ENSG00000105401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222005 ENSG00000105401 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC37 protein_coding protein_coding 346.1394 573.992 200.6567 11.10016 2.643108 -1.516254 137.03441 235.19494 61.83869 18.403254 1.4234813 -1.9271034 0.37884167 0.4104667 0.3082000 -0.10226667 0.1117737171 2.086428e-23 FALSE  
ENST00000591248 ENSG00000105401 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC37 protein_coding retained_intron 346.1394 573.992 200.6567 11.10016 2.643108 -1.516254 22.94747 22.36409 20.29731 3.947909 1.2993564 -0.1398302 0.07780833 0.0391000 0.1010333 0.06193333 0.0002195973 2.086428e-23 TRUE  
MSTRG.16408.11 ENSG00000105401 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC37 protein_coding   346.1394 573.992 200.6567 11.10016 2.643108 -1.516254 165.95958 285.36912 106.54905 22.541625 0.7339945 -1.4212266 0.48455417 0.4962667 0.5311333 0.03486667 0.7150067299 2.086428e-23 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105401 E001 5.697081 3.103739e-03 8.358148e-01 8.973438e-01 19 10391121 10391126 6 - 0.726 0.750 0.099
ENSG00000105401 E002 9.444288 1.877564e-03 7.807442e-02 1.563830e-01 19 10391127 10391132 6 - 0.726 0.965 0.929
ENSG00000105401 E003 78.653521 1.496521e-02 6.094388e-02 1.282250e-01 19 10391133 10391160 28 - 1.675 1.823 0.502
ENSG00000105401 E004 85.815829 1.777244e-02 1.424650e-01 2.513884e-01 19 10391161 10391168 8 - 1.738 1.855 0.397
ENSG00000105401 E005 113.092346 1.343209e-02 8.495628e-02 1.673343e-01 19 10391169 10391184 16 - 1.853 1.974 0.405
ENSG00000105401 E006 430.534116 6.520277e-03 6.944295e-02 1.424354e-01 19 10391185 10391217 33 - 2.466 2.542 0.254
ENSG00000105401 E007 854.669163 2.880003e-03 3.087018e-03 1.052190e-02 19 10391218 10391285 68 - 2.756 2.840 0.278
ENSG00000105401 E008 1187.612360 3.136126e-03 3.991525e-04 1.771168e-03 19 10391286 10391427 142 - 2.884 2.985 0.335
ENSG00000105401 E009 639.196028 4.025934e-03 1.967314e-02 5.079134e-02 19 10391428 10391452 25 - 2.636 2.712 0.254
ENSG00000105401 E010 1288.368767 3.130402e-03 1.333761e-02 3.670656e-02 19 10391453 10391517 65 - 2.948 3.015 0.221
ENSG00000105401 E011 3080.310178 6.979646e-04 5.830451e-04 2.471331e-03 19 10391518 10391706 189 - 3.347 3.389 0.137
ENSG00000105401 E012 2.927836 4.117217e-02 1.088902e-01 2.039055e-01 19 10392776 10393084 309 - 0.726 0.435 -1.327
ENSG00000105401 E013 3.510425 5.731173e-03 2.443316e-01 3.792832e-01 19 10393085 10393085 1 - 0.726 0.532 -0.849
ENSG00000105401 E014 1459.287298 2.388599e-04 8.427155e-04 3.411323e-03 19 10393086 10393094 9 - 3.028 3.064 0.122
ENSG00000105401 E015 1936.024250 6.741990e-05 3.973180e-06 2.892580e-05 19 10393095 10393157 63 - 3.147 3.187 0.133
ENSG00000105401 E016 1030.561822 1.416858e-04 3.136964e-02 7.462359e-02 19 10393259 10393259 1 - 2.888 2.911 0.076
