ENSG00000105397

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524462 ENSG00000105397 HEK293_OSMI2_2hA HEK293_TMG_2hB TYK2 protein_coding protein_coding 58.75792 72.09849 37.38477 8.295555 2.348136 -0.9473326 1.541092 4.891375 0.000000 1.5178269 0.0000000 -8.9370428 0.02020000 0.06650000 0.00000000 -0.066500000 3.991231e-11 3.991231e-11 FALSE TRUE
ENST00000524470 ENSG00000105397 HEK293_OSMI2_2hA HEK293_TMG_2hB TYK2 protein_coding retained_intron 58.75792 72.09849 37.38477 8.295555 2.348136 -0.9473326 6.400722 6.322859 3.084715 1.9026827 0.3223078 -1.0330502 0.10348750 0.08543333 0.08413333 -0.001300000 9.984927e-01 3.991231e-11   FALSE
ENST00000525621 ENSG00000105397 HEK293_OSMI2_2hA HEK293_TMG_2hB TYK2 protein_coding protein_coding 58.75792 72.09849 37.38477 8.295555 2.348136 -0.9473326 17.501445 22.535888 11.722367 2.4414774 0.2161181 -0.9423702 0.31316667 0.32026667 0.31530000 -0.004966667 1.000000e+00 3.991231e-11 FALSE TRUE
ENST00000525976 ENSG00000105397 HEK293_OSMI2_2hA HEK293_TMG_2hB TYK2 protein_coding protein_coding 58.75792 72.09849 37.38477 8.295555 2.348136 -0.9473326 5.887441 12.778594 1.351476 4.0096904 0.3605832 -3.2316142 0.08154167 0.17103333 0.03566667 -0.135366667 1.091334e-02 3.991231e-11 FALSE FALSE
ENST00000529412 ENSG00000105397 HEK293_OSMI2_2hA HEK293_TMG_2hB TYK2 protein_coding retained_intron 58.75792 72.09849 37.38477 8.295555 2.348136 -0.9473326 5.857418 3.739978 4.752999 0.6187647 0.4727901 0.3449881 0.10549167 0.05366667 0.12660000 0.072933333 5.425821e-03 3.991231e-11 FALSE TRUE
ENST00000529739 ENSG00000105397 HEK293_OSMI2_2hA HEK293_TMG_2hB TYK2 protein_coding retained_intron 58.75792 72.09849 37.38477 8.295555 2.348136 -0.9473326 5.830218 5.840611 3.670616 1.2622043 0.5233351 -0.6686400 0.10233333 0.08026667 0.09773333 0.017466667 6.904759e-01 3.991231e-11 FALSE TRUE
ENST00000530220 ENSG00000105397 HEK293_OSMI2_2hA HEK293_TMG_2hB TYK2 protein_coding retained_intron 58.75792 72.09849 37.38477 8.295555 2.348136 -0.9473326 3.280615 3.261327 1.983764 0.9940497 0.1216594 -0.7143816 0.05411250 0.04400000 0.05350000 0.009500000 7.227383e-01 3.991231e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105397 E001 6.6121230 0.0071630593 6.430091e-01 7.556460e-01 19 10350529 10350532 4 - 0.791 0.863 0.285
ENSG00000105397 E002 14.4113576 0.0384072910 8.070062e-02 1.606440e-01 19 10350533 10350541 9 - 0.954 1.212 0.936
ENSG00000105397 E003 329.3721527 0.0059682041 2.259194e-09 3.136203e-08 19 10350542 10350747 206 - 2.250 2.537 0.957
ENSG00000105397 E004 244.6142257 0.0068597561 4.495968e-08 4.893696e-07 19 10350748 10350787 40 - 2.117 2.408 0.974
ENSG00000105397 E005 250.5601864 0.0039882059 1.135566e-10 1.986056e-09 19 10350788 10350852 65 - 2.132 2.417 0.952
ENSG00000105397 E006 361.9255706 0.0062450561 3.139996e-04 1.436763e-03 19 10350853 10350946 94 - 2.380 2.557 0.591
ENSG00000105397 E007 209.6765325 0.0024134318 2.907298e-03 9.991453e-03 19 10350947 10350968 22 - 2.184 2.309 0.415
