ENSG00000105486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263274 ENSG00000105486 HEK293_OSMI2_2hA HEK293_TMG_2hB LIG1 protein_coding protein_coding 81.11356 113.7875 60.48393 3.638441 2.034971 -0.9116072 28.444714 45.361892 23.394988 2.4491158 0.794677 -0.9549828 0.3485208 0.40003333 0.3885667 -0.01146667 0.94678722 2.713677e-05 FALSE  
ENST00000596672 ENSG00000105486 HEK293_OSMI2_2hA HEK293_TMG_2hB LIG1 protein_coding nonsense_mediated_decay 81.11356 113.7875 60.48393 3.638441 2.034971 -0.9116072 13.055292 20.703094 7.342982 2.9988136 1.239570 -1.4941418 0.1552125 0.18080000 0.1216000 -0.05920000 0.30059842 2.713677e-05 FALSE  
ENST00000597901 ENSG00000105486 HEK293_OSMI2_2hA HEK293_TMG_2hB LIG1 protein_coding retained_intron 81.11356 113.7875 60.48393 3.638441 2.034971 -0.9116072 8.218751 5.180164 7.127788 1.0263809 1.229850 0.4596968 0.1088958 0.04503333 0.1167667 0.07173333 0.00581636 2.713677e-05    
MSTRG.17420.9 ENSG00000105486 HEK293_OSMI2_2hA HEK293_TMG_2hB LIG1 protein_coding   81.11356 113.7875 60.48393 3.638441 2.034971 -0.9116072 15.572420 22.712128 13.688373 0.5079909 1.208162 -0.7300933 0.2007167 0.20033333 0.2254667 0.02513333 0.60540500 2.713677e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105486 E001 0.4804688 0.0221627191 2.180283e-01 3.480498e-01 19 48115445 48115445 1 - 0.292 0.087 -2.118
ENSG00000105486 E002 0.6256415 0.0175328339 7.812663e-02 1.564627e-01 19 48115446 48115448 3 - 0.387 0.087 -2.703
ENSG00000105486 E003 1.0705211 0.0125877301 5.328430e-01 6.651523e-01 19 48115449 48115449 1 - 0.387 0.275 -0.706
ENSG00000105486 E004 2.5796661 0.0068187884 6.166982e-01 7.347061e-01 19 48115450 48115467 18 - 0.588 0.506 -0.383
ENSG00000105486 E005 8.3623073 0.0484394958 8.807583e-01 9.275348e-01 19 48115468 48115488 21 - 0.913 0.932 0.073
ENSG00000105486 E006 15.5478938 0.0012460403 1.953924e-01 3.204476e-01 19 48115489 48115494 6 - 1.080 1.205 0.446
ENSG00000105486 E007 55.9205376 0.0004470964 3.618314e-01 5.062496e-01 19 48115495 48115523 29 - 1.672 1.720 0.161
ENSG00000105486 E008 627.4875241 0.0014317298 2.151116e-07 2.049191e-06 19 48115524 48115732 209 - 2.653 2.781 0.429
ENSG00000105486 E009 601.4050444 0.0023541419 1.397789e-06 1.124302e-05 19 48115873 48115965 93 - 2.625 2.766 0.469
ENSG00000105486 E010 5.6157000 0.0148148743 8.430614e-01 9.022402e-01 19 48115966 48116174 209 - 0.797 0.769 -0.115
ENSG00000105486 E011 665.7676876 0.0002699926 5.090483e-14 1.509433e-12 19 48117638 48117781 144 - 2.676 2.807 0.437
ENSG00000105486 E012 5.6348158 0.0030210662 8.289523e-01 8.925660e-01 19 48117782 48117880 99 - 0.798 0.768 -0.118
ENSG00000105486 E013 457.4179403 0.0001426496 1.974613e-18 1.048443e-16 19 48119137 48119190 54 - 2.479 2.653 0.580
ENSG00000105486 E014 62.4191577 0.0004088470 4.306186e-08 4.706052e-07 19 48120167 48121169 1003 - 1.919 1.668 -0.849
