ENSG00000105364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253099 ENSG00000105364 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL4 protein_coding protein_coding 249.0695 469.9109 136.7263 27.78566 3.77407 -1.781021 186.98329 370.18187 95.833113 23.899049 3.9500696 -1.949527 0.73241250 0.78743333 0.70043333 -0.08700000 0.0009425456 1.829864e-09 FALSE  
ENST00000590669 ENSG00000105364 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL4 protein_coding protein_coding 249.0695 469.9109 136.7263 27.78566 3.77407 -1.781021 18.87036 31.87608 10.449619 3.954104 0.9730409 -1.608096 0.07665417 0.06753333 0.07623333 0.00870000 0.7236537945 1.829864e-09 FALSE  
ENST00000590702 ENSG00000105364 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL4 protein_coding protein_coding 249.0695 469.9109 136.7263 27.78566 3.77407 -1.781021 11.71965 18.88111 7.672186 1.378821 0.7494815 -1.298119 0.05381667 0.04046667 0.05590000 0.01543333 0.1688865343 1.829864e-09 FALSE  
MSTRG.16398.1 ENSG00000105364 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL4 protein_coding   249.0695 469.9109 136.7263 27.78566 3.77407 -1.781021 12.24408 18.24206 8.760969 2.579547 0.1080622 -1.057251 0.05345833 0.03850000 0.06413333 0.02563333 0.0048978856 1.829864e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105364 E001 0.4031496 0.0244093249 1.000000e+00 1.000000e+00 19 10251784 10251900 117 + 0.001 0.128 8.114
ENSG00000105364 E002 3.3494442 0.0047012486 5.536987e-01 6.828003e-01 19 10251901 10251943 43 + 0.455 0.574 0.570
ENSG00000105364 E003 19.6748288 0.0265736794 2.598500e-03 9.060783e-03 19 10251944 10251963 20 + 1.440 1.124 -1.110
ENSG00000105364 E004 46.7074240 0.0033062370 7.107290e-07 6.094761e-06 19 10251964 10251978 15 + 1.784 1.492 -0.994
ENSG00000105364 E005 75.7833621 0.0128129180 1.516692e-04 7.544463e-04 19 10251979 10251990 12 + 1.963 1.715 -0.835
ENSG00000105364 E006 104.8486481 0.0009525814 6.114112e-11 1.116004e-09 19 10251991 10251997 7 + 2.103 1.851 -0.849
ENSG00000105364 E007 138.4677970 0.0055787067 4.031616e-07 3.633057e-06 19 10251998 10252009 12 + 2.213 1.980 -0.780
ENSG00000105364 E008 336.5789834 0.0076048311 5.319266e-05 2.977189e-04 19 10252010 10252145 136 + 2.556 2.381 -0.583
ENSG00000105364 E009 304.0419679 0.0067720040 2.007637e-04 9.670577e-04 19 10252146 10252213 68 + 2.493 2.342 -0.504
ENSG00000105364 E010 215.6255670 0.0133982549 1.100431e-03 4.304606e-03 19 10252214 10252226 13 + 2.364 2.187 -0.592
ENSG00000105364 E011 576.4525814 0.0114183732 8.252232e-02 1.634877e-01 19 10252227 10252257 31 + 2.705 2.639 -0.218
ENSG00000105364 E012 666.1891238 0.0102371924 1.303901e-01 2.347073e-01 19 10252258 10252275 18 + 2.754 2.706 -0.162
ENSG00000105364 E013 908.3510678 0.0094453150 2.469908e-01 3.823974e-01 19 10252276 10252304 29 + 2.871 2.845 -0.088
ENSG00000105364 E014 862.3480740 0.0086800485 4.351172e-01 5.773535e-01 19 10252305 10252310 6 + 2.833 2.826 -0.025
ENSG00000105364 E015 19.1600068 0.0038971286 6.609888e-01 7.695622e-01 19 10252311 10252363 53 + 1.145 1.204 0.210
ENSG00000105364 E016 19.8867901 0.0015110813 2.901211e-01 4.309100e-01 19 10252364 10252396 33 + 1.276 1.193 -0.292
ENSG00000105364 E017 1286.8037548 0.0052785520 1.554446e-01 2.689902e-01 19 10252397 10252463 67 + 3.023 2.996 -0.089
ENSG00000105364 E018 6.3896558 0.0536813559 5.865597e-01 7.101118e-01 19 10252464 10252550 87 + 0.672 0.792 0.490
ENSG00000105364 E019 2070.2629508 0.0026831227 1.038516e-01 1.963765e-01 19 10252551 10252701 151 + 3.222 3.204 -0.061
ENSG00000105364 E020 14.8929374 0.0418209392 2.926720e-02 7.051843e-02 19 10252702 10253029 328 + 1.304 1.026 -0.992
ENSG00000105364 E021 1316.3136938 0.0011063721 1.013635e-02 2.909987e-02 19 10254589 10254619 31 + 3.034 3.003 -0.100
ENSG00000105364 E022 1164.9467978 0.0003299840 1.569010e-02 4.204126e-02 19 10254620 10254640 21 + 2.970 2.950 -0.065
ENSG00000105364 E023 13.3065539 0.0013219432 1.223861e-18 6.681753e-17 19 10254641 10255717 1077 + 1.551 0.764 -2.845
ENSG00000105364 E024 2082.2547566 0.0004316677 1.395020e-01 2.473419e-01 19 10256708 10256825 118 + 3.177 3.216 0.127
ENSG00000105364 E025 943.4197099 0.0020210428 1.733618e-03 6.388670e-03 19 10258222 10258224 3 + 2.782 2.884 0.339
ENSG00000105364 E026 2205.5047827 0.0020061216 1.071921e-02 3.049794e-02 19 10258225 10258328 104 + 3.171 3.249 0.260
ENSG00000105364 E027 2568.5755232 0.0020484056 5.181219e-02 1.123871e-01 19 10258413 10258522 110 + 3.250 3.313 0.209
ENSG00000105364 E028 113.4787678 0.0009841640 2.829754e-05 1.693213e-04 19 10258523 10258608 86 + 2.070 1.915 -0.523
ENSG00000105364 E029 2108.5151365 0.0026865275 1.077015e-02 3.061599e-02 19 10258609 10258685 77 + 3.145 3.231 0.284
ENSG00000105364 E030 507.8191241 0.0018906821 7.217637e-01 8.160175e-01 19 10258686 10259125 440 + 2.592 2.599 0.023
ENSG00000105364 E031 425.7757081 0.0017467452 9.835756e-01 9.937943e-01 19 10259172 10259616 445 + 2.508 2.525 0.055
ENSG00000105364 E032 3693.7455478 0.0033344510 3.334861e-04 1.514260e-03 19 10259617 10260055 439 + 3.365 3.479 0.377