ENSG00000105483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447740 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding protein_coding 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 0.2872672 0.5085537 0.0000000 0.25713775 0.0000000 -5.6964216 0.02159583 0.05043333 0.00000000 -0.05043333 1.301056e-01 3.233594e-10 FALSE TRUE
ENST00000518450 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding nonsense_mediated_decay 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 0.8742458 0.7730485 0.8620703 0.06201901 0.1429536 0.1553428 0.07560833 0.07686667 0.05316667 -0.02370000 3.259771e-01 3.233594e-10   FALSE
ENST00000519332 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding protein_coding 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 1.1981957 1.6827885 1.9786606 0.23648542 0.4986090 0.2323954 0.10178750 0.16673333 0.12473333 -0.04200000 6.634229e-01 3.233594e-10   FALSE
ENST00000519940 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding protein_coding 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 0.8379718 0.2638881 1.6636097 0.05272129 0.2911514 2.6113048 0.05982083 0.02626667 0.10166667 0.07540000 2.036148e-04 3.233594e-10 FALSE TRUE
ENST00000520007 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding protein_coding 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 2.2103552 3.2106894 2.3141672 0.10696257 0.7113588 -0.4706557 0.17617500 0.31943333 0.14176667 -0.17766667 2.137357e-02 3.233594e-10   FALSE
ENST00000520753 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding protein_coding 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 0.8903173 0.0000000 0.6108989 0.00000000 0.3883996 5.9562866 0.05677083 0.00000000 0.03630000 0.03630000 2.562637e-01 3.233594e-10 FALSE TRUE
ENST00000522051 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding retained_intron 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 1.0070622 0.2358543 1.4889615 0.03649982 0.1343834 2.6080878 0.07357083 0.02340000 0.09250000 0.06910000 9.550401e-06 3.233594e-10 FALSE TRUE
ENST00000522889 ENSG00000105483 HEK293_OSMI2_2hA HEK293_TMG_2hB CARD8 protein_coding protein_coding 13.0734 10.05306 16.12978 0.1714306 0.8995848 0.6815513 0.2030585 0.0000000 0.8195949 0.00000000 0.1116499 6.3743351 0.01425417 0.00000000 0.05036667 0.05036667 3.233594e-10 3.233594e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105483 E001 12.2346042 0.0014223995 4.456049e-02 9.939073e-02 19 48180770 48183092 2323 - 1.026 1.226 0.720
ENSG00000105483 E002 1.8143660 0.0092759477 2.173601e-01 3.472084e-01 19 48186550 48186765 216 - 0.343 0.561 1.135
ENSG00000105483 E003 0.4847352 0.2569392599 1.000000e+00 1.000000e+00 19 48187678 48187770 93 - 0.171 0.159 -0.128
ENSG00000105483 E004 2.9421314 0.0136207866 3.731484e-02 8.606159e-02 19 48189443 48189565 123 - 0.429 0.766 1.523
ENSG00000105483 E005 3.5523563 0.0085683029 5.521296e-03 1.734245e-02 19 48190496 48190600 105 - 0.429 0.855 1.872
ENSG00000105483 E006 5.4365514 0.0724837312 8.758357e-03 2.568053e-02 19 48191914 48191982 69 - 0.563 1.012 1.805
ENSG00000105483 E007 9.3203967 0.0018331507 1.182702e-11 2.432520e-10 19 48193017 48193181 165 - 0.532 1.309 3.010
