ENSG00000105376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221980 ENSG00000105376 HEK293_OSMI2_2hA HEK293_TMG_2hB ICAM5 protein_coding protein_coding 5.656665 4.9676 4.824947 0.6249705 0.4275131 -0.04195038 0.4547948 0.8826926 0.05237826 0.16849819 0.05237826 -3.8390483 0.08840417 0.19063333 0.009233333 -0.18140000 0.00565538 0.00565538 FALSE TRUE
ENST00000586480 ENSG00000105376 HEK293_OSMI2_2hA HEK293_TMG_2hB ICAM5 protein_coding retained_intron 5.656665 4.9676 4.824947 0.6249705 0.4275131 -0.04195038 0.5475515 0.3142576 0.78771942 0.31425761 0.16966756 1.2987410 0.09146667 0.05066667 0.166166667 0.11550000 0.20492278 0.00565538 FALSE TRUE
ENST00000587398 ENSG00000105376 HEK293_OSMI2_2hA HEK293_TMG_2hB ICAM5 protein_coding protein_coding 5.656665 4.9676 4.824947 0.6249705 0.4275131 -0.04195038 0.8355286 0.6371080 0.44334619 0.24983261 0.09629879 -0.5133933 0.13535417 0.12310000 0.089933333 -0.03316667 0.78801758 0.00565538 FALSE FALSE
ENST00000588912 ENSG00000105376 HEK293_OSMI2_2hA HEK293_TMG_2hB ICAM5 protein_coding retained_intron 5.656665 4.9676 4.824947 0.6249705 0.4275131 -0.04195038 1.1331934 0.7651878 1.21642530 0.04964499 0.16475872 0.6618416 0.20177917 0.15893333 0.251633333 0.09270000 0.17778162 0.00565538 FALSE TRUE
MSTRG.16403.1 ENSG00000105376 HEK293_OSMI2_2hA HEK293_TMG_2hB ICAM5 protein_coding   5.656665 4.9676 4.824947 0.6249705 0.4275131 -0.04195038 0.3585838 0.1121864 0.32275123 0.11218644 0.18434855 1.4453599 0.05878333 0.02480000 0.072800000 0.04800000 0.62678267 0.00565538 FALSE TRUE
MSTRG.16403.3 ENSG00000105376 HEK293_OSMI2_2hA HEK293_TMG_2hB ICAM5 protein_coding   5.656665 4.9676 4.824947 0.6249705 0.4275131 -0.04195038 2.3145694 2.2561680 2.00232645 0.33266568 0.32452119 -0.1713905 0.42208333 0.45183333 0.410233333 -0.04160000 0.73601976 0.00565538 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105376 E001 2.693722 0.0511480534 0.0326011054 0.07700302 19 10289406 10289461 56 + 0.762 0.385 -1.744
ENSG00000105376 E002 1.611558 0.0215499073 0.1126397051 0.20940341 19 10289934 10289951 18 + 0.553 0.271 -1.569
ENSG00000105376 E003 2.512130 0.0388355316 0.0704177484 0.14404491 19 10289952 10289992 41 + 0.703 0.387 -1.489
ENSG00000105376 E004 3.859280 0.1374338780 0.0972816924 0.18633388 19 10289993 10290023 31 + 0.860 0.516 -1.453
ENSG00000105376 E005 7.980647 0.0026018104 0.0390670799 0.08932319 19 10290024 10290125 102 + 1.067 0.830 -0.885
ENSG00000105376 E006 20.883858 0.0011128359 0.0006309512 0.00264693 19 10290126 10290920 795 + 1.467 1.212 -0.889
ENSG00000105376 E007 5.115514 0.0036611311 0.9278863607 0.95860575 19 10290977 10291071 95 + 0.788 0.771 -0.070
ENSG00000105376 E008 13.540855 0.0016568809 0.0174866852 0.04601559 19 10291072 10291316 245 + 1.008 1.227 0.787
ENSG00000105376 E009 7.539734 0.0023515796 0.0116292970 0.03265017 19 10291317 10291341 25 + 0.703 1.010 1.191
ENSG00000105376 E010 0.810555 0.0153787590 0.1056520444 0.19908950 19 10291473 10291488 16 + 0.393 0.110 -2.349
ENSG00000105376 E011 32.370582 0.0007144416 0.7774906455 0.85680953 19 10291489 10291809 321 + 1.518 1.495 -0.078
ENSG00000105376 E012 41.175645 0.0023710062 0.0198046487 0.05106961 19 10292035 10292322 288 + 1.685 1.549 -0.462
ENSG00000105376 E013 47.997513 0.0205623828 0.4358015397 0.57797414 19 10292612 10292866 255 + 1.711 1.649 -0.211
ENSG00000105376 E014 48.549219 0.0006018409 0.5008089813 0.63702612 19 10292998 10293246 249 + 1.701 1.663 -0.130
ENSG00000105376 E015 47.861205 0.0047851720 0.0740285907 0.14996412 19 10293698 10293943 246 + 1.609 1.711 0.344
ENSG00000105376 E016 48.723100 0.0005667172 0.0041694816 0.01361913 19 10294040 10294318 279 + 1.593 1.731 0.466
ENSG00000105376 E017 39.636627 0.0006163284 0.8979177438 0.93884189 19 10294401 10294640 240 + 1.602 1.589 -0.044
ENSG00000105376 E018 39.392368 0.0005865596 0.0497528285 0.10872050 19 10295346 10295612 267 + 1.523 1.626 0.351
ENSG00000105376 E019 19.790265 0.0011490553 0.5229156587 0.65665842 19 10295613 10295752 140 + 1.270 1.314 0.153
ENSG00000105376 E020 20.866374 0.0010968586 0.1390968207 0.24682608 19 10296339 10296778 440 + 1.253 1.360 0.375