUE
MSTRG.15974.5 ENSG00000105556 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER2 protein_coding   21.04345 30.28429 17.37416 2.864217 0.8261776 -0.8012721 0.9623562 0.4729824 1.156474 0.2393513 0.5182169 1.2721113 0.05372083 0.01686667 0.06870000 0.05183333 4.442987e-01 4.911777e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105556 E001 221.084790 0.0073388616 3.877256e-06 2.829626e-05 19 305573 306213 641 - 2.111 2.349 0.796
ENSG00000105556 E002 124.209528 0.0011552439 3.551912e-06 2.615435e-05 19 306214 306476 263 - 1.889 2.084 0.654
ENSG00000105556 E003 187.912606 0.0011589713 4.725166e-03 1.516361e-02 19 306477 306684 208 - 2.143 2.244 0.339
ENSG00000105556 E004 85.627241 0.0010231787 2.665436e-01 4.047605e-01 19 306685 306711 27 - 1.840 1.896 0.189
ENSG00000105556 E005 314.680469 0.0002068284 3.396600e-04 1.539011e-03 19 307119 307536 418 - 2.378 2.465 0.288
ENSG00000105556 E006 145.354160 0.0002789038 2.992336e-03 1.024208e-02 19 308577 308665 89 - 2.032 2.137 0.352
ENSG00000105556 E007 90.123879 0.0003574750 1.157566e-02 3.252704e-02 19 308801 308821 21 - 1.819 1.932 0.381
ENSG00000105556 E008 153.633101 0.0009106887 2.273053e-01 3.591787e-01 19 308822 308925 104 - 2.102 2.149 0.159
ENSG00000105556 E009 149.778578 0.0002799350 2.268360e-01 3.586108e-01 19 311845 311939 95 - 2.090 2.135 0.151
ENSG00000105556 E010 149.571240 0.0061812515 9.756810e-01 9.888291e-01 19 312191 312272 82 - 2.121 2.129 0.024
ENSG00000105556 E011 221.533869 0.0003520882 9.982647e-03 2.872086e-02 19 313492 313643 152 - 2.335 2.275 -0.201
ENSG00000105556 E012 164.825709 0.0007340073 3.672072e-02 8.494055e-02 19 325635 325704 70 - 2.206 2.147 -0.195
ENSG00000105556 E013 167.772166 0.0002398827 5.341309e-03 1.686085e-02 19 326507 326593 87 - 2.225 2.150 -0.251
ENSG00000105556 E014 92.358120 0.0009337589 1.810668e-03 6.632871e-03 19 326594 326598 5 - 2.000 1.880 -0.403
ENSG00000105556 E015 17.650052 0.0114704859 7.832298e-05 4.200678e-04 19 326620 327063 444 - 1.446 1.082 -1.279
ENSG00000105556 E016 8.294282 0.0021337954 2.316427e-02 5.808990e-02 19 327064 327132 69 - 1.081 0.828 -0.946
ENSG00000105556 E017 197.036818 0.0024274807 6.151021e-02 1.291755e-01 19 327133 327256 124 - 2.283 2.227 -0.185
ENSG00000105556 E018 185.845320 0.0009935153 3.196877e-04 1.459617e-03 19 327864 327989 126 - 2.289 2.188 -0.339
ENSG00000105556 E019 4.167386 0.0039754332 5.112863e-01 6.463391e-01 19 330264 330380 117 - 0.589 0.696 0.461
ENSG00000105556 E020 2.210142 0.0088140091 2.672618e-01 4.055585e-01 19 334115 334399 285 - 0.589 0.406 -0.900
ENSG00000105556 E021 149.905793 0.0002692588 1.405392e-05 9.020554e-05 19 334400 334542 143 - 2.211 2.085 -0.422
ENSG00000105556 E022 66.968052 0.0004173743 5.998065e-05 3.313646e-04 19 336083 336173 91 - 1.894 1.719 -0.590
ENSG00000105556 E023 1.318001 0.0199343587 4.530990e-02 1.007575e-01 19 336174 336194 21 - 0.001 0.406 10.191
ENSG00000105556 E024 3.525853 0.0046742885 7.986764e-01 8.715369e-01 19 340514 340607 94 - 0.589 0.634 0.197
ENSG00000105556 E025 3.809015 0.1093452932 7.007888e-02 1.434974e-01 19 343285 343360 76 - 0.859 0.511 -1.472
ENSG00000105556 E026 4.723113 0.0315831923 8.955058e-02 1.744375e-01 19 343677 343809 133 - 0.888 0.634 -1.028
ENSG00000105556 E027 7.462988 0.0025912660 9.931943e-02 1.894516e-01 19 343810 343938 129 - 1.006 0.814 -0.728
ENSG00000105556 E028 40.099016 0.0005983062 1.958813e-02 5.060221e-02 19 344774 344815 42 - 1.646 1.515 -0.445