ENSG00000105397 E008 18.1758468 0.0298049291 7.469027e-02 1.510429e-01 19 10350969 10351051 83 - 1.373 1.174 -0.700
ENSG00000105397 E009 298.8833861 0.0031369368 5.270372e-05 2.952615e-04 19 10351052 10351162 111 - 2.310 2.471 0.537
ENSG00000105397 E010 22.9422747 0.0022566494 8.414325e-01 9.011077e-01 19 10351163 10351293 131 - 1.317 1.345 0.098
ENSG00000105397 E011 14.7456238 0.0079145912 5.345565e-06 3.779300e-05 19 10351421 10351484 64 - 1.406 0.982 -1.511
ENSG00000105397 E012 247.9938157 0.0005235414 3.832913e-03 1.267294e-02 19 10352434 10352551 118 - 2.281 2.373 0.305
ENSG00000105397 E013 216.8653142 0.0002087826 3.407815e-03 1.146023e-02 19 10352926 10353021 96 - 2.219 2.312 0.310
ENSG00000105397 E014 190.2250767 0.0008349695 4.468624e-04 1.954940e-03 19 10353022 10353098 77 - 2.137 2.263 0.423
ENSG00000105397 E015 45.4350911 0.0254732958 1.829720e-03 6.694766e-03 19 10353099 10353256 158 - 1.787 1.523 -0.898
ENSG00000105397 E016 193.3248818 0.0009665306 6.085273e-08 6.444749e-07 19 10353528 10353646 119 - 2.089 2.283 0.647
ENSG00000105397 E017 100.7405915 0.0153514101 1.911575e-02 4.959154e-02 19 10353647 10353910 264 - 2.054 1.913 -0.474
ENSG00000105397 E018 75.9975083 0.0004956563 2.587496e-11 5.036406e-10 19 10353911 10354041 131 - 2.009 1.741 -0.903
ENSG00000105397 E019 344.1644623 0.0001484130 3.203580e-02 7.592483e-02 19 10354042 10354234 193 - 2.446 2.504 0.195
ENSG00000105397 E020 180.3357638 0.0006225178 6.113030e-01 7.304201e-01 19 10354512 10354537 26 - 2.189 2.217 0.095
ENSG00000105397 E021 226.7025506 0.0001885863 9.850196e-01 9.946539e-01 19 10354538 10354609 72 - 2.297 2.310 0.043
ENSG00000105397 E022 255.5896167 0.0003171753 2.136412e-01 3.428201e-01 19 10356568 10356718 151 - 2.325 2.369 0.148
ENSG00000105397 E023 20.9586334 0.0304642405 3.664387e-03 1.219469e-02 19 10356719 10357084 366 - 1.480 1.180 -1.045
ENSG00000105397 E024 13.5607256 0.0013869193 4.539655e-06 3.263229e-05 19 10357385 10357763 379 - 1.364 0.959 -1.448
ENSG00000105397 E025 128.0586499 0.0002418714 5.189250e-01 6.530583e-01 19 10357764 10357793 30 - 2.034 2.069 0.116
ENSG00000105397 E026 199.8793932 0.0002339503 4.652894e-01 6.050068e-01 19 10357794 10357918 125 - 2.228 2.261 0.110
ENSG00000105397 E027 224.6433863 0.0002035001 7.801480e-01 8.586857e-01 19 10358003 10358138 136 - 2.289 2.308 0.066
ENSG00000105397 E028 233.3049212 0.0001845365 8.471047e-01 9.050386e-01 19 10359175 10359302 128 - 2.306 2.323 0.058
ENSG00000105397 E029 3.9310665 0.0598774656 8.440361e-01 9.029007e-01 19 10360962 10361073 112 - 0.678 0.643 -0.146
ENSG00000105397 E030 0.9243042 0.0145798626 3.609412e-01 5.053143e-01 19 10361305 10361510 206 - 0.382 0.224 -1.066
ENSG00000105397 E031 191.8599574 0.0002212513 4.209290e-01 5.640862e-01 19 10361511 10361598 88 - 2.241 2.231 -0.034
ENSG00000105397 E032 173.9752473 0.0002179019 9.122528e-01 9.483850e-01 19 10361770 10361836 67 - 2.187 2.196 0.030
