ENSG00000105323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392006 ENSG00000105323 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPUL1 protein_coding protein_coding 164.4977 192.1718 175.5138 18.80291 4.755822 -0.1308046 63.017922 77.927172 61.571208 14.788430 2.7398090 -0.3398214 0.37535833 0.39896667 0.35120000 -0.047766667 0.7308506986 5.273181e-08 FALSE TRUE
ENST00000595018 ENSG00000105323 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPUL1 protein_coding protein_coding 164.4977 192.1718 175.5138 18.80291 4.755822 -0.1308046 22.758246 45.058639 13.358180 8.650313 2.1080629 -1.7533209 0.13952500 0.24703333 0.07586667 -0.171166667 0.0212542494 5.273181e-08 FALSE TRUE
ENST00000595196 ENSG00000105323 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPUL1 protein_coding nonsense_mediated_decay 164.4977 192.1718 175.5138 18.80291 4.755822 -0.1308046 7.030719 12.155424 2.204792 1.031932 0.6809725 -2.4575434 0.04132083 0.06380000 0.01280000 -0.051000000 0.0001207418 5.273181e-08 FALSE TRUE
ENST00000599719 ENSG00000105323 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPUL1 protein_coding protein_coding 164.4977 192.1718 175.5138 18.80291 4.755822 -0.1308046 24.337850 12.830944 41.393301 4.169141 3.1246122 1.6889945 0.15175000 0.06403333 0.23720000 0.173166667 0.0009571620 5.273181e-08 FALSE TRUE
ENST00000600596 ENSG00000105323 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPUL1 protein_coding nonsense_mediated_decay 164.4977 192.1718 175.5138 18.80291 4.755822 -0.1308046 11.332303 7.402154 18.348287 3.595223 2.3559645 1.3084666 0.07107500 0.03583333 0.10396667 0.068133333 0.0278567009 5.273181e-08 FALSE FALSE
MSTRG.17202.8 ENSG00000105323 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPUL1 protein_coding   164.4977 192.1718 175.5138 18.80291 4.755822 -0.1308046 11.575227 13.845369 12.886632 1.365646 0.2959020 -0.1034508 0.07008333 0.07203333 0.07360000 0.001566667 0.9478056592 5.273181e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105323 E001 2.4221278 6.134196e-02 3.055591e-03 1.043014e-02 19 41262496 41262518 23 + 0.783 0.258 -2.637
ENSG00000105323 E002 2.7908220 1.673948e-02 1.540669e-03 5.768001e-03 19 41262519 41262520 2 + 0.810 0.320 -2.327
ENSG00000105323 E003 4.6330877 4.137944e-03 3.008843e-03 1.029208e-02 19 41262521 41262529 9 + 0.944 0.570 -1.522
ENSG00000105323 E004 73.2051794 3.985609e-03 1.818594e-06 1.427855e-05 19 41262530 41262582 53 + 1.976 1.764 -0.711
ENSG00000105323 E005 0.1817044 3.933083e-02 7.160126e-01   19 41262662 41262670 9 + 0.000 0.104 9.958
ENSG00000105323 E006 17.3254948 1.071901e-03 4.111903e-01 5.547713e-01 19 41262671 41262981 311 + 1.177 1.277 0.354
ENSG00000105323 E007 4.3262038 7.257885e-02 8.929131e-01 9.355661e-01 19 41262982 41263016 35 + 0.691 0.743 0.213
ENSG00000105323 E008 93.1054522 3.104319e-04 6.087892e-07 5.296592e-06 19 41264138 41264371 234 + 2.048 1.894 -0.516
ENSG00000105323 E009 83.3728354 1.457089e-02 6.595518e-02 1.366277e-01 19 41264372 41264410 39 + 1.963 1.876 -0.293
ENSG00000105323 E010 98.2811594 2.712828e-02 1.574451e-01 2.717074e-01 19 41264411 41264421 11 + 2.027 1.951 -0.256
ENSG00000105323 E011 111.7516266 2.238777e-02 2.191096e-02 5.549271e-02 19 41264422 41264426 5 + 2.117 1.980 -0.458
ENSG00000105323 E012 138.5211502 1.613485e-02 1.303829e-02 3.600047e-02 19 41264427 41264433 7 + 2.206 2.076 -0.434
ENSG00000105323 E013 229.7088356 1.672000e-02 1.383631e-01 2.458226e-01 19 41264434 41264450 17 + 2.380 2.325 -0.184
ENSG00000105323 E014 652.9066369 1.746255e-02 2.735861e-02 6.672424e-02 19 41264451 41264605 155 + 2.859 2.760 -0.327
ENSG00000105323 E015 668.9658722 1.446281e-02 1.335910e-02 3.675556e-02 19 41264606 41264692 87 + 2.872 2.768 -0.346
ENSG00000105323 E016 414.7887788 1.939916e-02 2.266286e-02 5.705301e-02 19 41264693 41264734 42 + 2.670 2.557 -0.374
ENSG00000105323 E017 451.0201040 1.292752e-02 1.939251e-02 5.018309e-02 19 41264735 41264798 64 + 2.694 2.602 -0.308
