ENSG00000105497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262259 ENSG00000105497 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF175 protein_coding protein_coding 3.981229 0.8143585 6.697608 0.08000787 0.2619953 3.024455 0.72537707 0.46818256 0.8646956 0.06637445 0.01197947 0.8712195 0.3224167 0.60123333 0.12963333 -0.4716000 3.898863e-03 3.497036e-10 FALSE TRUE
ENST00000545217 ENSG00000105497 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF175 protein_coding protein_coding 3.981229 0.8143585 6.697608 0.08000787 0.2619953 3.024455 0.06976979 0.07142437 0.1078902 0.01416771 0.05517649 0.5339107 0.0425625 0.09206667 0.01666667 -0.0754000 1.435927e-01 3.497036e-10   FALSE
ENST00000596504 ENSG00000105497 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF175 protein_coding protein_coding 3.981229 0.8143585 6.697608 0.08000787 0.2619953 3.024455 1.54852681 0.00000000 2.9418250 0.00000000 0.34461494 8.2054634 0.2383375 0.00000000 0.43693333 0.4369333 3.497036e-10 3.497036e-10   FALSE
ENST00000600460 ENSG00000105497 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF175 protein_coding retained_intron 3.981229 0.8143585 6.697608 0.08000787 0.2619953 3.024455 1.53538352 0.24187349 2.4393150 0.15390481 0.13924913 3.2816071 0.3508708 0.26573333 0.36690000 0.1011667 7.282747e-01 3.497036e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105497 E001 1.4896696 0.0096925312 5.878258e-02 1.245449e-01 19 51571283 51571297 15 + 0.430 0.001 -10.404
ENSG00000105497 E002 1.4896696 0.0096925312 5.878258e-02 1.245449e-01 19 51571298 51571303 6 + 0.430 0.000 -12.094
ENSG00000105497 E003 11.2852385 0.0016043284 6.052380e-03 1.874825e-02 19 51571304 51571475 172 + 1.097 0.731 -1.389
ENSG00000105497 E004 22.3892696 0.0047112160 6.753712e-03 2.058350e-02 19 51573150 51573327 178 + 1.358 1.090 -0.948
ENSG00000105497 E005 18.3566738 0.0013509771 3.449829e-01 4.890641e-01 19 51573328 51573401 74 + 1.244 1.151 -0.331
ENSG00000105497 E006 2.0775423 0.0212916657 5.147723e-02 1.117757e-01 19 51573402 51574210 809 + 0.339 0.677 1.666
ENSG00000105497 E007 0.4720498 0.1839945023 6.037029e-01 7.244320e-01 19 51581368 51581390 23 + 0.126 0.212 0.898
ENSG00000105497 E008 21.0440186 0.0009648594 2.419683e-02 6.021459e-02 19 51581391 51581517 127 + 1.324 1.111 -0.755
ENSG00000105497 E009 0.5891098 0.0184774250 3.794599e-01 5.237294e-01 19 51581518 51581546 29 + 0.224 0.000 -10.924
ENSG00000105497 E010 14.3317482 0.0013584033 3.063598e-02 7.320755e-02 19 51581787 51581882 96 + 1.177 0.930 -0.899
ENSG00000105497 E011 25.5538298 0.0010415694 1.507052e-01 2.626313e-01 19 51586627 51586938 312 + 1.389 1.268 -0.420
ENSG00000105497 E012 146.1316249 0.0008021709 9.361186e-01 9.638219e-01 19 51586939 51589547 2609 + 2.102 2.100 -0.006
ENSG00000105497 E013 43.7719244 0.0007117158 4.140269e-14 1.242848e-12 19 51589548 51592510 2963 + 1.463 1.845 1.297