ENSG00000105438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330720 ENSG00000105438 HEK293_OSMI2_2hA HEK293_TMG_2hB KDELR1 protein_coding protein_coding 369.4877 524.5211 285.0851 22.5263 3.670307 -0.8795851 321.02954 500.8018701 234.888565 36.0004756 3.085132 -1.092231 0.85191667 0.95233333 0.82440000 -0.12793333 0.042151830 0.001048708 FALSE TRUE
ENST00000599084 ENSG00000105438 HEK293_OSMI2_2hA HEK293_TMG_2hB KDELR1 protein_coding retained_intron 369.4877 524.5211 285.0851 22.5263 3.670307 -0.8795851 24.26810 0.6644386 39.269848 0.6644386 2.764455 5.863959 0.07744167 0.00120000 0.13756667 0.13636667 0.001048708 0.001048708 FALSE TRUE
MSTRG.17434.5 ENSG00000105438 HEK293_OSMI2_2hA HEK293_TMG_2hB KDELR1 protein_coding   369.4877 524.5211 285.0851 22.5263 3.670307 -0.8795851 17.38548 15.5885831 4.799483 15.5885831 4.799483 -1.697461 0.05103750 0.03243333 0.01656667 -0.01586667 0.997690392 0.001048708 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105438 E001 24.685221 6.888827e-03 6.065028e-07 5.278639e-06 19 48382575 48382577 3 - 0.944 1.456 1.824
ENSG00000105438 E002 827.376519 1.650637e-03 1.359288e-15 5.053240e-14 19 48382578 48382723 146 - 2.710 2.913 0.676
ENSG00000105438 E003 667.137874 1.774531e-03 2.503732e-17 1.158302e-15 19 48382724 48382742 19 - 2.594 2.825 0.767
ENSG00000105438 E004 6934.020170 2.770368e-04 1.044786e-35 2.663951e-33 19 48382743 48383327 585 - 3.711 3.814 0.344
ENSG00000105438 E005 1944.979983 1.732733e-04 1.153739e-02 3.243587e-02 19 48384230 48384238 9 - 3.251 3.229 -0.074
ENSG00000105438 E006 4170.171803 1.188081e-04 5.861893e-01 7.097916e-01 19 48384239 48384367 129 - 3.566 3.567 0.002
ENSG00000105438 E007 3968.160858 1.678609e-04 6.622990e-05 3.618995e-04 19 48384368 48384482 115 - 3.565 3.538 -0.090
ENSG00000105438 E008 9.503200 5.353124e-02 7.290268e-01 8.213273e-01 19 48386926 48387061 136 - 1.010 0.965 -0.166
ENSG00000105438 E009 3.069700 5.587346e-03 1.368608e-01 2.437105e-01 19 48387755 48387821 67 - 0.731 0.502 -1.008
ENSG00000105438 E010 1.730590 9.005070e-03 9.571838e-01 9.771805e-01 19 48389482 48389552 71 - 0.391 0.402 0.064
ENSG00000105438 E011 4592.265099 5.473412e-05 5.210314e-12 1.136663e-10 19 48389553 48389711 159 - 3.636 3.598 -0.126
ENSG00000105438 E012 12.611866 2.218617e-03 2.935088e-02 7.068320e-02 19 48390199 48390423 225 - 1.232 1.024 -0.745
ENSG00000105438 E013 3452.227737 4.366730e-04 9.442428e-14 2.694847e-12 19 48390424 48390524 101 - 3.540 3.463 -0.254
ENSG00000105438 E014 50.031079 1.476702e-03 8.218023e-08 8.487133e-07 19 48390525 48390855 331 - 1.836 1.553 -0.962
ENSG00000105438 E015 18.930218 9.642283e-04 6.609859e-07 5.708507e-06 19 48390893 48390969 77 - 1.494 1.106 -1.358
ENSG00000105438 E016 3635.539818 2.082352e-03 6.655826e-03 2.032965e-02 19 48391268 48391551 284 - 3.543 3.495 -0.161
ENSG00000105438 E017 0.699736 1.671312e-02 1.790023e-01 2.998888e-01 19 48394055 48394104 50 - 0.000 0.272 9.803