ENSG00000105298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000429344 ENSG00000105298 HEK293_OSMI2_2hA HEK293_TMG_2hB CACTIN protein_coding protein_coding 28.26476 43.89098 18.77825 3.23083 0.1842186 -1.224423 20.205326 32.1821273 14.140435 2.3061901 0.35571114 -1.1858615 0.70487083 0.73350000 0.75320000 0.01970000 7.794401e-01 2.445931e-16 FALSE TRUE
ENST00000587175 ENSG00000105298 HEK293_OSMI2_2hA HEK293_TMG_2hB CACTIN protein_coding retained_intron 28.26476 43.89098 18.77825 3.23083 0.1842186 -1.224423 1.466182 1.7720001 1.012450 0.2603055 0.14718908 -0.8014667 0.05654583 0.04033333 0.05406667 0.01373333 5.582231e-01 2.445931e-16 FALSE TRUE
ENST00000591978 ENSG00000105298 HEK293_OSMI2_2hA HEK293_TMG_2hB CACTIN protein_coding retained_intron 28.26476 43.89098 18.77825 3.23083 0.1842186 -1.224423 1.484316 1.2047176 1.372880 0.1910066 0.09422308 0.1870545 0.06066667 0.02720000 0.07303333 0.04583333 8.629613e-06 2.445931e-16 FALSE FALSE
ENST00000592721 ENSG00000105298 HEK293_OSMI2_2hA HEK293_TMG_2hB CACTIN protein_coding protein_coding 28.26476 43.89098 18.77825 3.23083 0.1842186 -1.224423 2.199655 5.1811947 0.000000 0.7158281 0.00000000 -9.0199228 0.05837083 0.12140000 0.00000000 -0.12140000 2.445931e-16 2.445931e-16 FALSE TRUE
MSTRG.16167.8 ENSG00000105298 HEK293_OSMI2_2hA HEK293_TMG_2hB CACTIN protein_coding   28.26476 43.89098 18.77825 3.23083 0.1842186 -1.224423 1.322120 0.2943923 2.228076 0.2943923 0.49329801 2.8782553 0.06082083 0.00650000 0.11836667 0.11186667 1.975850e-02 2.445931e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105298 E001 2.246457 0.0067153654 6.840241e-02 1.407262e-01 19 3610645 3610646 2 - 0.183 0.536 2.220
ENSG00000105298 E002 2.246457 0.0067153654 6.840241e-02 1.407262e-01 19 3610647 3610649 3 - 0.182 0.536 2.223
ENSG00000105298 E003 2.939863 0.0055594015 2.061487e-02 5.277674e-02 19 3610650 3610659 10 - 0.182 0.628 2.638
ENSG00000105298 E004 45.864687 0.0004786274 4.785291e-02 1.053613e-01 19 3610660 3610704 45 - 1.509 1.630 0.412
ENSG00000105298 E005 313.348085 0.0055617399 3.374890e-04 1.530308e-03 19 3610705 3610966 262 - 2.307 2.465 0.525
ENSG00000105298 E006 130.815717 0.0047743032 1.994808e-02 5.137771e-02 19 3610967 3610971 5 - 1.963 2.080 0.395
ENSG00000105298 E007 212.728009 0.0038477489 1.414133e-02 3.854722e-02 19 3610972 3611061 90 - 2.184 2.287 0.344
ENSG00000105298 E008 286.459394 0.0023081981 1.776513e-05 1.114605e-04 19 3611062 3611228 167 - 2.276 2.423 0.490
ENSG00000105298 E009 263.479126 0.0009232057 1.725091e-04 8.459700e-04 19 3611229 3611360 132 - 2.266 2.377 0.369
ENSG00000105298 E010 128.204587 0.0020720038 2.003785e-03 7.237716e-03 19 3611361 3611364 4 - 1.935 2.069 0.453
ENSG00000105298 E011 343.202643 0.0025465941 7.560437e-03 2.267162e-02 19 3611365 3611567 203 - 2.398 2.488 0.298
ENSG00000105298 E012 461.282380 0.0005714171 1.978442e-03 7.159829e-03 19 3611568 3611899 332 - 2.542 2.609 0.225
ENSG00000105298 E013 132.627166 0.0003156739 2.873939e-01 4.278892e-01 19 3611900 3611903 4 - 2.025 2.062 0.126
ENSG00000105298 E014 697.020915 0.0001023736 2.561580e-01 3.931204e-01 19 3611904 3612413 510 - 2.760 2.777 0.056
ENSG00000105298 E015 235.442546 0.0010155417 8.223514e-02 1.630323e-01 19 3613058 3613365 308 - 2.341 2.290 -0.167
ENSG00000105298 E016 79.406565 0.0029223634 4.479004e-01 5.892522e-01 19 3613464 3613506 43 - 1.866 1.828 -0.128
ENSG00000105298 E017 114.559521 0.0013409380 8.534225e-01 9.092870e-01 19 3613507 3613586 80 - 1.987 1.995 0.026
ENSG00000105298 E018 12.982896 0.0785276567 5.838161e-01 7.078496e-01 19 3614386 3614396 11 - 1.165 1.054 -0.400
ENSG00000105298 E019 69.393558 0.0005759073 8.111101e-01 8.801741e-01 19 3614397 3614409 13 - 1.785 1.773 -0.041
ENSG00000105298 E020 167.051083 0.0002083849 8.633050e-01 9.158237e-01 19 3614410 3614494 85 - 2.158 2.152 -0.019
ENSG00000105298 E021 205.962704 0.0002827027 1.689141e-01 2.867656e-01 19 3614495 3614589 95 - 2.272 2.233 -0.130
ENSG00000105298 E022 75.361622 0.0038286196 4.094486e-15 1.426159e-13 19 3614590 3616692 2103 - 2.072 1.678 -1.326
ENSG00000105298 E023 246.319144 0.0008956600 8.905466e-04 3.581070e-03 19 3618875 3618989 115 - 2.391 2.299 -0.307
ENSG00000105298 E024 261.174127 0.0005035540 8.125248e-03 2.410096e-02 19 3619080 3619242 163 - 2.399 2.331 -0.227
ENSG00000105298 E025 269.051691 0.0003416424 1.281260e-02 3.547246e-02 19 3620127 3620272 146 - 2.408 2.347 -0.206
ENSG00000105298 E026 227.795553 0.0002243367 5.510696e-04 2.350788e-03 19 3620707 3620802 96 - 2.356 2.266 -0.301
ENSG00000105298 E027 21.441050 0.0025444264 9.295518e-01 9.596408e-01 19 3620803 3621028 226 - 1.285 1.277 -0.028
ENSG00000105298 E028 357.283903 0.0029251789 5.793897e-07 5.064767e-06 19 3623688 3624162 475 - 2.596 2.442 -0.513
ENSG00000105298 E029 139.298684 0.0113373622 3.023836e-05 1.797874e-04 19 3626596 3626815 220 - 2.246 2.006 -0.804