ENSG00000105426

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262963 ENSG00000105426 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRS protein_coding protein_coding 29.14205 36.87042 23.9217 2.885183 0.6526219 -0.6239325 6.6718203 12.3702255 3.133900 0.5963875 0.29503978 -1.97741056 0.20983750 0.34213333 0.13170000 -0.210433333 2.296031e-04 1.256803e-31 FALSE TRUE
ENST00000591760 ENSG00000105426 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRS protein_coding protein_coding 29.14205 36.87042 23.9217 2.885183 0.6526219 -0.6239325 5.2525916 9.4315193 4.236145 1.0705657 0.94047219 -1.15286556 0.16467083 0.25440000 0.17580000 -0.078600000 2.752400e-01 1.256803e-31   FALSE
ENST00000592099 ENSG00000105426 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRS protein_coding protein_coding 29.14205 36.87042 23.9217 2.885183 0.6526219 -0.6239325 3.9436549 0.2718559 4.968051 0.2718559 0.26424486 4.14255120 0.16117083 0.00660000 0.20843333 0.201833333 3.838292e-03 1.256803e-31 FALSE TRUE
MSTRG.16239.17 ENSG00000105426 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRS protein_coding   29.14205 36.87042 23.9217 2.885183 0.6526219 -0.6239325 1.6294141 1.9373406 2.015537 0.4234198 0.52193951 0.05679946 0.05659167 0.05156667 0.08326667 0.031700000 5.032773e-01 1.256803e-31 FALSE TRUE
MSTRG.16239.4 ENSG00000105426 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRS protein_coding   29.14205 36.87042 23.9217 2.885183 0.6526219 -0.6239325 3.5155485 3.7486612 2.149886 0.9488195 0.41496519 -0.79926384 0.11973333 0.09916667 0.08953333 -0.009633333 9.312466e-01 1.256803e-31 FALSE TRUE
MSTRG.16239.5 ENSG00000105426 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRS protein_coding   29.14205 36.87042 23.9217 2.885183 0.6526219 -0.6239325 4.9072276 5.5674785 3.347304 1.0818061 0.35647864 -0.73230984 0.17139167 0.14803333 0.14066667 -0.007366667 9.498535e-01 1.256803e-31 FALSE TRUE
MSTRG.16239.8 ENSG00000105426 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRS protein_coding   29.14205 36.87042 23.9217 2.885183 0.6526219 -0.6239325 0.5124684 0.0000000 1.641790 0.0000000 0.03266335 7.36788673 0.02038750 0.00000000 0.06876667 0.068766667 1.256803e-31 1.256803e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105426 E001 0.5503986 0.0202066697 1.000000e+00 1.000000e+00 19 5158495 5159104 610 - 0.156 0.174 0.187
ENSG00000105426 E002 0.5149242 0.2509352187 1.000000e+00 1.000000e+00 19 5173969 5174082 114 - 0.156 0.174 0.190
ENSG00000105426 E003 234.9497505 0.0216170089 4.159196e-09 5.496667e-08 19 5205508 5205647 140 - 1.946 2.451 1.690
ENSG00000105426 E004 223.4950104 0.0231602507 9.614673e-08 9.791802e-07 19 5205648 5205668 21 - 1.950 2.425 1.590
ENSG00000105426 E005 189.8358828 0.0208371302 9.671958e-09 1.196190e-07 19 5205669 5205671 3 - 1.862 2.358 1.662
ENSG00000105426 E006 595.6107404 0.0166147602 8.797531e-15 2.918343e-13 19 5205672 5205945 274 - 2.313 2.858 1.815
ENSG00000105426 E007 260.4997589 0.0086173530 6.476489e-25 7.043350e-23 19 5205946 5206069 124 - 1.894 2.508 2.053