ENSG00000105486 E015 379.8633820 0.0001522964 1.730202e-14 5.512642e-13 19 48121170 48121196 27 - 2.405 2.571 0.554
ENSG00000105486 E016 607.8433467 0.0001382103 9.368291e-18 4.625475e-16 19 48121197 48121271 75 - 2.622 2.770 0.493
ENSG00000105486 E017 596.9553300 0.0003398671 1.118487e-06 9.192002e-06 19 48121272 48121322 51 - 2.659 2.749 0.301
ENSG00000105486 E018 649.1490061 0.0007310403 2.453133e-04 1.155779e-03 19 48122934 48123016 83 - 2.708 2.783 0.251
ENSG00000105486 E019 860.8951914 0.0015775240 3.332835e-02 7.844300e-02 19 48123174 48123318 145 - 2.848 2.900 0.174
ENSG00000105486 E020 6.8232401 0.0054849566 5.688790e-01 6.954899e-01 19 48123319 48123623 305 - 0.913 0.842 -0.274
ENSG00000105486 E021 606.6660639 0.0005619760 2.180949e-02 5.527932e-02 19 48127277 48127348 72 - 2.700 2.746 0.152
ENSG00000105486 E022 728.6725757 0.0017460376 4.264756e-02 9.590082e-02 19 48127910 48128020 111 - 2.775 2.828 0.176
ENSG00000105486 E023 589.9399978 0.0005707404 6.354532e-02 1.326000e-01 19 48131076 48131171 96 - 2.695 2.732 0.125
ENSG00000105486 E024 603.9206177 0.0001282796 7.945249e-03 2.364145e-02 19 48132982 48133097 116 - 2.698 2.742 0.147
ENSG00000105486 E025 12.8654268 0.0013674106 2.598049e-03 9.059648e-03 19 48133098 48133494 397 - 1.284 1.002 -1.009
ENSG00000105486 E026 498.7613541 0.0003148398 4.689910e-01 6.083125e-01 19 48133981 48134066 86 - 2.636 2.651 0.047
ENSG00000105486 E027 532.9459971 0.0028896640 2.741137e-01 4.132253e-01 19 48135680 48135753 74 - 2.699 2.668 -0.104
ENSG00000105486 E028 359.7669766 0.0008665933 1.403286e-01 2.484773e-01 19 48135754 48135779 26 - 2.531 2.495 -0.118
ENSG00000105486 E029 297.0343011 0.0014417864 3.168912e-02 7.524106e-02 19 48136034 48136043 10 - 2.465 2.404 -0.201
ENSG00000105486 E030 419.3365977 0.0015235415 6.984280e-01 7.983967e-01 19 48136044 48136125 82 - 2.579 2.570 -0.030
ENSG00000105486 E031 469.4166643 0.0001229166 4.163166e-01 5.596947e-01 19 48137008 48137084 77 - 2.632 2.617 -0.050
ENSG00000105486 E032 578.1180458 0.0001335436 5.506174e-01 6.802226e-01 19 48137522 48137688 167 - 2.704 2.714 0.033
ENSG00000105486 E033 39.5311687 0.0096066873 2.409997e-06 1.841961e-05 19 48137689 48137759 71 - 1.775 1.434 -1.161
ENSG00000105486 E034 42.2566084 0.0114418669 5.077248e-08 5.465477e-07 19 48137760 48137891 132 - 1.837 1.436 -1.364
ENSG00000105486 E035 603.0789905 0.0004819157 7.649613e-01 8.478649e-01 19 48139971 48140143 173 - 2.733 2.728 -0.017
ENSG00000105486 E036 349.2675783 0.0015685310 9.187305e-01 9.526505e-01 19 48143543 48143599 57 - 2.489 2.493 0.014
ENSG00000105486 E037 460.5923480 0.0001312491 3.311306e-01 4.747151e-01 19 48143883 48143963 81 - 2.625 2.607 -0.060
ENSG00000105486 E038 342.9040876 0.0001372471 5.117491e-02 1.112519e-01 19 48149763 48149802 40 - 2.516 2.475 -0.137
