ENSG00000105321

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221922 ENSG00000105321 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC9 protein_coding protein_coding 13.6951 20.74677 8.414396 0.8560458 0.2064801 -1.300937 4.0479297 7.575577 1.721526 0.06240870 0.2021290 -2.1312148 0.27021250 0.36670000 0.2048667 -0.16183333 0.001990292 6.423994e-05 FALSE TRUE
ENST00000595659 ENSG00000105321 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC9 protein_coding protein_coding 13.6951 20.74677 8.414396 0.8560458 0.2064801 -1.300937 1.3060018 1.555618 1.167164 0.17991093 0.3086962 -0.4114168 0.10545833 0.07583333 0.1370667 0.06123333 0.381419097 6.423994e-05   FALSE
ENST00000599398 ENSG00000105321 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC9 protein_coding protein_coding 13.6951 20.74677 8.414396 0.8560458 0.2064801 -1.300937 0.8715558 1.154011 0.426386 0.05712179 0.0530006 -1.4154274 0.06719167 0.05580000 0.0509000 -0.00490000 0.897875080 6.423994e-05 FALSE FALSE
MSTRG.17395.2 ENSG00000105321 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC9 protein_coding   13.6951 20.74677 8.414396 0.8560458 0.2064801 -1.300937 5.4706377 8.146016 4.267324 0.59614742 0.2882304 -0.9311562 0.41134167 0.39160000 0.5090667 0.11746667 0.184249372 6.423994e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105321 E001 1.7057250 0.0375377978 0.725395308 0.818672271 19 47255980 47256358 379 + 0.431 0.364 -0.371
ENSG00000105321 E002 0.5514428 0.0196886745 0.431697477 0.574235662 19 47256388 47256522 135 + 0.000 0.194 9.053
ENSG00000105321 E003 1.1812489 0.0106437269 0.499296849 0.635614817 19 47256523 47256524 2 + 0.195 0.327 0.992
ENSG00000105321 E004 51.6881879 0.0005653606 0.017027075 0.044994884 19 47256525 47256609 85 + 1.729 1.600 -0.436
ENSG00000105321 E005 2.9095750 0.0997841278 0.868962026 0.919790416 19 47257532 47257539 8 + 0.513 0.552 0.182
ENSG00000105321 E006 8.7311917 0.0148936315 0.778401261 0.857410012 19 47257540 47257654 115 + 0.950 0.917 -0.124
ENSG00000105321 E007 10.7681197 0.0016851544 0.920208817 0.953591334 19 47257655 47257909 255 + 1.002 0.992 -0.037
ENSG00000105321 E008 1.5134115 0.0092711593 0.572468013 0.698592694 19 47258089 47258329 241 + 0.431 0.327 -0.592
ENSG00000105321 E009 86.5832955 0.0003284868 0.001246038 0.004796673 19 47258330 47258403 74 + 1.956 1.822 -0.448
ENSG00000105321 E010 115.4827706 0.0002632358 0.017257365 0.045518990 19 47258559 47258663 105 + 2.044 1.958 -0.287
ENSG00000105321 E011 112.4323568 0.0002821161 0.213639508 0.342820120 19 47260321 47260422 102 + 2.002 1.956 -0.152
ENSG00000105321 E012 117.6808289 0.0028888404 0.430623436 0.573228002 19 47260588 47260839 252 + 1.955 1.994 0.128
ENSG00000105321 E013 69.2887181 0.0082473210 0.469870890 0.609101175 19 47264603 47264686 84 + 1.788 1.747 -0.139
ENSG00000105321 E014 94.0282704 0.0107082194 0.787462048 0.863888553 19 47264773 47264946 174 + 1.900 1.887 -0.043
ENSG00000105321 E015 5.7402342 0.0282881232 0.195195417 0.320238202 19 47266295 47266610 316 + 0.891 0.697 -0.771
ENSG00000105321 E016 105.5004424 0.0004274938 0.574273843 0.700124567 19 47266611 47266792 182 + 1.919 1.943 0.082
ENSG00000105321 E017 69.5592535 0.0003620968 0.200289778 0.326578622 19 47270407 47270453 47 + 1.710 1.776 0.223
ENSG00000105321 E018 111.6879352 0.0023859228 0.547962394 0.677897487 19 47270553 47270688 136 + 1.944 1.974 0.098
ENSG00000105321 E019 117.6830852 0.0033693795 0.139633289 0.247521407 19 47271082 47271187 106 + 1.933 2.005 0.243
ENSG00000105321 E020 154.6524717 0.0008319948 0.002900634 0.009970904 19 47271274 47271403 130 + 2.019 2.128 0.365
ENSG00000105321 E021 188.1361300 0.0002834719 0.001412399 0.005347965 19 47271404 47271649 246 + 2.111 2.211 0.333
ENSG00000105321 E022 39.6632747 0.0072424986 0.012899583 0.035679372 19 47271650 47271953 304 + 1.362 1.568 0.706
ENSG00000105321 E023 62.8403243 0.0020820417 0.033268898 0.078327406 19 47272069 47272161 93 + 1.804 1.694 -0.374
ENSG00000105321 E024 53.8911680 0.0006536467 0.172339867 0.291248703 19 47273357 47273406 50 + 1.710 1.637 -0.247
ENSG00000105321 E025 8.6208315 0.0176098941 0.007101342 0.021491548 19 47273407 47273701 295 + 0.513 0.960 1.846
ENSG00000105321 E026 77.8984417 0.0004928707 0.009219087 0.026832514 19 47273966 47274313 348 + 1.901 1.787 -0.384