ENSG00000105426 E008 153.1128204 0.0030982552 2.485187e-27 3.317909e-25 19 5206070 5206120 51 - 1.726 2.270 1.827
ENSG00000105426 E009 257.9113830 0.0004161856 1.090265e-49 6.454606e-47 19 5206121 5206367 247 - 2.016 2.484 1.563
ENSG00000105426 E010 86.2449918 0.0003080773 2.419167e-13 6.512775e-12 19 5206368 5206432 65 - 1.623 1.994 1.252
ENSG00000105426 E011 59.3311264 0.0004356310 4.851365e-02 1.065324e-01 19 5206433 5206516 84 - 1.649 1.783 0.452
ENSG00000105426 E012 45.0860396 0.0091560506 4.632872e-01 6.030947e-01 19 5206517 5206536 20 - 1.571 1.660 0.302
ENSG00000105426 E013 62.4332607 0.0021550753 2.035095e-01 3.306023e-01 19 5206537 5206577 41 - 1.697 1.799 0.345
ENSG00000105426 E014 216.6226641 0.0001909902 1.653124e-06 1.308895e-05 19 5206578 5206842 265 - 2.183 2.348 0.549
ENSG00000105426 E015 173.9576828 0.0033256296 4.092061e-04 1.809844e-03 19 5207922 5208042 121 - 2.077 2.258 0.607
ENSG00000105426 E016 86.5338375 0.0032380828 9.831641e-05 5.140418e-04 19 5208043 5208057 15 - 1.730 1.967 0.799
ENSG00000105426 E017 227.1056740 0.0003909491 2.000561e-05 1.240990e-04 19 5208237 5208391 155 - 2.213 2.364 0.506
ENSG00000105426 E018 219.1175594 0.0004540628 4.531990e-02 1.007773e-01 19 5210469 5210594 126 - 2.244 2.334 0.300
ENSG00000105426 E019 261.2180524 0.0002215099 4.879758e-01 6.256044e-01 19 5210679 5210805 127 - 2.373 2.391 0.060
ENSG00000105426 E020 302.5978041 0.0002277426 4.888138e-02 1.071660e-01 19 5211590 5211768 179 - 2.453 2.444 -0.030
ENSG00000105426 E021 310.0893360 0.0025250205 3.637045e-02 8.428675e-02 19 5211965 5212250 286 - 2.477 2.449 -0.094
ENSG00000105426 E022 205.6799231 0.0027428018 1.697816e-02 4.488629e-02 19 5212337 5212491 155 - 2.312 2.264 -0.160
ENSG00000105426 E023 177.4495962 0.0014906902 8.118921e-03 2.408520e-02 19 5214361 5214480 120 - 2.250 2.199 -0.173
ENSG00000105426 E024 232.8444953 0.0012415478 5.913593e-07 5.158926e-06 19 5214561 5214736 176 - 2.406 2.298 -0.362
ENSG00000105426 E025 180.3036088 0.0002110201 4.476190e-06 3.222377e-05 19 5215289 5215366 78 - 2.286 2.193 -0.308
ENSG00000105426 E026 146.6654576 0.0002256520 2.561082e-07 2.403474e-06 19 5215367 5215412 46 - 2.215 2.093 -0.408
ENSG00000105426 E027 181.1665209 0.0006188519 1.914928e-11 3.807087e-10 19 5215498 5215595 98 - 2.327 2.167 -0.533
ENSG00000105426 E028 10.8804082 0.0016764934 2.382480e-03 8.405567e-03 19 5216720 5216767 48 - 1.207 0.935 -0.990
ENSG00000105426 E029 166.1718834 0.0035262935 2.475861e-04 1.165241e-03 19 5218420 5218532 113 - 2.260 2.151 -0.364
ENSG00000105426 E030 12.0721352 0.0147467278 2.050003e-06 1.590885e-05 19 5218533 5218786 254 - 1.354 0.868 -1.758
ENSG00000105426 E031 30.1989677 0.0105554927 2.260300e-03 8.031042e-03 19 5218787 5218798 12 - 1.586 1.378 -0.717
ENSG00000105426 E032 20.4176473 0.0081932726 2.364435e-07 2.234536e-06 19 5218799 5219309 511 - 1.529 1.117 -1.442
ENSG00000105426 E033 170.1045142 0.0091564441 5.705217e-03 1.783087e-02 19 5219310 5219467 158 - 2.268 2.162 -0.354
ENSG00000105426 E034 174.0828975 0.0053696154 2.434245e-03 8.564432e-03 19 5219939 5220154 216 - 2.271 2.175 -0.321