ENSG00000105486 E039 268.2921924 0.0001555345 1.271211e-05 8.245808e-05 19 48149803 48149809 7 - 2.451 2.349 -0.341
ENSG00000105486 E040 287.4025688 0.0001561309 1.279011e-05 8.289025e-05 19 48149810 48149825 16 - 2.479 2.381 -0.329
ENSG00000105486 E041 316.8535224 0.0001481175 6.953433e-04 2.882044e-03 19 48149826 48149841 16 - 2.504 2.430 -0.246
ENSG00000105486 E042 381.4102320 0.0001476163 3.412143e-03 1.147335e-02 19 48150088 48150131 44 - 2.573 2.515 -0.196
ENSG00000105486 E043 398.0198201 0.0002867230 1.566560e-01 2.706474e-01 19 48150132 48150172 41 - 2.572 2.543 -0.097
ENSG00000105486 E044 391.9163002 0.0014059322 3.081740e-02 7.355942e-02 19 48150173 48150210 38 - 2.585 2.529 -0.188
ENSG00000105486 E045 447.8021231 0.0010004574 5.778730e-03 1.803029e-02 19 48151232 48151301 70 - 2.649 2.585 -0.213
ENSG00000105486 E046 323.4437789 0.0002134492 1.778904e-04 8.691152e-04 19 48151302 48151336 35 - 2.520 2.439 -0.272
ENSG00000105486 E047 148.4023395 0.0002456874 6.315364e-05 3.469010e-04 19 48151337 48151339 3 - 2.210 2.085 -0.417
ENSG00000105486 E048 3.9243785 0.0071479188 2.767613e-04 1.285092e-03 19 48151340 48151385 46 - 0.962 0.442 -2.207
ENSG00000105486 E049 329.1164332 0.0001656732 4.511653e-06 3.244948e-05 19 48153872 48153900 29 - 2.538 2.441 -0.325
ENSG00000105486 E050 429.8348932 0.0005008102 1.051798e-05 6.957887e-05 19 48153901 48153967 67 - 2.649 2.558 -0.305
ENSG00000105486 E051 2.2883784 0.0064962397 1.580488e-01 2.725308e-01 19 48153968 48154207 240 - 0.639 0.406 -1.118
ENSG00000105486 E052 0.1472490 0.0426127140 2.263097e-01   19 48154393 48154564 172 - 0.170 0.000 -10.170
ENSG00000105486 E053 447.7055296 0.0002597352 5.915137e-05 3.272700e-04 19 48157014 48157140 127 - 2.656 2.579 -0.257
ENSG00000105486 E054 0.2955422 0.0288995454 5.714287e-01   19 48161174 48161371 198 - 0.170 0.087 -1.121
ENSG00000105486 E055 302.3309457 0.0005133755 1.021593e-02 2.929815e-02 19 48161372 48161437 66 - 2.475 2.413 -0.207
ENSG00000105486 E056 378.7191241 0.0012568969 2.553974e-03 8.924519e-03 19 48161438 48161507 70 - 2.583 2.506 -0.257
ENSG00000105486 E057 290.4031687 0.0001715371 3.983457e-07 3.592564e-06 19 48162262 48162283 22 - 2.494 2.380 -0.381
ENSG00000105486 E058 368.5603332 0.0006393538 3.297078e-07 3.024363e-06 19 48162284 48162351 68 - 2.597 2.481 -0.387
ENSG00000105486 E059 379.1390305 0.0067781569 1.679770e-03 6.218050e-03 19 48165550 48165623 74 - 2.623 2.488 -0.451
ENSG00000105486 E060 1.3974999 0.0102208078 3.330676e-02 7.840290e-02 19 48165624 48165627 4 - 0.588 0.221 -2.119
ENSG00000105486 E061 0.0000000       19 48169609 48169689 81 -      
ENSG00000105486 E062 0.9630260 0.0863422407 9.225692e-01 9.551648e-01 19 48169974 48170240 267 - 0.292 0.273 -0.131
ENSG00000105486 E063 273.2116781 0.0105305065 4.837908e-03 1.548031e-02 19 48170241 48170637 397 - 2.490 2.341 -0.498