ENSG00000105429

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251268 ENSG00000105429 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF8 protein_coding protein_coding 36.69574 50.48843 20.37649 2.757681 0.5459559 -1.308625 1.9024971 1.351031 1.765818 0.465847 0.4685259 0.38378419 0.05978750 0.02670000 0.0877000 0.06100000 0.1299386882 3.64461e-05 FALSE TRUE
ENST00000593647 ENSG00000105429 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF8 protein_coding protein_coding 36.69574 50.48843 20.37649 2.757681 0.5459559 -1.308625 16.1258439 28.960603 5.954482 2.361645 0.2829849 -2.28012104 0.40084583 0.57526667 0.2919000 -0.28336667 0.0000364461 3.64461e-05 FALSE TRUE
MSTRG.17232.3 ENSG00000105429 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF8 protein_coding   36.69574 50.48843 20.37649 2.757681 0.5459559 -1.308625 6.3482640 4.871897 5.420908 2.381882 0.1900334 0.15375176 0.18120000 0.09773333 0.2664000 0.16866667 0.0535587775 3.64461e-05 FALSE TRUE
MSTRG.17232.4 ENSG00000105429 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF8 protein_coding   36.69574 50.48843 20.37649 2.757681 0.5459559 -1.308625 7.7988739 5.928115 5.974864 3.119918 0.2361584 0.01131352 0.23202500 0.11946667 0.2930333 0.17356667 0.1025672122 3.64461e-05 FALSE TRUE
MSTRG.17232.5 ENSG00000105429 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF8 protein_coding   36.69574 50.48843 20.37649 2.757681 0.5459559 -1.308625 0.9475888 3.759190 0.000000 2.059534 0.0000000 -8.55811081 0.02000417 0.07246667 0.0000000 -0.07246667 0.2315966588 3.64461e-05 FALSE TRUE
MSTRG.17232.9 ENSG00000105429 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF8 protein_coding   36.69574 50.48843 20.37649 2.757681 0.5459559 -1.308625 2.0029376 4.469273 0.000000 2.289006 0.0000000 -8.80712084 0.05369167 0.08586667 0.0000000 -0.08586667 0.0004990781 3.64461e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105429 E001 2.6412903 0.0076877517 9.845886e-01 9.944307e-01 19 42325609 42325631 23 + 0.498 0.540 0.203
ENSG00000105429 E002 3.3681078 0.0981124367 6.627920e-01 7.710216e-01 19 42325632 42325634 3 + 0.498 0.655 0.713
ENSG00000105429 E003 6.2748399 0.0883727105 5.767802e-01 7.021545e-01 19 42325635 42325651 17 + 0.845 0.819 -0.104
ENSG00000105429 E004 6.6917086 0.0384613809 2.738332e-01 4.129272e-01 19 42325652 42325654 3 + 0.919 0.813 -0.406
ENSG00000105429 E005 46.7741401 0.0180116017 1.643918e-02 4.370042e-02 19 42325655 42325725 71 + 1.734 1.601 -0.454
ENSG00000105429 E006 172.7528359 0.0166130606 1.739855e-05 1.094106e-04 19 42325726 42326091 366 + 2.346 2.124 -0.741
ENSG00000105429 E007 176.6968490 0.0126441333 6.695266e-05 3.654062e-04 19 42326092 42326430 339 + 2.327 2.154 -0.577
ENSG00000105429 E008 115.5818172 0.0074771777 4.525784e-06 3.254369e-05 19 42333605 42333768 164 + 2.146 1.966 -0.604
ENSG00000105429 E009 129.1234057 0.0004590551 1.472406e-15 5.445974e-14 19 42334007 42334213 207 + 2.207 2.001 -0.689
ENSG00000105429 E010 129.2311570 0.0015188199 9.024179e-14 2.580144e-12 19 42335035 42335215 181 + 2.213 2.000 -0.715
ENSG00000105429 E011 104.5702961 0.0042646084 8.654226e-06 5.833206e-05 19 42335297 42335385 89 + 2.087 1.937 -0.502
ENSG00000105429 E012 170.8859750 0.0054047308 5.141506e-05 2.888278e-04 19 42335931 42336211 281 + 2.279 2.160 -0.398
ENSG00000105429 E013 134.9829571 0.0013432973 6.434695e-07 5.567889e-06 19 42336212 42336346 135 + 2.176 2.056 -0.402
ENSG00000105429 E014 136.8269702 0.0085874263 1.299828e-04 6.588155e-04 19 42336807 42336952 146 + 2.199 2.055 -0.483
ENSG00000105429 E015 129.0247028 0.0015322842 1.968120e-08 2.298308e-07 19 42337084 42337206 123 + 2.174 2.025 -0.497
ENSG00000105429 E016 125.2929841 0.0059852193 3.385487e-04 1.534783e-03 19 42343477 42343631 155 + 2.142 2.027 -0.386
ENSG00000105429 E017 114.6724588 0.0149983970 2.485369e-02 6.156918e-02 19 42343954 42344073 120 + 2.084 2.002 -0.274
ENSG00000105429 E018 128.7977306 0.0090488143 2.506152e-02 6.200073e-02 19 42344441 42344585 145 + 2.120 2.059 -0.204
ENSG00000105429 E019 162.2640828 0.0149316419 4.122452e-04 1.821457e-03 19 42344670 42344833 164 + 2.286 2.120 -0.556
