ENSG00000105419

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000441740 ENSG00000105419 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS3 protein_coding protein_coding 8.783089 15.43777 7.056801 0.569649 0.2942408 -1.12827 2.1429582 4.2085421 1.4143738 0.3434267 0.20507882 -1.56641667 0.25102083 0.2727333 0.1990333 -0.073700000 0.28664627 0.008836793 FALSE  
ENST00000558555 ENSG00000105419 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS3 protein_coding protein_coding 8.783089 15.43777 7.056801 0.569649 0.2942408 -1.12827 3.2165092 5.1273351 2.8510198 0.5235812 0.32824377 -0.84449068 0.35350000 0.3315000 0.4052667 0.073766667 0.57796383 0.008836793 FALSE  
ENST00000559524 ENSG00000105419 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS3 protein_coding protein_coding 8.783089 15.43777 7.056801 0.569649 0.2942408 -1.12827 1.1794585 2.1572186 0.9238720 0.1538195 0.05707514 -1.21454801 0.14145000 0.1394667 0.1312000 -0.008266667 0.90519268 0.008836793 FALSE  
ENST00000560245 ENSG00000105419 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS3 protein_coding protein_coding 8.783089 15.43777 7.056801 0.569649 0.2942408 -1.12827 0.6545066 1.7079345 0.0000000 0.8672968 0.00000000 -7.42453119 0.06457917 0.1100333 0.0000000 -0.110033333 0.22847425 0.008836793 FALSE  
ENST00000560253 ENSG00000105419 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS3 protein_coding processed_transcript 8.783089 15.43777 7.056801 0.569649 0.2942408 -1.12827 0.5923567 0.9156683 0.8664985 0.1363266 0.08410403 -0.07874379 0.06350000 0.0593000 0.1223000 0.063000000 0.01435849 0.008836793 FALSE  
ENST00000607695 ENSG00000105419 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS3 protein_coding protein_coding 8.783089 15.43777 7.056801 0.569649 0.2942408 -1.12827 0.5188178 0.8632315 0.6156770 0.1781211 0.09107629 -0.48094596 0.06702500 0.0569000 0.0874000 0.030500000 0.49032741 0.008836793 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105419 E001 0.3332198 0.0284521244 4.938728e-01   19 47403124 47403124 1 - 0.182 0.080 -1.358
ENSG00000105419 E002 0.3332198 0.0284521244 4.938728e-01   19 47403125 47403125 1 - 0.182 0.080 -1.358
ENSG00000105419 E003 1.7567414 0.2623367035 5.540262e-01 0.6830751899 19 47403126 47403127 2 - 0.489 0.354 -0.722
ENSG00000105419 E004 125.6530119 0.0009089980 5.479379e-04 0.0023392720 19 47403128 47403553 426 - 1.934 2.065 0.440
ENSG00000105419 E005 37.2350593 0.0007084230 2.426151e-02 0.0603510088 19 47405956 47406459 504 - 1.388 1.541 0.527
ENSG00000105419 E006 82.0881032 0.0004743661 4.535360e-03 0.0146418042 19 47406460 47406526 67 - 1.754 1.882 0.432
ENSG00000105419 E007 81.9113193 0.0003309187 8.781437e-01 0.9257514901 19 47406888 47406971 84 - 1.847 1.852 0.018
ENSG00000105419 E008 59.5744918 0.0004184718 7.770823e-01 0.8565140384 19 47407079 47407097 19 - 1.725 1.709 -0.053
ENSG00000105419 E009 75.4968267 0.0004373617 9.755566e-01 0.9887399922 19 47407098 47407137 40 - 1.813 1.811 -0.009
ENSG00000105419 E010 95.2727670 0.0003393816 9.909054e-01 0.9984419353 19 47407352 47407428 77 - 1.915 1.914 -0.006
ENSG00000105419 E011 9.5398699 0.0018479139 9.416930e-01 0.9673410979 19 47407429 47407468 40 - 0.970 0.961 -0.036
ENSG00000105419 E012 16.0074796 0.0388417311 5.090677e-01 0.6444156620 19 47407469 47407566 98 - 1.234 1.156 -0.275
ENSG00000105419 E013 5.8227637 0.0029266283 2.542810e-01 0.3909421304 19 47407567 47407635 69 - 0.891 0.738 -0.599
ENSG00000105419 E014 132.2886072 0.0002918016 2.909674e-01 0.4317844383 19 47409099 47409247 149 - 2.084 2.048 -0.122
ENSG00000105419 E015 96.0919762 0.0021442285 7.660590e-01 0.8486645056 19 47409436 47409547 112 - 1.926 1.912 -0.047
ENSG00000105419 E016 1.3704169 0.0106989919 1.986747e-01 0.3245298451 19 47412235 47412387 153 - 0.489 0.259 -1.357
ENSG00000105419 E017 76.5250879 0.0004054990 7.964328e-01 0.8700720154 19 47414717 47414815 99 - 1.810 1.820 0.035
ENSG00000105419 E018 29.9313938 0.0006898696 4.029961e-01 0.5467960695 19 47414816 47414835 20 - 1.464 1.405 -0.205
ENSG00000105419 E019 33.3469073 0.0034613319 2.600610e-01 0.3975419430 19 47414836 47414866 31 - 1.522 1.443 -0.273
ENSG00000105419 E020 0.9211812 0.0138246082 1.413237e-01 0.2498468940 19 47414867 47415050 184 - 0.000 0.305 11.893
ENSG00000105419 E021 43.7872166 0.0006364000 6.696784e-01 0.7763834401 19 47415051 47415062 12 - 1.597 1.571 -0.090
ENSG00000105419 E022 55.2981003 0.0054771445 5.716143e-01 0.6978567601 19 47415063 47415101 39 - 1.703 1.670 -0.113
ENSG00000105419 E023 4.4308440 0.0036817254 4.231789e-05 0.0002425277 19 47415876 47416651 776 - 1.016 0.452 -2.357
ENSG00000105419 E024 66.7964212 0.0005279350 9.696820e-01 0.9850260601 19 47416652 47416702 51 - 1.762 1.759 -0.011
ENSG00000105419 E025 0.6599951 0.0201399383 2.202197e-01 0.3506791968 19 47416703 47416803 101 - 0.000 0.258 11.561
ENSG00000105419 E026 95.5866920 0.0002910642 3.915044e-01 0.5354221889 19 47416804 47416963 160 - 1.942 1.907 -0.118
ENSG00000105419 E027 72.6581090 0.0020159191 2.191176e-01 0.3493089547 19 47417178 47417350 173 - 1.847 1.786 -0.204
ENSG00000105419 E028 0.1451727 0.0430137098 1.875314e-01   19 47417351 47417471 121 - 0.182 0.000 -12.351
ENSG00000105419 E029 0.9170311 0.0763836226 6.789722e-02 0.1398797799 19 47417472 47417898 427 - 0.489 0.148 -2.362
ENSG00000105419 E030 0.3299976 0.0278529364 6.011545e-01   19 47418170 47418801 632 - 0.000 0.148 10.568
ENSG00000105419 E031 41.6565960 0.0199185977 5.242865e-01 0.6578608914 19 47419070 47419431 362 - 1.609 1.551 -0.200
ENSG00000105419 E032 14.9811361 0.0012418408 5.528893e-01 0.6821137384 19 47419432 47419527 96 - 1.096 1.153 0.205