ENSG00000105483 E008 16.8481335 0.0011296920 5.124265e-03 1.626691e-02 19 48203146 48203631 486 - 1.138 1.378 0.844
ENSG00000105483 E009 13.7174270 0.0305223489 6.158800e-02 1.293031e-01 19 48203632 48203843 212 - 1.055 1.287 0.824
ENSG00000105483 E010 17.2026675 0.0538748625 2.583874e-02 6.360705e-02 19 48203844 48204243 400 - 1.100 1.407 1.081
ENSG00000105483 E011 1.8349900 0.0147424975 1.556046e-02 4.175648e-02 19 48206384 48206520 137 - 0.236 0.655 2.286
ENSG00000105483 E012 0.4481018 0.0808226846 3.122147e-01 4.547478e-01 19 48208086 48208103 18 - 0.094 0.272 1.858
ENSG00000105483 E013 46.1215697 0.0292060244 7.751078e-03 2.315460e-02 19 48208104 48209643 1540 - 1.531 1.820 0.984
ENSG00000105483 E014 4.5039339 0.0043808730 4.588139e-01 5.990849e-01 19 48209644 48209667 24 - 0.686 0.798 0.457
ENSG00000105483 E015 81.1505918 0.0100775408 4.091278e-02 9.272406e-02 19 48209668 48210486 819 - 1.846 1.988 0.476
ENSG00000105483 E016 39.7380838 0.0005704804 5.211215e-01 6.550132e-01 19 48210487 48210786 300 - 1.609 1.585 -0.085
ENSG00000105483 E017 12.7025391 0.0016644817 8.568247e-03 2.521003e-02 19 48210787 48210789 3 - 1.208 0.951 -0.934
ENSG00000105483 E018 68.8192554 0.0025151028 8.686794e-02 1.703804e-01 19 48210790 48211151 362 - 1.860 1.788 -0.243
ENSG00000105483 E019 54.0608881 0.0013853792 2.499780e-01 3.858900e-01 19 48211152 48211376 225 - 1.749 1.702 -0.160
ENSG00000105483 E020 43.6365503 0.0010552850 6.665181e-01 7.739542e-01 19 48211377 48211565 189 - 1.644 1.632 -0.042
ENSG00000105483 E021 29.1709583 0.0049847498 8.093998e-01 8.789615e-01 19 48211566 48211616 51 - 1.475 1.471 -0.016
ENSG00000105483 E022 51.9272853 0.0088455687 1.241477e-01 2.258999e-01 19 48211617 48211826 210 - 1.749 1.660 -0.300
ENSG00000105483 E023 32.4688164 0.0072349492 3.450897e-02 8.073129e-02 19 48211827 48211896 70 - 1.569 1.423 -0.500
ENSG00000105483 E024 31.2035850 0.0006903673 1.395048e-04 7.014002e-04 19 48211897 48211975 79 - 1.580 1.336 -0.840
ENSG00000105483 E025 0.6695470 0.0180928561 1.171229e-01 2.158380e-01 19 48215138 48215339 202 - 0.094 0.365 2.455
ENSG00000105483 E026 26.7296482 0.0026331869 1.146009e-03 4.457519e-03 19 48215340 48215384 45 - 1.512 1.280 -0.803
ENSG00000105483 E027 30.8543569 0.0007856524 2.094443e-04 1.004343e-03 19 48218871 48218992 122 - 1.575 1.336 -0.821
ENSG00000105483 E028 15.7605756 0.0011811324 1.415158e-02 3.856961e-02 19 48218993 48219012 20 - 1.290 1.079 -0.751
ENSG00000105483 E029 35.5214946 0.0012777402 3.518293e-03 1.177948e-02 19 48221730 48221855 126 - 1.612 1.438 -0.595
ENSG00000105483 E030 8.8811806 0.0019278680 9.468638e-01 9.706489e-01 19 48223719 48223868 150 - 0.974 0.992 0.066
ENSG00000105483 E031 46.0801804 0.0005024317 4.945550e-01 6.314908e-01 19 48230438 48230697 260 - 1.674 1.649 -0.083
ENSG00000105483 E032 11.0721842 0.0538662259 6.768638e-01 7.817052e-01 19 48230698 48230700 3 - 1.089 1.035 -0.198
ENSG00000105483 E033 33.5853417 0.0006381588 3.042702e-01 4.462851e-01 19 48230777 48230948 172 - 1.549 1.497 -0.179
ENSG00000105483 E034 24.8084262 0.0007723975 5.863310e-01 7.099175e-01 19 48230949 48231006 58 - 1.382 1.431 0.170
ENSG00000105483 E035 37.6473000 0.0005471527 7.683923e-01 8.503387e-01 19 48231660 48231728 69 - 1.580 1.575 -0.019