ENSG00000105426 E035 121.9047617 0.0002482725 4.448119e-08 4.847462e-07 19 5220260 5220353 94 - 2.149 2.002 -0.492
ENSG00000105426 E036 211.7602799 0.0013290159 5.342843e-15 1.830354e-13 19 5221000 5221253 254 - 2.418 2.220 -0.661
ENSG00000105426 E037 108.8999438 0.0003452532 1.720172e-13 4.735273e-12 19 5222123 5222220 98 - 2.143 1.920 -0.748
ENSG00000105426 E038 184.8850231 0.0139844669 3.208671e-04 1.464331e-03 19 5222689 5223297 609 - 2.351 2.171 -0.604
ENSG00000105426 E039 55.6619393 0.0091399156 4.496667e-04 1.965438e-03 19 5225727 5225844 118 - 1.840 1.646 -0.659
ENSG00000105426 E040 0.0000000       19 5229316 5229342 27 -      
ENSG00000105426 E041 59.2371361 0.0206299921 8.134752e-05 4.343341e-04 19 5229491 5229684 194 - 1.917 1.635 -0.954
ENSG00000105426 E042 117.9398156 0.0097358238 1.839230e-06 1.442145e-05 19 5231310 5231615 306 - 2.187 1.951 -0.792
ENSG00000105426 E043 77.9992488 0.0045482791 1.525777e-06 1.218082e-05 19 5238919 5239063 145 - 1.994 1.781 -0.715
ENSG00000105426 E044 40.1805816 0.0127598579 3.789496e-03 1.255264e-02 19 5240199 5240238 40 - 1.701 1.513 -0.640
ENSG00000105426 E045 65.4011414 0.0080642386 3.397472e-03 1.143113e-02 19 5240239 5240332 94 - 1.881 1.737 -0.489
ENSG00000105426 E046 248.6869673 0.0062536432 1.505354e-10 2.577126e-09 19 5243901 5244482 582 - 2.515 2.273 -0.806
ENSG00000105426 E047 162.2641912 0.0049653868 2.383707e-13 6.426443e-12 19 5245776 5246045 270 - 2.349 2.067 -0.943
ENSG00000105426 E048 0.2924217 0.0290785164 7.728508e-02   19 5256108 5256119 12 - 0.270 0.000 -12.046
ENSG00000105426 E049 94.5891556 0.0088101699 2.613657e-09 3.587259e-08 19 5258017 5258127 111 - 2.130 1.823 -1.030
ENSG00000105426 E050 0.4751703 0.0220879433 1.000000e+00 1.000000e+00 19 5260805 5260822 18 - 0.156 0.173 0.183
ENSG00000105426 E051 0.5202097 0.0204050958 2.620901e-01 3.998147e-01 19 5262964 5262972 9 - 0.270 0.095 -1.813
ENSG00000105426 E052 126.8143606 0.0050110410 2.601912e-20 1.722308e-18 19 5265008 5265196 189 - 2.298 1.908 -1.308
ENSG00000105426 E053 15.4353618 0.0139698480 1.107334e-01 2.066096e-01 19 5269947 5270089 143 - 1.271 1.139 -0.468
ENSG00000105426 E054 22.5716884 0.0287468637 7.654701e-02 1.539693e-01 19 5273061 5273326 266 - 1.170 1.413 0.849
ENSG00000105426 E055 209.4302830 0.0020081592 3.412971e-03 1.147553e-02 19 5273442 5273548 107 - 2.331 2.271 -0.201
ENSG00000105426 E056 145.5133214 0.0014848784 3.038416e-02 7.271679e-02 19 5273549 5273583 35 - 2.162 2.121 -0.138
ENSG00000105426 E057 241.8101017 0.0016744813 2.737004e-01 4.127796e-01 19 5274199 5274344 146 - 2.351 2.354 0.008
ENSG00000105426 E058 183.2944778 0.0029102400 4.007716e-01 5.444485e-01 19 5286050 5286234 185 - 2.229 2.234 0.018
ENSG00000105426 E059 0.1817044 0.0396799578 9.131519e-01   19 5286235 5286388 154 - 0.000 0.095 9.142
ENSG00000105426 E060 0.0000000       19 5292731 5292787 57 -      
ENSG00000105426 E061 51.6764158 0.0077694965 9.824974e-01 9.931021e-01 19 5293141 5293262 122 - 1.661 1.699 0.127
ENSG00000105426 E062 17.3668944 0.0147929817 5.603209e-04 2.385901e-03 19 5340664 5340852 189 - 1.415 1.109 -1.080