ENSG00000105401 E017 1239.721717 8.080895e-05 5.299469e-04 2.271473e-03 19 10393260 10393279 20 - 2.957 2.994 0.122
ENSG00000105401 E018 1210.543611 1.131316e-04 2.634445e-03 9.173393e-03 19 10393280 10393290 11 - 2.950 2.982 0.105
ENSG00000105401 E019 3233.854581 4.951176e-05 4.210070e-06 3.045846e-05 19 10393291 10393407 117 - 3.379 3.407 0.095
ENSG00000105401 E020 2212.647246 7.046732e-05 2.363168e-01 3.699012e-01 19 10393408 10393437 30 - 3.235 3.238 0.008
ENSG00000105401 E021 1651.925343 2.500737e-04 9.912510e-01 9.986442e-01 19 10393438 10393441 4 - 3.118 3.108 -0.033
ENSG00000105401 E022 10.344082 1.712346e-03 5.846495e-02 1.240037e-01 19 10393442 10393786 345 - 1.125 0.905 -0.812
ENSG00000105401 E023 1673.305582 4.854995e-04 2.708230e-01 4.094832e-01 19 10395021 10395022 2 - 3.110 3.117 0.022
ENSG00000105401 E024 1873.645506 1.871937e-04 1.679848e-02 4.449072e-02 19 10395023 10395038 16 - 3.149 3.168 0.063
ENSG00000105401 E025 3544.896793 6.008251e-05 2.071731e-02 5.299245e-02 19 10395039 10395143 105 - 3.434 3.444 0.031
ENSG00000105401 E026 3712.927052 6.285610e-05 1.089290e-01 2.039501e-01 19 10395228 10395343 116 - 3.460 3.463 0.011
ENSG00000105401 E027 200.259329 7.084519e-03 2.480564e-12 5.707254e-11 19 10395344 10395434 91 - 2.456 2.103 -1.178
ENSG00000105401 E028 2969.894615 6.712946e-05 1.917505e-02 4.972019e-02 19 10395435 10395495 61 - 3.389 3.360 -0.097
ENSG00000105401 E029 2641.077126 1.703177e-04 1.356393e-06 1.094864e-05 19 10395496 10395543 48 - 3.360 3.302 -0.195
ENSG00000105401 E030 228.804751 2.354377e-03 9.196398e-01 9.532311e-01 19 10395544 10395696 153 - 2.263 2.249 -0.047
ENSG00000105401 E031 4.575912 8.250575e-03 3.984836e-03 1.310048e-02 19 10395697 10395837 141 - 0.955 0.532 -1.738
ENSG00000105401 E032 5796.603914 7.530649e-04 9.905849e-05 5.174208e-04 19 10395928 10396203 276 - 3.704 3.643 -0.204
ENSG00000105401 E033 11.870158 1.681792e-03 7.219748e-05 3.908443e-04 19 10400575 10400689 115 - 1.304 0.896 -1.480
ENSG00000105401 E034 5.140729 3.979908e-01 5.768459e-01 7.022028e-01 19 10400690 10400693 4 - 0.775 0.672 -0.420
ENSG00000105401 E035 2904.133531 1.165460e-03 2.076162e-09 2.897831e-08 19 10403378 10403457 80 - 3.446 3.331 -0.385
ENSG00000105401 E036 1991.347897 1.439875e-03 5.614776e-08 5.983252e-07 19 10403458 10403595 138 - 3.286 3.166 -0.400
ENSG00000105401 E037 2.370063 7.468370e-03 2.448059e-02 6.081529e-02 19 10404522 10404560 39 - 0.726 0.343 -1.847
ENSG00000105401 E038 8.677067 2.030571e-03 3.447181e-02 8.066328e-02 19 10419461 10419515 55 - 1.083 0.824 -0.973
ENSG00000105401 E039 12.093315 3.088833e-03 2.316611e-05 1.415224e-04 19 10419516 10419597 82 - 1.330 0.896 -1.569
ENSG00000105401 E040 10.596743 1.642524e-03 2.289847e-06 1.758145e-05 19 10420047 10420446 400 - 1.317 0.823 -1.803