ENSG00000105483 E036 31.5466193 0.0012616935 5.543827e-01 6.833680e-01 19 48231729 48231810 82 - 1.512 1.484 -0.094
ENSG00000105483 E037 0.9254501 0.0133394653 8.930317e-01 9.356335e-01 19 48231811 48232114 304 - 0.293 0.274 -0.129
ENSG00000105483 E038 26.8047768 0.0008018847 7.509003e-01 8.374836e-01 19 48232453 48232493 41 - 1.435 1.424 -0.037
ENSG00000105483 E039 11.1158488 0.0015470169 3.433275e-04 1.553473e-03 19 48232494 48232789 296 - 1.188 0.798 -1.449
ENSG00000105483 E040 18.8407091 0.0039572269 2.216924e-08 2.563413e-07 19 48232790 48233271 482 - 1.439 0.905 -1.911
ENSG00000105483 E041 9.9413183 0.0049950110 2.908191e-04 1.342532e-03 19 48233272 48233404 133 - 1.160 0.732 -1.614
ENSG00000105483 E042 4.1861213 0.0188229322 1.645525e-02 4.373945e-02 19 48233405 48233409 5 - 0.830 0.441 -1.714
ENSG00000105483 E043 10.9982976 0.0106338394 1.039476e-03 4.095705e-03 19 48233410 48233820 411 - 1.188 0.798 -1.448
ENSG00000105483 E044 7.7437106 0.1879381324 9.056176e-01 9.439563e-01 19 48233821 48233845 25 - 0.913 0.948 0.132
ENSG00000105483 E045 13.0795221 0.1378667226 7.204256e-01 8.150348e-01 19 48233846 48233980 135 - 1.160 1.095 -0.233
ENSG00000105483 E046 9.6359571 0.0345511224 3.157700e-02 7.502562e-02 19 48233981 48234277 297 - 1.107 0.803 -1.138
ENSG00000105483 E047 6.0036976 0.0028294555 1.467662e-02 3.976207e-02 19 48234278 48234402 125 - 0.939 0.611 -1.320
ENSG00000105483 E048 37.1528959 0.0008873296 1.228335e-01 2.240019e-01 19 48234403 48234471 69 - 1.602 1.520 -0.277
ENSG00000105483 E049 30.8576583 0.0006385296 2.263302e-01 3.579963e-01 19 48234472 48234543 72 - 1.518 1.452 -0.229
ENSG00000105483 E050 1.3191365 0.0145625967 9.223143e-01 9.549787e-01 19 48238262 48238333 72 - 0.343 0.366 0.138
ENSG00000105483 E051 1.6825452 0.1640207028 4.735948e-01 6.125303e-01 19 48238334 48238335 2 - 0.343 0.510 0.897
ENSG00000105483 E052 13.7175562 0.0022543161 2.841585e-04 1.315438e-03 19 48238336 48238382 47 - 0.985 1.328 1.227
ENSG00000105483 E053 50.2733186 0.0004557710 4.206782e-02 9.485162e-02 19 48238383 48238474 92 - 1.653 1.765 0.379
ENSG00000105483 E054 41.0559684 0.0005556057 9.909711e-03 2.854093e-02 19 48238475 48238526 52 - 1.546 1.698 0.517
ENSG00000105483 E055 25.9933051 0.0030591041 7.537309e-02 1.521168e-01 19 48238527 48238532 6 - 1.359 1.497 0.475
ENSG00000105483 E056 63.8241165 0.0004781828 2.395999e-02 5.972015e-02 19 48240962 48241063 102 - 1.756 1.867 0.374
ENSG00000105483 E057 6.0401275 0.0026489465 1.739891e-01 2.933659e-01 19 48242540 48242644 105 - 0.902 0.733 -0.664
ENSG00000105483 E058 10.9142097 0.0181338042 1.152204e-02 3.239897e-02 19 48246075 48246381 307 - 1.167 0.855 -1.153
ENSG00000105483 E059 50.9579470 0.0005034231 3.050604e-02 7.296238e-02 19 48249523 48249633 111 - 1.660 1.778 0.398
ENSG00000105483 E060 4.7131768 0.0346404769 3.531691e-01 4.974149e-01 19 48249634 48249750 117 - 0.799 0.655 -0.589
ENSG00000105483 E061 50.6391224 0.0053420333 2.372177e-02 5.923783e-02 19 48249751 48249847 97 - 1.644 1.791 0.498
ENSG00000105483 E062 1.2638536 0.0394354407 4.534126e-01 5.941432e-01 19 48249848 48249878 31 - 0.293 0.440 0.866
ENSG00000105483 E063 38.1960695 0.0066582209 8.806124e-02 1.721772e-01 19 48255792 48255946 155 - 1.534 1.663 0.440