ENSG00000105397 E033 235.5037673 0.0026030113 4.894801e-01 6.269050e-01 19 10361837 10361955 119 - 2.300 2.338 0.129
ENSG00000105397 E034 223.9815101 0.0002302544 8.801087e-01 9.271127e-01 19 10362078 10362181 104 - 2.293 2.309 0.054
ENSG00000105397 E035 0.8803962 0.0135212562 5.614933e-01 6.892907e-01 19 10362182 10362183 2 - 0.167 0.279 0.937
ENSG00000105397 E036 290.8632567 0.0003764423 3.552895e-01 4.996402e-01 19 10362264 10362456 193 - 2.424 2.414 -0.032
ENSG00000105397 E037 150.5028132 0.0002598240 2.606867e-02 6.408526e-02 19 10362549 10362579 31 - 2.172 2.115 -0.192
ENSG00000105397 E038 179.8042458 0.0007754231 6.252523e-02 1.308951e-01 19 10362580 10362657 78 - 2.242 2.197 -0.150
ENSG00000105397 E039 202.2217477 0.0029386520 9.507426e-01 9.731666e-01 19 10364614 10364771 158 - 2.250 2.266 0.054
ENSG00000105397 E040 196.2603592 0.0001957942 8.495428e-01 9.066361e-01 19 10364851 10365048 198 - 2.233 2.250 0.059
ENSG00000105397 E041 326.2367571 0.0001883977 1.802764e-04 8.792302e-04 19 10365517 10365898 382 - 2.511 2.443 -0.226
ENSG00000105397 E042 242.6633116 0.0002305159 6.729564e-09 8.568424e-08 19 10366417 10366580 164 - 2.425 2.296 -0.431
ENSG00000105397 E043 106.5054433 0.0003906388 2.477914e-04 1.166062e-03 19 10368055 10368062 8 - 2.065 1.943 -0.410
ENSG00000105397 E044 166.0666737 0.0006112362 8.740360e-07 7.350120e-06 19 10368063 10368121 59 - 2.267 2.129 -0.462
ENSG00000105397 E045 127.4682039 0.0002924909 3.779055e-06 2.765706e-05 19 10368122 10368163 42 - 2.156 2.014 -0.474
ENSG00000105397 E046 100.1313551 0.0044704340 3.038389e-03 1.037796e-02 19 10368164 10368202 39 - 2.042 1.913 -0.434
ENSG00000105397 E047 88.9523566 0.0039343773 2.993316e-03 1.024414e-02 19 10368295 10368328 34 - 1.993 1.861 -0.442
ENSG00000105397 E048 121.5840907 0.0011737802 3.783851e-06 2.768895e-05 19 10368329 10368371 43 - 2.143 1.985 -0.527
ENSG00000105397 E049 117.1509629 0.0002883717 4.110973e-07 3.698588e-06 19 10368372 10368418 47 - 2.131 1.968 -0.544
ENSG00000105397 E050 0.4031496 0.0244106737 4.977288e-01 6.342622e-01 19 10368419 10368531 113 - 0.001 0.162 8.334
ENSG00000105397 E051 3.7557935 0.0056160239 1.900844e-01 3.138835e-01 19 10368532 10368741 210 - 0.756 0.569 -0.798
ENSG00000105397 E052 4.3985137 0.1033726768 1.742415e-01 2.937026e-01 19 10369757 10369877 121 - 0.853 0.600 -1.041
ENSG00000105397 E053 193.3158790 0.0054740794 6.958032e-05 3.779723e-04 19 10378214 10378426 213 - 2.347 2.189 -0.529
ENSG00000105397 E054 0.0000000       19 10378427 10378508 82 -      
ENSG00000105397 E055 132.0158215 0.0071396230 2.814964e-04 1.304581e-03 19 10379615 10379689 75 - 2.190 2.020 -0.570
ENSG00000105397 E056 151.3969020 0.0014322665 8.291303e-08 8.556749e-07 19 10379690 10379779 90 - 2.250 2.078 -0.576
ENSG00000105397 E057 138.6659836 0.0002459292 1.333657e-06 1.078258e-05 19 10380380 10380509 130 - 2.192 2.051 -0.473
ENSG00000105397 E058 33.4567925 0.0006013036 4.189759e-02 9.453755e-02 19 10380510 10380590 81 - 1.571 1.454 -0.399