ENSG00000105323 E018 15.7159734 1.153242e-03 2.805807e-02 6.812930e-02 19 41264847 41265078 232 + 1.303 1.147 -0.551
ENSG00000105323 E019 18.2548531 1.803360e-03 6.340238e-02 1.323628e-01 19 41265079 41265100 22 + 1.343 1.224 -0.419
ENSG00000105323 E020 32.5708882 8.214703e-03 4.587092e-01 5.990080e-01 19 41265101 41265121 21 + 1.523 1.499 -0.085
ENSG00000105323 E021 1.7005031 1.351230e-02 1.987338e-01 3.246040e-01 19 41265122 41265167 46 + 0.524 0.320 -1.103
ENSG00000105323 E022 18.6823358 2.268432e-03 3.241157e-01 4.674849e-01 19 41265168 41265343 176 + 1.303 1.252 -0.180
ENSG00000105323 E023 7.0461140 2.291815e-03 1.370972e-03 5.211730e-03 19 41268078 41268222 145 + 1.076 0.728 -1.328
ENSG00000105323 E024 994.5938230 1.339496e-03 1.334238e-12 3.205268e-11 19 41268223 41268298 76 + 3.049 2.935 -0.381
ENSG00000105323 E025 1109.2492772 3.987044e-04 1.331498e-21 1.016311e-19 19 41268299 41268345 47 + 3.090 2.986 -0.345
ENSG00000105323 E026 1036.8883987 3.618416e-04 2.925668e-20 1.925848e-18 19 41272082 41272117 36 + 3.058 2.959 -0.330
ENSG00000105323 E027 1691.3074151 2.580111e-04 3.370801e-16 1.356389e-14 19 41272118 41272235 118 + 3.248 3.188 -0.201
ENSG00000105323 E028 3.6396904 4.279277e-03 4.737732e-01 6.126741e-01 19 41272236 41272370 135 + 0.572 0.705 0.578
ENSG00000105323 E029 1133.7167716 2.128986e-04 7.288310e-04 3.002541e-03 19 41273982 41274032 51 + 3.044 3.033 -0.035
ENSG00000105323 E030 941.2560881 4.366733e-04 5.072899e-04 2.187525e-03 19 41274033 41274055 23 + 2.970 2.949 -0.069
ENSG00000105323 E031 1566.1438031 9.141514e-04 6.506305e-04 2.718091e-03 19 41276159 41276269 111 + 3.193 3.169 -0.079
ENSG00000105323 E032 1006.2331172 7.967804e-04 2.185685e-02 5.538233e-02 19 41276270 41276298 29 + 2.990 2.983 -0.025
ENSG00000105323 E033 0.8147328 9.991948e-02 9.715793e-01 9.862391e-01 19 41276299 41276808 510 + 0.251 0.258 0.057
ENSG00000105323 E034 0.1472490 4.332619e-02 3.237926e-01   19 41278339 41278443 105 + 0.143 0.000 -11.156
ENSG00000105323 E035 1484.6813494 6.155652e-04 9.998816e-05 5.217877e-04 19 41279077 41279176 100 + 3.170 3.145 -0.083
ENSG00000105323 E036 3.7823263 1.509645e-02 3.014335e-02 7.224907e-02 19 41280925 41281162 238 + 0.836 0.537 -1.262
ENSG00000105323 E037 1609.6153743 7.307167e-04 7.019150e-06 4.833546e-05 19 41281163 41281275 113 + 3.212 3.176 -0.120
ENSG00000105323 E038 0.1451727 4.305769e-02 3.242130e-01   19 41291879 41291884 6 + 0.143 0.000 -11.159
ENSG00000105323 E039 2967.5177113 3.634445e-04 6.368071e-09 8.151432e-08 19 41292245 41292511 267 + 3.474 3.444 -0.097
ENSG00000105323 E040 1622.3059406 7.154179e-05 1.425712e-01 2.515384e-01 19 41294338 41294460 123 + 3.181 3.199 0.060
ENSG00000105323 E041 1799.3502068 2.372882e-04 6.562769e-01 7.659354e-01 19 41294558 41294686 129 + 3.219 3.247 0.092
ENSG00000105323 E042 3.2087439 1.672025e-02 2.659127e-01 4.040226e-01 19 41298490 41298909 420 + 0.690 0.538 -0.668
ENSG00000105323 E043 2456.1785603 4.360201e-05 5.147884e-01 6.495136e-01 19 41301536 41301704 169 + 3.356 3.383 0.090
ENSG00000105323 E044 11.8564202 5.131970e-03 1.180543e-02 3.306970e-02 19 41302393 41302664 272 + 1.220 0.999 -0.798
ENSG00000105323 E045 2644.0146238 4.321830e-05 1.979619e-04 9.550844e-04 19 41302665 41302949 285 + 3.366 3.426 0.200
ENSG00000105323 E046 1703.7246059 1.158246e-03 9.540639e-07 7.947260e-06 19 41303972 41304261 290 + 3.133 3.257 0.413
ENSG00000105323 E047 80.9330317 3.532709e-04 4.603377e-02 1.020986e-01 19 41305646 41305675 30 + 1.823 1.937 0.385
ENSG00000105323 E048 494.5882305 3.219049e-03 4.116730e-04 1.819183e-03 19 41305676 41305680 5 + 2.579 2.728 0.497
ENSG00000105323 E049 943.8525138 2.272466e-03 1.888038e-09 2.656984e-08 19 41305681 41305831 151 + 2.828 3.020 0.639
ENSG00000105323 E050 507.2666436 4.888780e-03 1.362656e-06 1.099311e-05 19 41305832 41305867 36 + 2.538 2.758 0.734
ENSG00000105323 E051 6250.0316853 5.842060e-03 7.490751e-11 1.347930e-09 19 41306449 41308826 2378 + 3.607 3.855 0.821