ENSG00000105355

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221957 ENSG00000105355 HEK293_OSMI2_2hA HEK293_TMG_2hB PLIN3 protein_coding protein_coding 32.20934 60.6351 17.32678 2.753109 0.49777 -1.806555 30.366475 58.236938 14.727868 2.4239592 0.4048578 -1.982654 0.92663333 0.9608667 0.85006667 -0.11080000 1.570512e-08 1.570512e-08 FALSE TRUE
ENST00000585479 ENSG00000105355 HEK293_OSMI2_2hA HEK293_TMG_2hB PLIN3 protein_coding protein_coding 32.20934 60.6351 17.32678 2.753109 0.49777 -1.806555 1.084535 1.110013 1.347321 0.1525454 0.7139033 0.277246 0.04632917 0.0182000 0.07916667 0.06096667 8.029907e-01 1.570512e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105355 E001 48.7692670 0.0025041267 1.378968e-02 3.774837e-02 19 4838341 4838368 28 - 1.419 1.600 0.622
ENSG00000105355 E002 49.4292621 0.0032080485 1.197707e-02 3.347674e-02 19 4838369 4838370 2 - 1.419 1.607 0.644
ENSG00000105355 E003 233.1004245 0.0027567334 5.548741e-05 3.091015e-04 19 4838371 4838503 133 - 2.100 2.266 0.555
ENSG00000105355 E004 470.2145006 0.0015684938 4.476855e-06 3.222733e-05 19 4838504 4838829 326 - 2.433 2.564 0.437
ENSG00000105355 E005 508.9571921 0.0001729099 2.902214e-06 2.178696e-05 19 4838830 4839061 232 - 2.495 2.593 0.327
ENSG00000105355 E006 805.8676670 0.0001844232 8.787923e-02 1.718979e-01 19 4839062 4839533 472 - 2.755 2.781 0.088
ENSG00000105355 E007 136.6047681 0.0003624918 5.879228e-01 7.111676e-01 19 4839534 4839536 3 - 1.994 2.014 0.067
ENSG00000105355 E008 326.4253569 0.0012280157 5.109927e-01 6.461188e-01 19 4844668 4844793 126 - 2.371 2.390 0.064
ENSG00000105355 E009 285.6983638 0.0002291840 9.404968e-01 9.666297e-01 19 4847691 4847816 126 - 2.328 2.329 0.002
ENSG00000105355 E010 253.6831330 0.0001787290 3.354352e-01 4.792216e-01 19 4847817 4847890 74 - 2.299 2.270 -0.096
ENSG00000105355 E011 185.2984046 0.0001959437 2.682354e-01 4.066775e-01 19 4852016 4852038 23 - 2.171 2.133 -0.127
ENSG00000105355 E012 417.6339701 0.0008937135 9.621282e-04 3.828928e-03 19 4852039 4852207 169 - 2.557 2.475 -0.274
ENSG00000105355 E013 275.1013980 0.0011626229 3.583642e-04 1.612499e-03 19 4852208 4852265 58 - 2.397 2.289 -0.360
ENSG00000105355 E014 221.2478892 0.0001872141 2.192810e-02 5.552498e-02 19 4852266 4852301 36 - 2.273 2.203 -0.233
ENSG00000105355 E015 323.0362353 0.0023163079 7.396056e-02 1.498519e-01 19 4859590 4859672 83 - 2.428 2.369 -0.196
ENSG00000105355 E016 420.3195678 0.0013760365 1.961597e-02 5.066375e-02 19 4859826 4859983 158 - 2.544 2.482 -0.208
ENSG00000105355 E017 227.7914431 0.0024461259 4.807644e-02 1.057636e-01 19 4859984 4860024 41 - 2.287 2.214 -0.242
ENSG00000105355 E018 0.0000000       19 4860452 4860495 44 -      
ENSG00000105355 E019 256.2299417 0.0015842417 8.456694e-02 1.667026e-01 19 4861329 4861411 83 - 2.325 2.268 -0.190
ENSG00000105355 E020 0.4751703 0.0205958376 5.490231e-01 6.787930e-01 19 4866633 4866879 247 - 0.221 0.120 -1.059
ENSG00000105355 E021 0.1817044 0.0398635411 1.000000e+00   19 4866880 4866994 115 - 0.000 0.064 7.306
ENSG00000105355 E022 0.1817044 0.0398635411 1.000000e+00   19 4866995 4867112 118 - 0.000 0.064 7.306
ENSG00000105355 E023 167.6867411 0.0003684061 2.446569e-01 3.796433e-01 19 4867609 4867713 105 - 2.131 2.089 -0.141