ENSG00000105552

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316273 ENSG00000105552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCAT2 protein_coding protein_coding 69.41213 121.5665 35.16435 4.788231 0.6787842 -1.789269 36.335812 67.16327 13.693052 2.432244 0.4923863 -2.293390 0.5105333 0.5526333 0.38980000 -0.16283333 4.532811e-08 4.532811e-08 FALSE TRUE
ENST00000545387 ENSG00000105552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCAT2 protein_coding protein_coding 69.41213 121.5665 35.16435 4.788231 0.6787842 -1.789269 9.680144 18.18906 2.891228 1.030677 0.2495881 -2.649128 0.1250667 0.1496667 0.08253333 -0.06713333 5.081550e-04 4.532811e-08 FALSE TRUE
ENST00000597011 ENSG00000105552 HEK293_OSMI2_2hA HEK293_TMG_2hB BCAT2 protein_coding protein_coding 69.41213 121.5665 35.16435 4.788231 0.6787842 -1.789269 11.462056 19.53380 9.534238 1.222545 1.0665875 -1.034009 0.1755167 0.1608000 0.27023333 0.10943333 3.558783e-03 4.532811e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105552 E001 0.5451131 0.6938126727 1.000000e+00 1.000000e+00 19 48795062 48795063 2 - 0.001 0.171 8.457
ENSG00000105552 E002 1.7314586 0.3011690051 1.720588e-01 2.908801e-01 19 48795064 48795064 1 - 0.000 0.422 12.247
ENSG00000105552 E003 64.1217325 0.0056633555 1.390894e-02 3.802044e-02 19 48795065 48795099 35 - 1.536 1.713 0.605
ENSG00000105552 E004 83.1207051 0.0042958478 1.359280e-03 5.174029e-03 19 48795100 48795109 10 - 1.620 1.826 0.698
ENSG00000105552 E005 99.1613938 0.0048735746 2.883083e-04 1.332369e-03 19 48795110 48795118 9 - 1.678 1.904 0.763
ENSG00000105552 E006 1018.4006289 0.0011918844 1.300065e-01 2.341771e-01 19 48795119 48795464 346 - 2.851 2.884 0.108
ENSG00000105552 E007 12.1573154 0.0014480239 5.363049e-03 1.691749e-02 19 48795865 48796146 282 - 1.230 0.936 -1.069
ENSG00000105552 E008 5.8563482 0.0105532280 6.886123e-02 1.414842e-01 19 48796147 48796246 100 - 0.921 0.654 -1.062
ENSG00000105552 E009 3.2901845 0.1017868156 7.544053e-01 8.400625e-01 19 48796247 48796258 12 - 0.564 0.515 -0.232
ENSG00000105552 E010 4.1975620 0.0041494529 8.491179e-01 9.063586e-01 19 48796259 48796329 71 - 0.637 0.604 -0.143
ENSG00000105552 E011 3.3462496 0.0122747851 9.305998e-01 9.603459e-01 19 48796330 48796427 98 - 0.564 0.549 -0.072
ENSG00000105552 E012 597.9162159 0.0001114764 7.800842e-02 1.562712e-01 19 48796428 48796502 75 - 2.618 2.651 0.110
ENSG00000105552 E013 848.6019950 0.0001010428 5.603307e-02 1.197588e-01 19 48796578 48796718 141 - 2.773 2.803 0.099
ENSG00000105552 E014 694.1048195 0.0001987998 3.240526e-01 4.674117e-01 19 48796937 48797022 86 - 2.726 2.709 -0.059
ENSG00000105552 E015 733.3505793 0.0001324760 8.821612e-01 9.285321e-01 19 48797191 48797333 143 - 2.737 2.734 -0.009
ENSG00000105552 E016 10.5004943 0.0047817215 5.887769e-03 1.831650e-02 19 48797334 48797543 210 - 1.195 0.884 -1.139
ENSG00000105552 E017 23.2858237 0.0008260485 2.715066e-03 9.418291e-03 19 48798810 48799674 865 - 1.452 1.207 -0.856
ENSG00000105552 E018 545.0514031 0.0001418534 4.217924e-01 5.649276e-01 19 48799675 48799838 164 - 2.593 2.609 0.052
ENSG00000105552 E019 470.1677722 0.0001291677 7.193269e-01 8.142051e-01 19 48799981 48800065 85 - 2.549 2.541 -0.027
ENSG00000105552 E020 365.6559624 0.0001475028 7.385634e-01 8.284159e-01 19 48800066 48800100 35 - 2.426 2.434 0.025
ENSG00000105552 E021 596.9103298 0.0008164474 9.068330e-01 9.448417e-01 19 48800187 48800297 111 - 2.642 2.645 0.010
ENSG00000105552 E022 717.2720448 0.0009564300 7.412468e-01 8.304768e-01 19 48806517 48806717 201 - 2.729 2.723 -0.021
ENSG00000105552 E023 314.2243617 0.0002111059 8.527039e-01 9.086993e-01 19 48807000 48807012 13 - 2.370 2.364 -0.018
ENSG00000105552 E024 449.3293847 0.0001387342 8.869672e-01 9.317209e-01 19 48807013 48807074 62 - 2.519 2.522 0.009
ENSG00000105552 E025 27.0051354 0.0008459580 9.799417e-11 1.730974e-09 19 48807075 48807755 681 - 1.666 1.207 -1.587
ENSG00000105552 E026 23.6201575 0.0009089887 7.008604e-08 7.331229e-07 19 48807756 48807788 33 - 1.576 1.162 -1.440
ENSG00000105552 E027 83.2053727 0.0107721033 3.225641e-09 4.351548e-08 19 48807789 48808236 448 - 2.087 1.703 -1.292
ENSG00000105552 E028 18.2015245 0.0241515387 1.150160e-04 5.909802e-04 19 48808237 48808311 75 - 1.472 1.049 -1.491
ENSG00000105552 E029 18.4166071 0.0010398587 1.228895e-01 2.240782e-01 19 48810795 48810808 14 - 1.279 1.132 -0.519
ENSG00000105552 E030 104.1623587 0.0003077938 1.614928e-07 1.576378e-06 19 48810809 48810983 175 - 2.061 1.846 -0.721
ENSG00000105552 E031 293.6927243 0.0003751909 1.351640e-03 5.148779e-03 19 48810984 48811177 194 - 2.258 2.351 0.311
ENSG00000105552 E032 3.8521543 0.0083082789 9.841587e-04 3.905035e-03 19 48811275 48811323 49 - 0.954 0.463 -2.071