ENSG00000105429 E020 188.4535250 0.0040365314 1.599249e-09 2.283486e-08 19 42348272 42348472 201 + 2.357 2.176 -0.602
ENSG00000105429 E021 111.8194571 0.0031194924 1.355718e-03 5.162028e-03 19 42349499 42349699 201 + 2.070 1.989 -0.271
ENSG00000105429 E022 181.2623510 0.0038001554 1.637475e-06 1.298024e-05 19 42350148 42350384 237 + 2.310 2.180 -0.434
ENSG00000105429 E023 135.3553041 0.0002570572 8.745858e-07 7.353111e-06 19 42351216 42351334 119 + 2.166 2.065 -0.339
ENSG00000105429 E024 143.4468693 0.0004268034 2.891635e-10 4.718445e-09 19 42351429 42351560 132 + 2.216 2.074 -0.476
ENSG00000105429 E025 133.5128564 0.0004255749 3.870102e-07 3.498327e-06 19 42351648 42351761 114 + 2.165 2.055 -0.368
ENSG00000105429 E026 159.3673846 0.0058354723 5.940645e-03 1.845252e-02 19 42352208 42352456 249 + 2.217 2.149 -0.227
ENSG00000105429 E027 0.9297165 0.0697627233 1.222323e-01 2.231267e-01 19 42352796 42352927 132 + 0.434 0.174 -1.805
ENSG00000105429 E028 110.2104993 0.0040500725 5.014015e-01 6.375555e-01 19 42352928 42353127 200 + 1.989 2.019 0.101
ENSG00000105429 E029 143.1436816 0.0153972469 5.127163e-01 6.476157e-01 19 42353465 42353675 211 + 2.106 2.136 0.102
ENSG00000105429 E030 194.1431095 0.0099922250 2.805595e-01 4.204099e-01 19 42353775 42354024 250 + 2.251 2.262 0.036
ENSG00000105429 E031 135.1372529 0.0051239072 7.301620e-01 8.222004e-01 19 42354588 42354720 133 + 2.068 2.115 0.157
ENSG00000105429 E032 182.0220754 0.0002010811 6.833654e-01 7.865698e-01 19 42355758 42356005 248 + 2.195 2.240 0.148
ENSG00000105429 E033 156.3450758 0.0002530072 9.918070e-01 9.989670e-01 19 42356083 42356193 111 + 2.123 2.179 0.188
ENSG00000105429 E034 173.3721594 0.0002239189 4.806023e-01 6.188566e-01 19 42356335 42356453 119 + 2.182 2.217 0.118
ENSG00000105429 E035 206.8111445 0.0004634483 8.744281e-01 9.232806e-01 19 42356774 42356981 208 + 2.247 2.299 0.174
ENSG00000105429 E036 217.6607204 0.0014974850 3.312864e-01 4.748846e-01 19 42357404 42357584 181 + 2.284 2.313 0.095
ENSG00000105429 E037 221.8823715 0.0013138857 1.204392e-01 2.205932e-01 19 42358144 42358307 164 + 2.303 2.315 0.040
ENSG00000105429 E038 17.1127241 0.0011261651 1.777614e-02 4.665608e-02 19 42358787 42358954 168 + 1.317 1.171 -0.515
ENSG00000105429 E039 216.4653336 0.0024927065 8.206032e-01 8.868636e-01 19 42359098 42359242 145 + 2.265 2.319 0.178
ENSG00000105429 E040 240.4333725 0.0005734928 6.344679e-01 7.489208e-01 19 42360775 42360969 195 + 2.316 2.361 0.149
ENSG00000105429 E041 132.9090221 0.0002722868 8.115176e-01 8.803788e-01 19 42360970 42361006 37 + 2.047 2.110 0.214
ENSG00000105429 E042 190.8269486 0.0002303938 3.110001e-01 4.534492e-01 19 42362090 42362213 124 + 2.188 2.273 0.283
ENSG00000105429 E043 249.5577364 0.0001773149 3.227596e-02 7.638551e-02 19 42362384 42362597 214 + 2.285 2.395 0.366
ENSG00000105429 E044 227.8142195 0.0015347259 3.801882e-03 1.258659e-02 19 42363048 42363262 215 + 2.219 2.369 0.503
ENSG00000105429 E045 195.8534661 0.0001843598 4.446326e-01 5.861899e-01 19 42368455 42368662 208 + 2.205 2.282 0.257
ENSG00000105429 E046 190.3772439 0.0002454566 2.377695e-01 3.715628e-01 19 42368843 42369002 160 + 2.182 2.272 0.300
ENSG00000105429 E047 141.1414441 0.0002890150 9.462302e-01 9.702424e-01 19 42369531 42369630 100 + 2.077 2.135 0.194
ENSG00000105429 E048 169.7909842 0.0015339507 6.899989e-01 7.918046e-01 19 42369631 42369723 93 + 2.145 2.218 0.243
ENSG00000105429 E049 274.4720194 0.0002647908 6.777957e-01 7.824170e-01 19 42370189 42370359 171 + 2.356 2.423 0.222
ENSG00000105429 E050 0.5149242 0.2121162305 1.000000e+00 1.000000e+00 19 42370628 42370700 73 + 0.155 0.175 0.205
ENSG00000105429 E051 280.3300233 0.0001647617 2.744418e-01 4.135915e-01 19 42370701 42370831 131 + 2.356 2.437 0.272
ENSG00000105429 E052 150.6445656 0.0003967054 4.419363e-01 5.836058e-01 19 42371350 42371482 133 + 2.087 2.168 0.271
ENSG00000105429 E053 259.8771219 0.0001847907 8.887154e-01 9.328217e-01 19 42375507 42376250 744 + 2.343 2.396 0.176
ENSG00000105429 E054 3275.3240833 0.0125452108 3.010041e-07 2.784663e-06 19 42376251 42378699 2449 + 3.281 3.557 0.917
ENSG00000105429 E055 136.6927838 0.0177921975 2.996741e-02 7.189652e-02 19 42378700 42378769 70 + 1.948 2.170 0.746